Meng M Xu, 47Garden City, NY

2018021, Aug 2, 2018

Jan 31, 2018

15/885408

- Hoboken NJ, US
Meng Xu - Secaucus NJ, US
Deep Parikh - South Plainfield NJ, US
Jin Zou - Rutherford NJ, US
Weiwei Wang - Jersey City NJ, US

THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY - Hoboken NJ

A61L 27/36
A61L 27/56
G01N 33/50
C12N 5/00

In accordance with the method of the present invention, 3D tissue-derived scaffolding materials are made in various formats, including but not limited to hydrogel, sponge, fibers, microspheres, and films, all of which function to better preserve natural extracellular matrix molecules and to mimic the natural tissue environment, thereby effectively guiding tissue regeneration. The method involves incorporating a homogenized tissue-derived suspension into a polymeric solution of synthetic, natural, or hybrid polymers to prepare tissue-derived scaffolds in the aforementioned formats. Such tissue-derived scaffolds and scaffolding materials have a variety of utilities, including: the creation of 3D tissue models such as skin, bone, liver, pancreas, lung, and so on; facilitation of studies on cell-matrix interactions; and the fabrication of implantable scaffolding materials for guided tissue formation in vivo. The tissue-derived scaffolds and scaffolding materials made in accordance with the present invention also provide the opportunity to correlate the functions of extracellular matrix with tissue regeneration and cancer metastasis, for example.