Inventors:
Josef Miller - Ann Arbor MI, US
Colleen LePrell - Ypsilanti MI, US
Jochen Schacht - Ann Arbor MI, US
Diane Prieskorn - Livonia MI, US
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 31/07
A61K 31/245
A61K 31/60
A61K 8/19
A61P 27/16
US Classification:
514725, 514458, 514474, 514733, 381 60
Abstract:
A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is equal to or greater than a sum of the effect of the individual components. The composition includes a biologically effective amount of at least one scavenger of singlet oxygen, a donor antioxidant, a third antioxidant, and a vasodilator. A method of treating hearing loss includes the step of internally administering the composition including a biologically effective amount of the at least one scavenger of singlet oxygen, the donor antioxidant, the third antioxidant, and the vasodilator to a mammal within three days of trauma to a middle or inner ear of the mammal.