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Man Kwok Zhu, 431245 Chipman Ln, North Liberty, IA 52317

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North Liberty, IA   

1188 Belmont Dr, Farmington, NY 14425    520-6035878   

Cherry Hill, NJ   

Philadelphia, PA   

Williamstown, NJ   

Flushing, NY   

Schenectady, NY   

New York, NY   

Durham, NC   

Latham, NY   

Chandler, AZ   

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Man Kwok Zhu

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Man Zhu

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Us Patents

Synthesis Of Ccr5 Receptor Antagonists

US Patent:
7728135, Jun 1, 2010
Filed:
Jan 5, 2006
Appl. No.:
11/326154
Inventors:
Xiongwei Shi - Edison NJ, US
Man Zhu - Clark NJ, US
William Leong - Westfield NJ, US
Vilas Dahanukar - Hyderabad, IN
Ilia A. Zavialov - Princeton NJ, US
Cecelia Proietti - Clark NJ, US
Shannon Zhao - Littleton MA, US
Hong-Chang Lee - Livingston NJ, US
Yi Liu - Clark NJ, US
Hoa N. Nguyen - Dayton NJ, US
Wenxue Wu - Princeton Junction NJ, US
Bosco D'Sa - Edison NJ, US
Feng Liang - Monmouth Junction NJ, US
Loc Thanh Tran - Parsippany NJ, US
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07D 401/14
C07D 403/12
A61K 31/506
A61K 31/18
US Classification:
544295, 544364, 544335
Abstract:
The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.

Xinafoate Salt Of A Substituted 5-Oxazol-2-Yl-Quinoline Compound

US Patent:
7919505, Apr 5, 2011
Filed:
Jul 10, 2007
Appl. No.:
11/775383
Inventors:
Pauline C. Ting - New Providence NJ, US
Joe F. Lee - Brooklyn NY, US
Kung-I Feng - Basking Ridge NJ, US
Michael R. Reeder - Skillman NJ, US
Scott T. Trzaska - Raritan NJ, US
Man Zhu - Clark NJ, US
Chen Mao - New Providence NJ, US
Dimitar L. Filipov - Elizabeth NJ, US
Dimitrios N. Zarkadas - Fanwood NJ, US
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07D 215/38
A61K 31/04
US Classification:
514312, 546159, 546163
Abstract:
The present invention relates to the compound of the formula.

Synthesis Of Piperidine And Piperazine Compounds As Ccr5 Antagonists

US Patent:
2004002, Feb 5, 2004
Filed:
Mar 27, 2003
Appl. No.:
10/401070
Inventors:
William Leong - Westfield NJ, US
Minzhang Chen - Plainsboro NJ, US
Bosco D'sa - Edison NJ, US
Man Zhu - Clark NJ, US
Tong Xiao - Edison NJ, US
Xiongwei Shi - Edison NJ, US
Suhan Tang - Plainsboro NJ, US
Dinesh Gala - East Brunswick NJ, US
Andrew Goodman - Annandale NJ, US
Christopher Nielsen - Westfield NJ, US
Gary Lee - Belmont CA, US
Juan Gamboa - New York NY, US
Andrew Jones - Lexington MA, US
Assignee:
Schering Corporation
International Classification:
C 07D 4 1/14
US Classification:
546/187000
Abstract:
In its several embodiments, this invention discloses novel processes to prepare the compounds of formula II and formula IV:

Synthesis Of Piperidine And Piperazine Compounds As Ccr5 Antagonists

US Patent:
2005018, Aug 25, 2005
Filed:
Mar 24, 2005
Appl. No.:
11/088585
Inventors:
William Leong - Westfield NJ, US
Minzhang Chen - Plainsboro NJ, US
Bosco D'sa - Edison NJ, US
Man Zhu - Clark NJ, US
Tong Xiao - Edison NJ, US
Xiongwei Shi - Edison NJ, US
Suhan Tang - Edison NJ, US
Dinesh Gala - East Brunswick NJ, US
Andrew Goodman - Annandale NJ, US
Christopher Nielsen - Westfield NJ, US
Gary Lee - Belmont CA, US
Juan Gamboa - New York NY, US
Andrew Jones - Lexington MA, US
International Classification:
C07D041/14
A61K031/4545
US Classification:
514316000, 546187000
Abstract:
In its several embodiments, this invention discloses novel processes to prepare the compounds of formula II and formula IV:

Synthesis Of Ccr5 Receptor Antagonists

US Patent:
2010003, Feb 11, 2010
Filed:
Oct 16, 2009
Appl. No.:
12/580855
Inventors:
Xiongwei Shi - Edison NJ, US
Man Zhu - Clark NJ, US
William Leong - Westfield NJ, US
Vilas Dahanukar - Hyderabad, IN
Ilia A. Zavialov - Princeton NJ, US
Cecilia Proietti - Westfield NJ, US
Shannon Zhao - Littleton MA, US
Hong-Chang Lee - Livingston NJ, US
Yi Liu - Iselin NJ, US
Hoa N. Nguyen - Dayton NJ, US
Wenxue Wu - Princeton Junction NJ, US
Bosco D'Sa - Edison NJ, US
Feng Liang - Monmouth Junction NJ, US
Loc Thanh Tran - Piscataway NJ, US
International Classification:
C07D 401/06
C07D 211/30
US Classification:
544360, 546248
Abstract:
The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl--piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.

Hydrogen Chloride Salt Of A Substituted 5-Oxazol-2-Yl-Quinoline Compound And A Process For The Production Thereof

US Patent:
2011000, Jan 6, 2011
Filed:
Jul 3, 2008
Appl. No.:
12/668191
Inventors:
Man Zhu - Clark NJ, US
Assignee:
SCHERING CORPORATION - Kenilworth NJ
International Classification:
A61K 31/56
C07D 413/14
A61K 31/4709
A61P 11/00
A61P 11/06
US Classification:
514171, 546167, 514314
Abstract:
The present invention relates to the compound of the Formula I:and to methods of treating upper and lower obstructive airway diseases using said compound, to formulations comprising it, and to a particular crystalline form and processes of synthesis of the crystalline form.IM=105109

Process And Intermediates For The Synthesis Of Heterocyclic Substituted Piperazines With Cxcr3 Antagonist Activity

US Patent:
2011012, May 26, 2011
Filed:
Dec 16, 2008
Appl. No.:
12/809101
Inventors:
Frank Xing Chen - Plainsboro NJ, US
Timothy D. Cutarelli - Clinton NJ, US
Xiayong Fu - Edison NJ, US
Xian Liang - Monmouth Junction NJ, US
Timothy L. McAllister - , US
Robert K. Orr - Cranford NJ, US
Jianguo Yin - Plainsboro NJ, US
Kelvin H. Yong - Lyndhurst NJ, US
Man Zhu - Clark NJ, US
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07D 413/14
C07D 401/14
C07D 403/04
C07D 241/04
C07D 211/44
US Classification:
544357, 544389, 546220
Abstract:
The present invention relates to novel processes for the preparation of the compound of the Formula A45:or a physiologically acceptable salt, solvate or prodrug thereof, which has utility, for example, as a pharmaceutically active compound with CXCR3 antagonist activity, and to novel intermediates useful in the synthesis thereof.

Novel Tetragalnac Containing Conjugates And Methods For Delivery Of Oligonucleotides

US Patent:
2017023, Aug 17, 2017
Filed:
Nov 29, 2016
Appl. No.:
15/363490
Inventors:
- Cambridge MA, US
Steven COLLETTI - West Point PA, US
Vadim DUDKIN - West Point PA, US
Norihiro IKEMOTO - Rahway NJ, US
Hongbiao LIAO - Rahway NJ, US
Craig PARISH - Rahway NJ, US
Tao PEI - Rahway NJ, US
Anthony SHAW - West Point PA, US
Quang TRUONG - Rahway NJ, US
Lijun WANG - Whitehouse Station NJ, US
Yu YUAN - Orlando FL, US
Man ZHU - Rahway NJ, US
International Classification:
C12N 15/113
Abstract:
Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; and optionally, 4) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.

Public records

Vehicle Records

Man Zhu

Address:
1188 Belmont Dr, Farmington, NY 14425
VIN:
WBAVC73527KP32462
Make:
BMW
Model:
3 SERIES
Year:
2007

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