Laura G Lewis, 40Burke, VA

2014006, Mar 6, 2014

Feb 3, 2012

13/983270

Shashi K. Murthy - Newton MA, US
Laura H. Lewis - Boston MA, US
Brian D. Plouffe - Smithfield RI, US

NORTHEASTERN UNIVERSITY - Boston MA

B03C 1/015
H05K 3/10
C12N 13/00

4351739, 422527, 29850

Disclosed herein are devices for the magnetophoretic separation of target biological materials including a separation chamber that has a plurality of channels, and one or more wires carrying a current, the wires generating a magnetic force that deflects magnetically-labeled target biological materials into a buffer stream. In addition, methods of separating target biological materials from non-target biological materials in a sample are disclosed. Finally, methods for constructing a magnetophoretic separation device are disclosed.

2020017, Jun 4, 2020

Jul 22, 2019

16/518708

- Boston MA, US
Emery N. Brown - Boston MA, US
Laura D. Lewis - Cambridge MA, US
Brandon M. Westover - Belmont MA, US
ShiNung Ching - Cambridge MA, US

A61B 5/00
A61B 5/0478

Systems and methods are provided for monitoring a subject, and particularly, for inferring an underlying brain state present in absence of current conditions. In some aspects, a method for monitoring the subject is provided including steps of receiving physiological feedback from at least one sensor configured to acquire physiological information from locations associated with a subject's brain, assembling a set of time-series data using the received physiological feedback, and identifying portions of the set of time-series data that indicate a burst suppression state. The method also includes identifying a burst characteristic profile associated with a burst pattern determined from the identified portions, and comparing the burst characteristic against a reference set of burst profiles. The method further includes determining, based on the comparison, a likelihood of a brain state of the subject underlying the burst suppression state, and generating a report indicative of the likelihood of the determined brain state.

2015001, Jan 8, 2015

Jun 27, 2014

14/318277

Patrick L. Purdon - Somerville MA, US
Emery N. Brown - Boston MA, US
Laura D. Lewis - Cambridge MA, US
Brandon M. Westover - Belmont MA, US
ShiNung Ching - Cambridge MA, US

A61B 5/0476
A61B 5/00

600544

Systems and methods are provided for monitoring a subject, and particularly, for inferring an underlying brain state present in absence of current conditions. In some aspects, a method for monitoring the subject is provided including steps of receiving physiological feedback from at least one sensor configured to acquire physiological information from locations associated with a subject's brain, assembling a set of time-series data using the received physiological feedback, and identifying portions of the set of time-series data that indicate a burst suppression state. The method also includes identifying a burst characteristic profile associated with a burst pattern determined from the identified portions, and comparing the burst characteristic against a reference set of burst profiles. The method further includes determining, based on the comparison, a likelihood of a brain state of the subject underlying the burst suppression state, and generating a report indicative of the likelihood of the determined brain state.

2014031, Oct 23, 2014

Apr 23, 2014

14/260006

Patrick L. Purdon - Somerville MA, US
Laura D. Lewis - Cambridge MA, US
Oluwaseun Akeju - Dorchester MA, US
Emery N. Brown - Brookline MA, US

A61B 5/00
A61B 5/145
A61B 5/0476

600301, 600300

A system and method for monitoring and controlling the administration of at least one drug having anesthetic properties are provided. In certain embodiments, the method includes assembling physiological data, obtained from a plurality of sensors placed on a subject, into sets of time-series data, separating, from the sets of time-series data, a plurality of low frequency signals, and determining, from the plurality of low frequency signals, at least one of coherence information and synchrony information. The method can also include identifying, using the at least one of the coherence information and the synchrony information, spatiotemporal signatures indicative of at least one of a current state and a predicted future state of the patient consistent with the administration of at least one drug having anesthetic properties and generating a report indicating at least one of the current state and the predicted future state of the patient induced by the drug.

2014021, Jul 31, 2014

Jul 16, 2012

14/232830

Laura H. Lewis - Boston MA, US
Jeffrey E. Shield - Lincoln NE, US
Katayun Barmak - White Plains NY, US

H01F 1/01
H01F 41/02

335302, 419 62, 148101

The invention provides rare earth-free permanent magnetic materials and methods of making them. The materials can be used to produce magnetic structures for use in a wide variety of commercial applications, such as motors, generators, and other electromechanical and electronic devices. Magnets fabricated using the materials can be substituted for magnets requiring rare earth elements that are costly and in limited supply. The invention provides two different types of magnetic materials. The first type is based on an iron-nickel alloy that is doped with one or more doping elements to promote the formation of L1crystal structure. The second type is a nanocomposite particle containing magnetically hard and soft phases that interact to form an exchange spring magnetic material. The hard phase contains Fe or FeCo, and the soft phase contains AlMnC.