Matthew W Sleeman, 34611 Barrett Hill Rd, Mahopac, NY 10541
Matthew Sleeman Phones & Addresses
611 Barrett Hill Rd, Mahopac, NY 10541
Burlington, VT
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Us Patents
Anti-Msr1 Antibodies And Methods Of Use Thereof
US Patent:
2019036, Dec 5, 2019
Filed:
May 8, 2019
Appl. No.:
16/407099
Inventors:
- Tarrytown NY, US
Viktoria Gusarova - Pleasantville NY, US
Amy Han - Hockessin DE, US
Sokol Haxhinasto - Brookfield CT, US
Christos Kyratsous - Irvington NY, US
Andrew J. Murphy - Croton-on Hudson NY, US
Thomas Nittoli - Pearl River NY, US
William Olson - Yorktown Heights NY, US
Matthew Sleeman - White Plains NY, US
Anna Zumsteg - Elmsford NY, US
Viktoria Gusarova - Pleasantville NY, US
Amy Han - Hockessin DE, US
Sokol Haxhinasto - Brookfield CT, US
Christos Kyratsous - Irvington NY, US
Andrew J. Murphy - Croton-on Hudson NY, US
Thomas Nittoli - Pearl River NY, US
William Olson - Yorktown Heights NY, US
Matthew Sleeman - White Plains NY, US
Anna Zumsteg - Elmsford NY, US
International Classification:
C07K 16/28
A61K 47/68
A61K 31/58
A61K 31/165
A61K 31/167
A61K 31/417
A61K 31/5383
A61K 31/4985
A61K 47/61
A61K 47/60
A61P 9/10
A61P 19/02
A61P 3/06
A61P 31/04
A61K 38/14
A61K 39/395
A61P 37/06
A61K 47/68
A61K 31/58
A61K 31/165
A61K 31/167
A61K 31/417
A61K 31/5383
A61K 31/4985
A61K 47/61
A61K 47/60
A61P 9/10
A61P 19/02
A61P 3/06
A61P 31/04
A61K 38/14
A61K 39/395
A61P 37/06
Abstract:
Provided herein are antibodies and antigen-binding fragments that bind MSR1 and methods of use thereof. According to certain embodiments, the antibodies bind human MSR1 with high affinity. In certain embodiments, the antibodies bind MSR1 without blocking, or blocking less than 90%, of modified LDL binding to MSR1. In some embodiments, the antibodies bind cell surface expressed-MSR1 and are internalized. The antibodies of the invention may be fully human antibodies. The invention includes anti-MSR1 antibodies, or antigen-binding fragments thereof, conjugated to drugs or therapeutic compounds.
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