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Mary E Dibiase, 6734 Beaufort St, Providence, RI 02908

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34 Beaufort St, Providence, RI 02908    401-3312884   

Lincoln, RI   

Pawtucket, RI   

Warwick, RI   

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Mary Dibiase Photo 19

Utilization Reviewer

Location:
North Providence, RI
Industry:
Hospital & Health Care
Work:
Bradley Hospital
Utilization Reviewer
Mary Dibiase Photo 20

Mary Jo Dibiase

Publications & IP owners

Us Patents

Stable Liquid Interferon Formulations

US Patent:
2003019, Oct 9, 2003
Filed:
Mar 24, 2003
Appl. No.:
10/397108
Inventors:
Mary DiBiase - Wellesley MA, US
Wen-Li Chung - Arlington MA, US
Mark Staples - Cambridge MA, US
Eric Scharin - Cary NC, US
Assignee:
Biogen, Inc.
International Classification:
A61K038/21
A61M031/00
US Classification:
424/085600, 604/500000
Abstract:
Liquid interferon compositions having a pH between 4.0 and 7.2 are described. The compositions comprise interferon-beta and a stabilizing agent at between about 0.3% and 5% by weight which is an amino acid selected from the group consisting of acidic amino acids, arginine and glycine. If needed, salt is added to provide sufficient ionic strength. The liquid composition has not been previously lyophilized or previously cavitated. The liquid is preferably contained within a vessel having at least one surface in contact with the liquid that is coated with a material inert to adsorption of interferon-beta. A kit for parenteral administration of a liquid interferon formulation and a method for stabilizing liquid interferon compositions are also described.

Stable Liquid Interferon Formulations

US Patent:
2008004, Feb 21, 2008
Filed:
Oct 18, 2007
Appl. No.:
11/975377
Inventors:
Mary DiBiase - Wellesley MA, US
Wen-Li Chung - Arlington MA, US
Mark Staples - Cambridge MA, US
Eric Scharin - Cary NC, US
Assignee:
Biogen Idec MA, Inc. - Cambridge MA
International Classification:
A61K 38/21
US Classification:
424085400
Abstract:
Liquid interferon compositions having a pH between 4.0 and 7.2 are described. The compositions comprise interferon-beta and a stabilizing agent at between about 0.3% and 5% by weight which is an amino acid selected from the group consisting of acidic amino acids, arginine and glycine. If needed, salt is added to provide sufficient ionic strength. The liquid composition has not been previously lyophilized or previously cavitated. The liquid is preferably contained within a vessel having at least one surface in contact with the liquid that is coated with a material inert to adsorption of interferon-beta. A kit for parenteral administration of a liquid interferon formulation and a method for stabilizing liquid interferon compositions are also described.

Stable Liquid Interferon Formulations

US Patent:
2008005, Feb 28, 2008
Filed:
Oct 18, 2007
Appl. No.:
11/975379
Inventors:
Mary DiBiase - Wellesley MA, US
Wen-Li Chung - Arlington MA, US
Mark Staples - Cambridge MA, US
Eric Scharin - Cary NC, US
Assignee:
Biogen Idec MA, Inc. - Cambridge MA
International Classification:
A61K 38/21
US Classification:
424085400
Abstract:
Liquid interferon compositions having a pH between 4.0 and 7.2 are described. The compositions comprise interferon-beta and a stabilizing agent at between about 0.3% and 5% by weight which is an amino acid selected from the group consisting of acidic amino acids, arginine and glycine. If needed, salt is added to provide sufficient ionic strength. The liquid composition has not been previously lyophilized or previously cavitated. The liquid is preferably contained within a vessel having at least one surface in contact with the liquid that is coated with a material inert to adsorption of interferon-beta. A kit for parenteral administration of a liquid interferon formulation and a method for stabilizing liquid interferon compositions are also described.

Stable Liquid Interferon Formulations

US Patent:
2008005, Feb 28, 2008
Filed:
Oct 18, 2007
Appl. No.:
11/975380
Inventors:
Mary DiBiase - Wellesley MA, US
Wen-Li Chung - Arlington MA, US
Mark Staples - Cambridge MA, US
Eric Scharin - Cary NC, US
Assignee:
Biogen Idec MA, Inc. - Cambridge MA
International Classification:
A61K 38/21
US Classification:
424085400
Abstract:
Liquid interferon compositions having a pH between 4.0 and 7.2 are described. The compositions comprise interferon-beta and a stabilizing agent at between about 0.3% and 5% by weight which is an amino acid selected from the group consisting of acidic amino acids, arginine and glycine. If needed, salt is added to provide sufficient ionic strength. The liquid composition has not been previously lyophilized or previously cavitated. The liquid is preferably contained within a vessel having at least one surface in contact with the liquid that is coated with a material inert to adsorption of interferon-beta. A kit for parenteral administration of a liquid interferon formulation and a method for stabilizing liquid interferon compositions are also described.

Method For Delivering Interferon-Beta

US Patent:
2008018, Aug 7, 2008
Filed:
Jan 11, 2006
Appl. No.:
11/795092
Inventors:
Eric Anthony Faulkner - North Andover, US
Mary Diana DiBiase - Wellesley MA, US
Assignee:
BIOGEN IDEC MA INC - Cambridge MA
International Classification:
A61B 19/00
US Classification:
604403
Abstract:
The method described herein reduces the amount of aggregating metal released into solutions of Interferon-β.

Stable Liquid Interferon Formulations

US Patent:
2010023, Sep 23, 2010
Filed:
Jun 4, 2010
Appl. No.:
12/794477
Inventors:
Mary D. DiBiase - Wellesley MA, US
Wen-Li Chung - Arlington MA, US
Mark Staples - Cambridge MA, US
Eric Scharin - Cary NC, US
International Classification:
A61K 38/21
A61P 37/00
US Classification:
424 856
Abstract:
Liquid interferon compositions having a pH between 4.0 and 7.2 are described. The compositions comprise interferon-beta and a stabilizing agent at between about 0.3% and 5% by weight which is an amino acid selected from the group consisting of acidic amino acids, arginine and glycine. If needed, salt is added to provide sufficient ionic strength. The liquid composition has not been previously lyophilized or previously cavitated. The liquid is preferably contained within a vessel having at least one surface in contract with the liquid that is coated with a material inert to adsorption of interferon-beta. A kit for parenteral administration of a liquid interferon formulation and a method for stabilizing liquid interferon compositions are also described.

Method For Delivering Interferon-Beta

US Patent:
2016036, Dec 15, 2016
Filed:
Aug 25, 2016
Appl. No.:
15/246838
Inventors:
- Cambridge MA, US
Mary Diana DiBiase - Wellesley MA, US
Assignee:
Biogen MA Inc. - Cambridge MA
International Classification:
A61K 38/21
A61K 9/00
A61M 5/31
A61K 9/08
Abstract:
The method described herein reduces the amount of aggregating metal released into solutions of Interferon-.beta.

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