Jun Feng, 547 Ayer Rd, Acton, MA 01720

2004015, Aug 5, 2004

Jan 31, 2003

10/356379

Jun Feng - Cambridge MA, US
Edward Hill - Portsmouth NH, US

G01S003/02

342/465000

A positioning system and method provide fast and accurate position of a portable signal transmitter. It is particularly suitable for tracking applications in a local area, e.g., virtual environment. This system includes at least two relay stations, at least one portable signal transmitter, and one central station. The portable signal transmitter emits a tracking signal, which is received by each of the relay stations and then relayed to the central station wirelessly or by a wired connection. Time data are measured either in the central station or in each of the relay stations. A data processor calculates the position coordinates of the portable signal transmitter. The position system can be used to track the location of one object within another object, such as a medical device within a human body.

2005017, Aug 11, 2005

Feb 3, 2005

11/050563

Sidney Young - Raleigh NC, US
Jun Feng - Carrboro NC, US
Ashish Sanil - Monmouth Junction NJ, US

G06F019/00

702027000

Pharmacophores in molecules may be identified by generating a set of conformations for a respective molecule. A respective conformation includes a series of features that are present or absent in the conformation, wherein a respective feature includes at least two molecular elements and at least one distance between the molecular elements. The features for a set of conformations for a given molecule are repeatedly compared to a model of feature importance of remaining molecules, to identify an inferred conformation of a given molecule, until the model of feature importance for the molecules converges.

2007029, Dec 20, 2007

Jun 10, 2007

11/811466

Jun Feng - Cambridge MA, US
Xueming Miao - Shanghai, CN

A61M 31/00

604 65

A portable infusion monitoring system displays the liquid level and flow rate data during infusion process, as well as gives an alarm for patents and nurses in hospital as the medical liquid in an IV bottle drops to a predetermined low level. This system comprises a set of liquid level sensor, a microprocessor, and a monitor terminal. The liquid level sensor generates an electric signal related to the liquid level inside the IV bottle. The microprocessor analyzes the electric parameters detected from the electric signal, and obtains the liquid level data. The liquid level data are sent to the monitor terminal for display, and an alarm is activated when the medical liquid inside the IV bottle drops to a predetermined low lever. Further functions of the monitor terminal includes an automatic switch to cut off the IV feeding process and send the alarm signal to a nurse station through signal network by wire or wirelessly. Several interference filtering methods are applied to increase signal/noise ratio, and therefore warrant the operation reliability.

2011016, Jul 7, 2011

Mar 11, 2011

12/932990

Jun Feng - Lincoln MA, US
Xueming Miao - Wuxi, CN

A61M 5/168

604 65, 604253

A portable infusion monitoring system detects the liquid level and flow rate during infusion process, as well as gives an alarm for patents and nurses in hospital as the medical liquid in an IV bottle drops to a predetermined low level. This system comprises a set of liquid level sensor, a microprocessor, and a monitor terminal. The liquid level sensor generates an electric signal related to the liquid level inside the IV bottle. The microprocessor statistically analyzes the electric parameters detected from the electric signal, and obtains the liquid level data including both the liquid level and liquid flow rate. The liquid level data are sent to the monitor terminal for display, and an alarm is activated when the medical liquid inside the IV bottle drops to a predetermined low lever. Further functions of the monitor terminal includes an automatic switch to cut off the IV feeding process and send the alarm signal to a nurse station through signal network by wire or wirelessly. Several interference filtering methods are applied to increase signal/noise ratio, and therefore warrant the operation reliability.

2011020, Aug 25, 2011

Feb 17, 2011

12/932128

Jun Feng - Lincoln MA, US
Xueming Miao - Wuxi, CN

G08B 21/00

340613

An IV infusion monitoring device is provided to measure and to display, during whole infusion process, the liquid level data including the weight of remaining medical liquid in an IV bottle, the liquid flow rate and the remaining time from the completion of an IV infusion process. It also gives alarm as the medical liquid in an IV bottle drops to a predetermined low level. The IV infusion monitoring system comprises an electric load sensor, a signal processor, a monitor terminal and a power provided preferably by a battery. The load sensor measures the weight of the medical liquid in the IV bottle. The measured signal is then transmitted to the signal processor for processing and generating the liquid level data, which are then sent to the monitor terminal for display. The monitor terminal can also generate an alarm if the liquid level drops to the predetermined value. Furthermore, the monitoring device combines with a server and a plurality of PDA devices to form a communication network so that a nurse can monitor the IV infusion process from a remote location.

2014000, Jan 2, 2014

Jun 14, 2013

13/918048

Michael P. Clark - Concord MA, US
Upul K. Bandarage - Lexington MA, US
Ioana Davies - Watertown MA, US
John P. Duffy - Northborough MA, US
Huai Gao - Arlington MA, US
Jun Feng - Acton MA, US
Jianglin Liang - Needham MA, US
Joseph M. Kennedy - Charlestown MA, US
Mark W. Ledeboer - Acton MA, US
Brian Ledford - Norton MA, US
Francois Maltais - Tewksbury MA, US
Emanuele Perola - Brookline MA, US

Vertex Pharmaceuticals Incorporated - Cambridge MA

C07D 471/04
A61K 31/506
A61K 45/06
A61K 31/5377

5142342, 544122, 544328, 514275, 544230, 435238

Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I):or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

5374936, Dec 20, 1994

Feb 28, 1994

8/202504

Jun Feng - Cambridge MA

G01S 302

342457

A security system provides accurate positioning, in a two or three dimensional coordinate system, of an alarm signal transmitter which emits an alarm signal upon activation by a user. The security system includes at least three relay stations, at least one portable signal transmitter, and a central station. The alarm signal from the signal transmitter is received by the relay stations at different time intervals or with different intensities. The time or intensity data are then sent to the central station for processing, wherein the coordinates of the signal transmitter are quickly determined by solving a set of equations based on these data. The accuracy of the coordinates of the signal transmitter depends on accuracy of the measured time or intensity data.

2023006, Mar 2, 2023

Jul 29, 2021

17/388100

- WALTHAM MA, US
BRIAN LUCAS - ARLINGTON MA, US
TIANSHENG WANG - CONCORD MA, US
JUN FENG - ACTON MA, US

C07D 451/14
C07D 451/06
C07D 498/08
C07D 519/00

Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.