Inventors:
George Doherty - Superior NJ, US
Michael Forrest - Shrewsbury NJ, US
Richard Hajdu - Old Bridge NJ, US
Jeffrey Hale - Westfield NJ, US
Li Zhen - Scotch Plains NJ, US
Susanne Mandala - Scotch Plains NJ, US
Sander Mills - Scotch Plains NJ, US
Hugh Rosen - Springfield NJ, US
Edward Scolnick - Wynnewood PA, US
International Classification:
A61K031/66
Abstract:
The present invention encompasses a method of treating an immunoregulatory abnormality in a mammalian patient in need of such treatment comprising administering to said patient a compound which is an agonist of the S1P1/Edg1 receptor in an amount effective for treating said immunoregulatory abnormality, wherein said compound possesses a selectivity for the S1P1/Edg1 receptor over the S1PR3/Edg3 receptor, said compound administered in an amount effective for treating said immunoregulatory abnormality. Pharmaceutical compositions are included. The invention also encompasses a method of identifying candidate compounds that are agonists of the S1P1/Edg1 receptor and which possesses a selectivity for the S1P1/Edg1 receptor over the S1PR3/Edg3 receptor. The invention further encompasses a method of treating a respiratory disease or condition in a mammalian patient in need of such treatment comprising administering to said patient a compound which is an agonist of the S1P1/Edg1 receptor in an amount effective for treating said respiratory disease or condition, wherein said compound possesses a selectivity for the S1P1/Edg1 receptor over the S1PR3/Edg3 receptor.
