John McenteeLivermore, CA

6649348, Nov 18, 2003

Jun 29, 2001

09/896572

Jay K. Bass - Mountain View CA
John F. McEntee - Boulder Creek CA
Tim J. Lazaruk - Redwood City CA

Agilent Technologies Inc. - Palo Alto CA

C12Q 168

435 6, 435 71, 435174, 4352831, 4352872, 4352885, 536 231, 536 243, 536 253, 536 2531, 530333, 530334, 530335

Apparatus and methods are disclosed for synthesizing a plurality of compounds on the surface of supports. Biopolymer features are attached to the surfaces of the supports. The synthesis generally comprises a plurality of steps. In the present invention at least two of the steps are performed by placing a support having a functionalized surface into a chamber of a flow cell and subjecting the surface to a step of the synthesis and placing the support into a chamber of another flow cell and subjecting the surface to another step of the synthesis. An apparatus generally comprises a plurality of flow cells and one or more fluid dispensing stations are mounted on the platform and are in fluid communication with one or more of the plurality of flow cells. A station for monomer addition to the surface of the support is mounted on the platform. The apparatus further comprises a mechanism for moving a support to and from the station for monomer addition and a flow cell and from one flow cell to another flow cell.

6713023, Mar 30, 2004

Jun 29, 2001

09/896596

Jay K. Bass - Mountain View CA
John F. McEntee - Boulder Creek CA
Tim J. Lazaruk - Redwood City CA

Agilent Technologies, Inc. - Palo Alto CA

B01L 300

422102, 422 50, 422 58, 422 681, 422 81, 422 82, 422100, 422103, 422104, 436 43

Devices and methods are disclosed for synthesizing compounds on the surface of supports. The devices are flow devices, which include a housing comprising a housing chamber. The housing has an opening adapted for insertion of a support into the housing chamber. A sealing member is movably mounted in the housing chamber and adapted to engage the support to form a reagent chamber between a surface of the support and a surface of the sealing member. A mechanism is included for moving the sealing member within the housing chamber. The device has both an inlet and an outlet, which are both in fluid communication with the reagent chamber. In the methods of the invention a support is placed into a chamber of a device such as described above. The mechanism adapted to engage the support on a surface opposite the surface engaged by the sealing member is activated to urge the support toward the sealing member. The pressure-activated mechanism is activated to urge the support against the aforesaid mechanism and against an interior wall of the housing chamber to form the reagent chamber.

6790620, Sep 14, 2004

Dec 24, 2001

10/035787

Jay K. Bass - Mountain View CA
John F. McEntee - Boulder Creek CA
Tim J. Lazaruk - Redwood City CA
Brent T. Tolosko - Santa Clara CA

Agilent Technologies, Inc. - Palo Alto CA

C12Q 168

435 6, 435 71, 435174, 4352831, 4352885, 422 50, 422129, 422134, 536 231, 536 253

Apparatus and methods are disclosed for forming a reaction chamber having relatively small volumes. An apparatus comprises two elements and a mechanism for introducing a gas to form a movable aerodynamic seal between the elements. In this manner a chamber having a controllable interior environment is formed. One of the elements may have at least a portion of a device for dispensing reagents sealingly affixed therein. The other element may be adapted for introduction of a support into the interior of the chamber formed by the top and the bottom element. The apparatus may be used in methods for synthesizing biopolymers on a support.

6919531, Jul 19, 2005

Mar 25, 2002

10/106132

Alexander S. Williamson - Palo Alto CA, US
John F. McEntee - Boulder Creek CA, US

Agilent Technologies, Inc. - Palo Alto CA

B23K026/00

21912169, 21912185

Methods for producing glass substrates having scribed edges with straight and smooth ends substantially free of edge protrusions, and microarray glass substrates produced thereby, are provided. In certain embodiments, at least one scribe line is scribed in glass using reduced laser power at the beginning and end of each scribe line relative to the laser power used to scribe the remaining portions of each respective scribe line. In other embodiments, a heat absorbing laser element is positioned adjacent the beginning and end of each scribe line. In all embodiments, the scribed glass is singulated to produce a plurality of scribed glass pieces, each having straight and smooth ends substantially free of edge protrusions. The scribed glass can be used as substrates for biopolymeric microarrays. Also provided are biopolymeric microarrays produced from the subject methods and kits which include the subject microarrays, as well as methods for using the same.

7026573, Apr 11, 2006

Feb 28, 2005

11/069833

Alexander S. Williamson - Palo Alto CA, US
John F. McEntee - Boulder Creek CA, US

Agilent Technologies, Inc. - Palo Alto CA

B23K 26/00

21912172, 21912167, 21912185

Methods for producing glass substrates having scribed edges with straight and smooth ends substantially free of edge protrusions, and microarray glass substrates produced thereby, are provided. In certain embodiments, at least one scribe line is scribed in glass using reduced laser power at the beginning and end of each scribe line relative to the laser power used to scribe the remaining portions of each respective scribe line. In other embodiments, a heat absorbing laser element is positioned adjacent the beginning and end of each scribe line. In all embodiments, the scribed glass is singulated to produce a plurality of scribed glass pieces, each having straight and smooth ends substantially free of edge protrusions. The scribed glass can be used as substrates for biopolymeric microarrays. Also provided are biopolymeric microarrays produced from the subject methods and kits which include the subject microarrays, as well as methods for using the same.

7160172, Jan 9, 2007

Dec 16, 2005

11/303763

David Frost - San Jose CA, US
John McEntee - Boulder Creek CA, US
Adam Sean Harbison - Los Gatos CA, US

Xyratex Technology Ltd. - Havant Hampshire

B24B 21/12

451 5, 451336, 451 41, 15 77, 15 883, 198733

Multi-disk processing system and method of continuous finishing of memory media disks for digital data storage systems in preparation for magnetic memory coating, comprising four main sub-systems: 1) multiple driven spindles mounted on a chassis, at 3, 6, 9 and 12 o'clock positions; 2) finishing tape head units mounted on a base; 3) a robotic handler for loading and unloading disks onto/off at least one of the spindles; and 4) a programmable system controller that controls the sub-system operations and loading/unloading. The tape head sub-system includes its own programmable controller and sensors for control of the finishing tape advance. The multiple spindles and handler rotate relative to each other. In a preferred embodiment, the spindles are mounted on a rotating turntable that also oscillates. Alternately, the spindles are fixed in position and a rotating handler with multiple grippers for simultaneously loading/unloading disks from all spindles at once is used.

7166258, Jan 23, 2007

Nov 4, 2002

10/287338

Jay K. Bass - Mountain View CA, US
John F. McEntee - Boulder Creek CA, US

Agilent Technologies, Inc. - Santa Clara CA

B01L 3/00

422102, 422104

A method and system for economically packaging microarrays into sealed reaction chambers and storage vessels. A pocket strip is manufactured as a linear sequence of pockets, or wells, into which microarrays are positioned. A cover strip is then heat sealed to the upper surface of the pocket strip to create a linear sequence of sealed reaction chambers or storage vessels, each containing a microarray. Mechanical features or optical features are included along the length of the pocket strip to facilitate mechanical translation and positioning of microarrays embedded within the microarray strip. Septa are affixed to, or embedded within, the cover strip to provide resealable ports through which solutions can be introduced into, or extracted from, the reaction chambers. In an alternate embodiment, the microarrays are deposited directly onto the cover strip, eliminating the need for separate microarray substrates.

2002016, Oct 31, 2002

Apr 30, 2001

09/846058

Jay Bass - Mountain View CA, US
John McEntee - Boulder Creek CA, US
Tim Lazaruk - Redwood City CA, US
Brent Tolosko - Santa Clara CA, US

C12Q001/68
B05D003/00
G01N033/53
G01N033/542
C12M001/34

435/006000, 435/007900, 435/287200, 427/002110

A method of fabricating an array of multiple features of different chemical moieties on a substrate surface, and a method of using arrays so fabricated. The fabrication method includes determining an identity of a first direction across the substrate surface (such as a drawn direction) along which the substrate surface has a higher height uniformity than along a second direction across the substrate. Chemical moieties are placed on the substrate so as to provide features thereon along rows more closely aligned with the first direction than the second direction.