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Jonathan Kern, 32San Francisco, CA

Related to:
Sara De Guzman Heinz Kern Helga Kern 94

Jonathan Kern Phones & Addresses

San Francisco, CA   

New York, NY   

Philadelphia, PA   

512 Hampton Ln, Key Biscayne, FL 33149    305-9260998   

54 Riverside Dr APT 6C, New York, NY 10024    212-7245336   

Work

Company: Heschel, abraham joshua school inc Address: 20 W End Ave, New York, NY 10023 Phones: 212-5957087 Position: Secretary Industries: Elementary and Secondary Schools

Education

Degree: Graduate or professional degree
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Mentions for Jonathan Kern

Career records & work history

Medicine Doctors

Jonathan W. Kern

Specialties:
Diagnostic Radiology, Musculoskeletal Radiology
Work:
River Ranch Radiology
711 W 38 St STE B7, Austin, TX 78705
512-4549598 (phone) 512-4597449 (fax)
Education:
Medical School
University of Texas Southwestern Medical Center at Dallas
Graduated: 1987
Languages:
English, Spanish
Description:
Dr. Kern graduated from the University of Texas Southwestern Medical Center at Dallas in 1987. He works in Austin, TX and specializes in Diagnostic Radiology and Musculoskeletal Radiology.
Jonathan Kern Photo 1

Jonathan Walter Kern

Specialties:
Radiology
Diagnostic Radiology
Education:
The University of Texas Southwestern (1987)

Publications & IP owners

Us Patents

Method For Identifying Modulators Of The Nrf2-Keap1-Arep Pathway

US Patent:
2010002, Feb 4, 2010
Filed:
Nov 2, 2007
Appl. No.:
12/311644
Inventors:
Jonathan T. Kern - Souderton PA, US
John W. Hess - Lansdale PA, US
Geeta Kandpal - Blue Bell PA, US
Ian J. Reynolds - Collegeville PA, US
International Classification:
G01N 33/53
US Classification:
436501
Abstract:
A method for identifying modulators of the Keap1-NrG-ARE pathway is described. In particular, an assay is described that identifies molecules that inhibit the binding of a labeled Nrf2 peptide with the kelch domain of the Keap1 protein. Molecules that inhibit the binding are activators of the Keap 1-Nrf2-ARE pathway. Activation of the Keap 1-Nrf2-ARE pathway may result in an increased accumulation of Nrf2 and the subsequent induction of protective enzymes, for example, the phase 2 detoxification enzymes. Activators of the Keap1-NrG-ARE pathway are useful for combating oxidative stress-related disorders, such as those associated with cancer, emphysema, Huntington's disease, light-induced retinal damage, and stroke.

Leucine-Rich Repeat Kinase Enzyme Activity

US Patent:
2013029, Nov 7, 2013
Filed:
Oct 25, 2011
Appl. No.:
13/880992
Inventors:
John A. McCauley - Maple Glen PA, US
Hemaka A. Rajapakse - Wyncote PA, US
Thomas J. Greshock - Collegeville PA, US
John Sanders - Philadelphia PA, US
Boyoung Kim - Lansdale PA, US
Vanessa L. Rada - Hatfield PA, US
Jonathan T. Kern - Souderton PA, US
Heather H. Stevenson - Ardmore PA, US
Mark T. Bilodeau - Lansdale PA, US
International Classification:
C07D 495/04
C07D 495/10
US Classification:
5142338, 546114, 514301, 546 18, 514278, 544127
Abstract:
Disclosed are compounds of Formula (I): and the pharmaceutically acceptable salts thereof, wherein “A” is S—; —SO—, —SO—, —O— or NR—, wherein Rac is H, or Calkyl and Rthrough Rare defined herein. Also disclosed are pharmaceutical formulations comprising a compound of Formula I and methods of treating, managing, or ameliorating diseases amenable to treatment, management, or amelioration by inhibition of LRRK2 kinase activity, for example, Parkinson's disease.

Compounds Inhibiting Leucine-Rich Repeat Kinase Enzyme Activity

US Patent:
2013033, Dec 19, 2013
Filed:
Feb 23, 2012
Appl. No.:
14/000982
Inventors:
John A. McCauley - Maple Glen PA, US
Thomas J. Greshock - Collegeville PA, US
John Sanders - Collegeville PA, US
Heather H. Stevenson - Conshohocken PA, US
Jonathan T. Kern - Souderton PA, US
Ronald K. Chang - Oreland PA, US
International Classification:
C07D 409/14
C07D 417/14
C07F 7/10
C07D 409/04
US Classification:
514 63, 5483644, 514406, 548136, 514363, 548110, 5142102, 544371, 51425407, 544140, 5142335, 5462754, 514337, 546202, 514324
Abstract:
Disclosed are compounds of Formula I: and the pharmaceutically acceptable salts thereof, wherein “A” is S—; —SO—, —SO—, —O— or NR, and R, and Rthrough Rare defined herein. Also disclosed are pharmaceutical formulations comprising a compound of Formula I and methods of treating, managing, or ameliorating diseases amenable to treatment, management, or amelioration by inhibition of LRRK2 kinase activity, for example, Parkinson's disease.

Possible Relatives

Cynthia M Kern  David A Kern  Dawn Kern  Dean M Kern  Dale D Kern  Debbie A Kern  Deborah S Kern  Jonathan L Johnson  Jonathan A Stancil  Jonathan Standridge 

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