Meilin LiuSan Antonio, TX
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San Antonio, TX
Flushing, NY
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Us Patents
Human Anti-Epidermal Growth Factor Receptor Antibody
US Patent:
7598350, Oct 6, 2009
Filed:
Mar 21, 2005
Appl. No.:
10/593804
Inventors:
Meilin Liu - Brooklyn NY, US
Zhenping Zhu - Oakland NJ, US
Zhenping Zhu - Oakland NJ, US
Assignee:
ImClone LLC - New York NY
International Classification:
C07K 16/28
US Classification:
5303879
Abstract:
The present invention provides a fully human antibody that binds human EGFR with affinity comparable to or higher than IMC-C225, and that neutralizes activation of EGFR. Antibodies include whole immunoglobulins, monovalent Fabs and single chain antibodies, multivalent single chains antibodies, diabodies, triabodies, and single domain antibodies. The invention further provides nucleic acids and host cells and animals that encode and express these antibodies. The invention further provides a method for neutralizing activation of EGFR, treating in a mammal with neoplastic growth and non-cancerous hyperproliferative diseases using the antibodies alone or in combination with other agents.
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