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Lino G Silva, 80165 S Union St, Lawrence, MA 01843

Known as:
Leno G Silva

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Lawrence, MA   

Rocky Hill, CT   

Riverside, RI   

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Lino Orlando Montalvo Silva

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Us Patents

Biodegradable Elastomers

US Patent:
2009001, Jan 8, 2009
Filed:
Mar 5, 2007
Appl. No.:
11/682139
Inventors:
Christopher J. Bettinger - Boston MA, US
Joost P. Bruggeman - Boston MA, US
Lino Da Silva Ferreira - Cambridge MA, US
Jeffrey M. Karp - Brookline MA, US
Robert S. Langer - Newton MA, US
Christiaan Nijst - Eindhoven, NL
Andreas Zumbuehl - Bern, CH
Jason Burdick - Philadelphia PA, US
Sonia J. Kim - West Nyack NY, US
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
International Classification:
C12N 11/08
US Classification:
435180
Abstract:
The present inventions in various aspects provide elastic polymers compositions for encapsulation of cells. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked in the presence of glycerol and a population of cells to form elastic porous polymer scaffolds suitable for cell encapsulation and/or proliferation.

Biodegradable Elastomers

US Patent:
2009004, Feb 19, 2009
Filed:
Jan 12, 2007
Appl. No.:
11/623041
Inventors:
Christopher J. Bettinger - Boston MA, US
Joost P. Bruggeman - Boston MA, US
Lino Da Silva Ferreira - Cambridge MA, US
Jeffrey M. Karp - Brookline MA, US
Robert S. Langer - Newton MA, US
Christiaan Nijst - Eindhoven, NL
Andreas Zumbuehl - Bern, CH
Jason Burdick - Philadelphia PA, US
Sonia J. Kim - West Nyack NY, US
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
International Classification:
A61K 35/12
C08G 63/00
C08G 63/06
C08G 63/66
C08G 73/02
A61K 47/34
A61N 1/30
A61K 31/7088
A61K 31/715
A61K 38/02
A61K 35/00
US Classification:
424 937, 528271, 527311, 528361, 528313, 521182, 5147723, 514 44, 514 54, 514 2, 424520, 604 21
Abstract:
The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.

Formation Of Vascular Networks Using Embryonic Stem Cells

US Patent:
2010023, Sep 16, 2010
Filed:
May 25, 2007
Appl. No.:
12/300419
Inventors:
Lino da Silva Ferreira - Cambridge MA, US
Robert S. Langer - Newton MA, US
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
International Classification:
A61K 35/54
C12N 5/0735
C12N 5/07
US Classification:
424 937, 435366
Abstract:
In various aspects, provided are methods for providing CD34 cells from embryoid bodies and stimulating these cells to give rise to endothelial-like and/or smooth muscle-like cells. In various embodiments are provided methods that produce endothelial-like and/or smooth muscle-like cells that have functionality and/or preserved genetic integrity. In various aspects, provided are tissue engineering constructs comprising endothelial-like and/or smooth muscle-like cells produced according to a method the present inventions.

Method Comprising Contacting Tissue With A Cross-Linkable Polyester Prepolymer

US Patent:
2021012, May 6, 2021
Filed:
Nov 13, 2020
Appl. No.:
17/097901
Inventors:
- Cambridge MA, US
Joost P. Bruggeman - Schorl, NL
Lino da Silva Ferreira - Cambridge MA, US
Jeffrey M. Karp - Chestnut Hill MA, US
Robert S. Langer - Newton MA, US
Christiaan Nijst - Amsterdam, NL
Andreas Zumbuehl - Nyon, CH
Jason Burdick - Philadelphia PA, US
Sonia J. Kim - West Nyack NY, US
International Classification:
A61L 31/06
A61L 27/18
A61L 27/38
A61L 27/58
C08G 63/685
C08J 3/24
C08K 5/00
C12N 11/08
A61K 35/12
A61K 35/48
A61K 45/06
A61L 31/14
Abstract:
The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.

Possible Relatives

Cynthia L Silva  David M Silva  Dawn S Silva  Dayanara Silva  Daisy Silva  Debbie Silva  Deborah K Silva  Lino E Maldonado  Lino R Miranda  Lino G Mora 

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