Lili L Wang, 6772 Kingsbury St, Wellesley, MA 02481

2018014, May 31, 2018

Sep 28, 2017

15/718987

- New Brunswick NJ, US
- Cambridge MA, US
Lin Chen - Piscataway NJ, US
Timothy Lewis - Marlborough MA, US
Ben Munoz - Netwonville MA, US
Lili Wang - Chestnut Hill MA, US

C07D 209/48
A61K 31/472
C07D 207/452
C07D 405/12
C07D 401/06
A61K 31/4725
C07D 401/14
G01N 33/50
C07D 217/16
C07D 335/06

A method of identifying compounds as direct inhibitors of Keap1-Nrf2 interaction through high-throughput screening and lead development. The direct inhibitors of Keap1-Nrf2 interaction are more specific and free of various undesirable effects than existing indirect inhibitors, and are potential drug candidates of chemopreventive and therapeutic agents for treatment of various diseases or conditions involving oxidative stress and/or inflammation, including but not limited to cancers, diabetes, Alzheimer's, and Parkinson's. Novel compounds are identified and methods of preventing or treating diseases or conditions related to Keap1-Nrf2 interaction activity by use of the novel compounds identified or compositions containing such compounds are also disclosed.

2015015, Jun 4, 2015

Feb 11, 2015

14/619935

- Sunnyvale CA, US
Zhaohui ZHANG - Westford MA, US
Lili WANG - Chelmsford MA, US

H04L 12/721
H04L 12/751

A network device identifies an Open Shortest Path First (OSPF) link between the network device and a layer 2 network as one of a point-to-multipoint over broadcast interface or a point-to-multipoint over non-broadcast multi access (NBMA) interface, and performs database synchronization and neighbor discovery and maintenance using one of a broadcast model or a NBMA model. The network device also generates a link-state advertisement for the network device, where the link-state advertisement includes a separate link description for each point-to-point link within the layer 2 network; and sends the link-state advertisement to each fully adjacent neighbor in the layer 2 network.

2015009, Apr 2, 2015

Sep 30, 2013

14/042644

- Sunnyvale CA, US
Lili Wang - Chelmsford MA, US

Juniper Networks, Inc. - Sunnyvale CA

H04L 12/721

370254

Techniques are described for utilizing two-part metrics with link state routing protocols of computer networks. For example, link state advertisements communicated by a router convey outbound cost metrics representative of outbound costs for the router to send network traffic to a network, and inbound cost metrics representative of inbound costs to receive network traffic from the network. The techniques may be particularly useful with respect to shared access networks, including broadcast or non-broadcast multi-access networks.

2014025, Sep 11, 2014

Oct 31, 2012

14/355419

- New Brunswick NJ, US
- Cambridge MA, US
Lin Chen - Piscataway NJ, US
Timothy Lewis - Marlborough MA, US
Ben Munoz - Netwonville MA, US
Lili Wang - Chestnut Hill MA, US

THE BROAD INSTITUTE, INC. - Cambridge MA
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY - New Brunswick NJ

C07D 401/14
G01N 33/50
C07D 209/48
C07D 401/06
C07D 217/16

514296, 514307, 546146, 546 99, 514323, 546201, 514417, 548473, 506 10

A method of identifying compounds as direct inhibitors of Keap1-Nrf2 interaction through high-throughput screening and lead development. The direct inhibitors of Keap1-Nrf2 interaction are more specific and free of various undesirable effects than existing indirect inhibitors, and are potential drug candidates of chemopreventive and therapeutic agents for treatment of various diseases or conditions involving oxidative stress and/or inflammation, including but not limited to cancers, diabetes, Alzheimer's, and Parkinson's. Novel compounds are identified and methods of preventing or treating diseases or conditions related to Keap1-Nrf2 interaction activity by use of the novel compounds identified or compositions containing such compounds are also disclosed.