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Lisa R Timmons, 52Navy Sup Dpt, PA

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Mechanicsburg, PA   

New Oxford, PA   

Hanover, PA   

Sykesville, MD   

Westminster, MD   

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Lisa Timmons

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Lisa Timmons

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Lisa Timmons

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Lisa Timmons

Location:
United States

Publications & IP owners

Us Patents

Genetic Inhibition By Double-Stranded Rna

US Patent:
7538095, May 26, 2009
Filed:
Oct 30, 2002
Appl. No.:
10/282996
Inventors:
Andrew Fire - Baltimore MD, US
Stephen Kostas - Chicago IL, US
Mary Montgomery - St. Paul MN, US
Lisa Timmons - Lawrence KS, US
SiQun Xu - Ballwin MO, US
Hiroaki Tabara - Shizuoka, JP
Samuel E. Driver - Providence RI, US
Craig C. Mello - Shrewsbury MA, US
Assignee:
The Carnegie Institution of Washington - Washington DC
The University of Massachusetts - Boston MA
International Classification:
A61K 31/70
C07H 21/04
C12N 5/00
C12N 15/00
C12Q 1/68
C12P 19/34
US Classification:
514 44, 536 245, 435 6, 435 913, 4353201, 435325
Abstract:
A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.

Genetic Inhibition By Double-Stranded Rna

US Patent:
7560438, Jul 14, 2009
Filed:
Oct 30, 2002
Appl. No.:
10/283190
Inventors:
Andrew Fire - Baltimore MD, US
Stephen Kostas - Chicago IL, US
Mary Montgomery - St. Paul MN, US
Lisa Timmons - Lawrence KS, US
SiQun Xu - Ballwin MO, US
Hiroaki Tabara - Shizuoka, JP
Samuel E. Driver - Providence RI, US
Craig C. Mello - Shrewsbury MA, US
Assignee:
The Carnegie Institution of Washington - Washington DC
The University of Massachusetts - Boston MA
International Classification:
A61K 31/70
C07H 21/04
C12N 5/00
C12N 15/00
C12Q 1/68
C12P 19/34
US Classification:
514 44, 536 235, 435 6, 435 913, 4353201, 435325
Abstract:
A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.

Genetic Inhibition By Double-Stranded Rna

US Patent:
7622633, Nov 24, 2009
Filed:
Oct 30, 2002
Appl. No.:
10/283267
Inventors:
Andrew Fire - Baltimore MD, US
Stephen Kostas - Chicago IL, US
Mary Montgomery - St. Paul MN, US
Lisa Timmons - Lawrence KS, US
SiQun Xu - Ballwin MO, US
Hiroaki Tabara - Shizuoka, JP
Samuel E. Driver - Providence RI, US
Craig C. Mello - Shrewsbury MA, US
Assignee:
Carnegie Institution of Washington - Washington DC
International Classification:
C12N 15/82
C12N 15/90
C12N 5/10
US Classification:
800285, 435468
Abstract:
A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.

Genetic Inhibition By Double-Stranded Rna

US Patent:
2008005, Feb 28, 2008
Filed:
Jul 13, 2007
Appl. No.:
11/826385
Inventors:
Andrew Fire - Baltimore MD, US
Stephen Kostas - Chicago IL, US
Mary Montgomery - St. Paul MN, US
Lisa Timmons - Lawrence KS, US
SiQun Xu - Ballwin MO, US
Hiroaki Tabara - Shizuoka, JP
Samuel Driver - Providence RI, US
Craig Mello - Shrewsbury MA, US
International Classification:
A61K 31/7105
A01H 5/00
A61K 48/00
C12N 1/00
A61P 43/00
A01K 67/00
US Classification:
424093200, 435243000, 514044000, 800013000, 800295000
Abstract:
A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.

Genetic Inhibition By Double-Stranded Rna

US Patent:
2013002, Jan 31, 2013
Filed:
Jul 25, 2012
Appl. No.:
13/557995
Inventors:
Andrew Fire - Baltimore MD, US
Stephen Kostas - Chicago IL, US
Mary Montgomery - St. Paul MN, US
Lisa Timmons - Lawrence KS, US
SiQun Xu - Ballwin MO, US
Hiroaki Tabara - Mishima, JP
Samuel E. Driver - Providence RI, US
Craig C. Mello - Shrewsbury MA, US
International Classification:
C12N 15/82
US Classification:
435468, 4353201
Abstract:
A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.

Genetic Inhibition By Double-Stranded Rna

US Patent:
6506559, Jan 14, 2003
Filed:
Dec 18, 1998
Appl. No.:
09/215257
Inventors:
Andrew Fire - Baltimore MD
Stephen Kostas - Chicago IL
Mary Montgomery - St. Paul MN
Lisa Timmons - Lawrence KS
SiQun Xu - Ballwin MO
Hiroaki Tabara - Shizuoka, JP
Samuel E. Driver - Providence RI
Craig C. Mello - Shrewsbury MA
Assignee:
Carnegie Institute of Washington - Washington DC
International Classification:
C12Q 168
US Classification:
435 6, 435 911, 435325
Abstract:
A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.

Genetic Inhibition By Double-Stranded Rna

US Patent:
2014035, Nov 27, 2014
Filed:
Aug 8, 2014
Appl. No.:
14/454775
Inventors:
- Washington DC, US
Stephen Kostas - Towson MD, US
Mary Montgomery - St. Paul MN, US
Lisa Timmons - Lawrence KS, US
SiQun Xu - Ballwin MO, US
Hiroaki Tabara - Mishima, JP
Samuel E. Driver - Providence RI, US
Craig C. Mello - Shrewsbury MA, US
Assignee:
UNIVERSITY OF MASSACHUSETTS - Boston MA
International Classification:
C12N 15/113
US Classification:
514 44 A, 435375
Abstract:
A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.

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