Inventors:
Joshua Schwarz - Brooklyn NY
Assignee:
Lever Brothers Company - New York NY
International Classification:
C07C10322
Abstract:
A method of synthesizing and recovering with high yield and purity salicylamide compounds of the formula: ##STR1## wherein R. sub. 1 is a substituent having the formula --COC. sub. n H. sub. 2n+1 wherein n is an integer with a value of from 1 through to about 15, R. sub. 2 is a substituent selected from the group consisting of --H, --NO. sub. 2, --F, --Cl, --Br, --I, --CF. sub. 3, --CBr. sub. 3, --CCl. sub. 3, --CI. sub. 3 and R. sub. 1 and R. sub. 3 is an R. sub. 2 substituted heterocyclic compound selected (e. g. ) from the group consisting of furan, thiazole, benzothiazole and purine by: (a) reacting a phenyl salicylate ester bearing an R. sub. 1 substituent on the benzene ring of the salicylic acid portion thereof with an R. sub. 2 substituted aniline or a heterocyclic amine NH. sub. 2 -R. sub. 3, optionally in the presence of an inert solvent such as a halogenated or unhalogenated aromatic compound or a carbowax solvent, e. g.