Lin S Tang, 602491 Eucalyptus Way, San Bruno, CA 94066

2020008, Mar 12, 2020

Nov 19, 2019

16/689018

- George Town, KY
Shengrong LIN - Fremont CA, US
Lin Fung TANG - San Francisco CA, US

C12Q 1/6865
C12Q 1/6806
C12Q 1/6874
C12Q 1/6853

In some aspects, the present disclosure provides methods for enriching amplicons, or amplification products, comprising a concatemer of at least two or more copies of a target polynucleotide. In some embodiments, a method comprises sequencing the amplicons comprising at least two or more copies of a target polynucleotide. In some embodiments, the target polynucleotides comprise sequences resulting from chromosome rearrangement, including but not limited to point mutations, single nucleotide polymorphisms, insertions, deletions, and translocations including fusion genes. In some aspects, the present disclosure provides compositions and reaction mixtures useful in the described methods.

2020001, Jan 9, 2020

Jun 7, 2019

16/434941

- George Town KY, US
Shengrong LIN - Fremont CA, US
Lin Fung TANG - San Francisco CA, US

C12Q 1/6865
C12Q 1/6853
C12Q 1/6806
C12Q 1/6874

In some aspects, the present disclosure provides methods for enriching amplicons, or amplification products, comprising a concatemer of at least two or more copies of a target polynucleotide. In some embodiments, a method comprises sequencing the amplicons comprising at least two or more copies of a target polynucleotide. In some embodiments, the target polynucleotides comprise sequences resulting from chromosome rearrangement, including but not limited to point mutations, single nucleotide polymorphisms, insertions, deletions, and translocations including fusion genes. In some aspects, the present disclosure provides compositions and reaction mixtures useful in the described methods.