Resumes & CV records
Resumes
Klaus Peter Radtke, 662416 Maxton Crest Dr, Apex, NC 27502
Klaus Radtke Phones & Addresses
2416 Maxton Crest Dr, Apex, NC 27502 919-6619296
Spring Valley, CA
Cary, NC
Raleigh, NC
2416 Maxton Crest Dr, Apex, NC 27539 919-6375975
Social networks
Klaus Peter Radtke
Linkedin
Work
Position:
Protective Service Occupations
Education
Degree:
Associate degree or higher
Emails
Mentions for Klaus Peter Radtke
Publications & IP owners
Us Patents
Elisa To Detect Multimeric Forms Of A Protein
US Patent:
2007007, Apr 5, 2007
Filed:
Jul 11, 2006
Appl. No.:
11/485043
Inventors:
Mary Heeb - San Diego CA, US
Klaus Radtke - Apex NC, US
Klaus Radtke - Apex NC, US
International Classification:
G01N 33/53
US Classification:
435007500, 435007920
Abstract:
The present invention provides methods of detecting multimeric forms of protein S, or other proteins in plasma, complex mixtures, and tissue samples. The invention further provides methods of diagnosing a subject as having or as being at risk for having a multimeric protein-associated disease. The invention further provides methods of monitoring a therapeutic regimen for treating a subject having a multimeric protein-associated disease.
Methods For Extracting Proteins From A Blood-Based Material
US Patent:
2022040, Dec 22, 2022
Filed:
Aug 24, 2022
Appl. No.:
17/894593
Inventors:
- Charleston SC, US
Dennis Curtin - New York NY, US
Klaus Peter Radtke - Apex NC, US
Dennis Curtin - New York NY, US
Klaus Peter Radtke - Apex NC, US
International Classification:
C07K 1/36
C07K 1/22
C07K 1/34
C07K 1/16
C07K 14/81
C07K 16/06
C07K 1/30
A61K 38/48
A61K 38/36
A61K 35/14
A61K 38/38
A61K 38/37
A61K 38/57
B01D 15/36
B01D 15/38
B01D 61/02
B01D 61/14
C07K 1/22
C07K 1/34
C07K 1/16
C07K 14/81
C07K 16/06
C07K 1/30
A61K 38/48
A61K 38/36
A61K 35/14
A61K 38/38
A61K 38/37
A61K 38/57
B01D 15/36
B01D 15/38
B01D 61/02
B01D 61/14
Abstract:
Methods of producing multiple protein products from blood-based materials including alpha-1-proteinase inhibitor, gamma globulin, albumin, and other proteins are described herein. The inventive methods include steps of fractionation that utilize a combination of salt and organic solvent. Advantageously, the inventive methods are simple and produce alpha-1-proteinase inhibitor, gamma globulin, albumin, and other proteins in high yields. The sequence of process steps can be selected to obtain multiple products from various in-process materials, such as supernatants, pastes, chromatography flow-though, and chromatography washes.
Systems And Methods For Process Scale Isolation Of Immunoglobulin G
US Patent:
2022020, Jun 30, 2022
Filed:
Dec 22, 2021
Appl. No.:
17/560163
Inventors:
- Charleston SC, US
Dennis Curtin - Charleston SC, US
Klaus Peter Radtke - Apex NC, US
Ryan Dorfman - Essex VT, US
Matthew Whelihan - Colchester VT, US
Dennis Curtin - Charleston SC, US
Klaus Peter Radtke - Apex NC, US
Ryan Dorfman - Essex VT, US
Matthew Whelihan - Colchester VT, US
International Classification:
C07K 1/30
C07K 1/22
C07K 1/36
C07K 16/06
C07K 1/22
C07K 1/36
C07K 16/06
Abstract:
Methods are provided for isolation of immunoglobulin G (IgG) from plasma, where IgG is initially fractioned by salt precipitation, followed by successive ion exchange steps in which IgG appears in unbound, flow-through fractions of the ion exchange steps. Some embodiments employ successive anion exchange steps. Other embodiments employ an anion exchange step followed by application of flow-through of the anion exchange step to a cation exchange step, with IgG collected in flow-through fractions from the cation exchange step. IgG is collected at high yield (typically about 75% or greater) and high purity. Avoidance of binding and elution from chromatography media simplifies processing and scale up without sacrificing IgG quality or yield.
Compositions And Methods For Isolating Proteins
US Patent:
2023012, Apr 27, 2023
Filed:
Dec 22, 2021
Appl. No.:
17/560219
Inventors:
- Charleston SC, US
Dennis Curtin - Charleston SC, US
Klaus Peter Radtke - Apex NC, US
Ryan Dorfman - Essex VT, US
Matthew Whelihan - Colchester VT, US
Dennis Curtin - Charleston SC, US
Klaus Peter Radtke - Apex NC, US
Ryan Dorfman - Essex VT, US
Matthew Whelihan - Colchester VT, US
International Classification:
C07K 1/22
C07K 1/20
C07K 1/18
C07K 1/16
B01D 15/36
C07K 1/20
C07K 1/18
C07K 1/16
B01D 15/36
Abstract:
Systems and methods are described in which proteins are isolated from complex solution using successive chromatographic separations that retain the protein of interest in the flow-through. At least one of the chromatography media used is selected to be capable of interacting with both contaminants and the protein of interest, however capacity of this media is selected such that the protein of interest is displaced and remains in the flow-through.
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