Michael E Chan1651 Turnberry Dr, Pickerington, OH 43147

6376664, Apr 23, 2002

Mar 17, 2000

09/528273

Michael K. Chan - Hilliard OH
Wai H. Kwok - Kowloon, KR
Huichang Zhang - Charlottesville VA
Maosheng Duan - Cary NC

The Ohio State University - Columbus OH

C07D22500

540465, 540472, 540476, 5462731

Cyclic bis benzimidazole ligands of the following formula are formed by contacting a (2-aminophenyl)-benzimidazole-4-carboxaldehyde ethylene acetal or a (2-nitrophenyl)-benzimidazole-4-benzaldehyde with an acid optionally in the presence of a metal or a metal salt. wherein R and R may be the same or different and are selected from H, an alkyl having 1 to 10 carbon atoms, a benzyl group, a substituted 2-ethylphenyl group, a carbonyl group, a phenyl substituent, a tosyl group, and an alkylsulfonate group; R and R may be the same or different and are selected from H, methyl, and ethyl; and R , R , R , R , R , R , R , R , R , R , R , R , R , and R may be the same or different and are selected from H, alkyl having 1 to 10 carbon atoms, fluoride, chloride, bromide, iodide, nitro, amino, a carboxylate, an ester, and a phenyl group.

2005023, Oct 27, 2005

Oct 28, 2004

10/978082

Michael Chan - Hilliard OH, US
Tomasz Fekner - Lublin, PL

A61K031/553
A61K031/551
H01L051/40
C07F009/80
C07D491/04
C07D487/04

514211100, 540546000, 540556000, 548102000, 548111000, 514219000, 438099000

A new class of tetracylic benzimidazole compounds and derivatives thereof. Additionally provided is a synthetic route for the generation of these and related compounds via Intramolecular Aromatic Nucleophilic Substitution (SAr) of the Benzimidazole-Activated Nitro Groups. Additionally, a facile route for the generation of novel phenol species as thermal decomposition of compounds the SAr product, which occurs at high temperature resulting in cleavage of the ether linkage and formation of a vinyl group and phenol is provided. Also provided are methods of using the compounds described herein in the treatment HIV.

2006016, Jul 27, 2006

Aug 15, 2005

11/204295

Michael Chan - Hilliard OH, US
Joseph Krzycki - Columbus OH, US

C12P 21/06
C12N 15/74
C12N 1/21

435069100, 435483000, 435252300

Provided herein is a method for preparing a cell that, when exposed to the non-canonical amino acid, pyrrolysine or a derivative thereof and transformed or transfected with a polynucleotide comprising an in-frame UAG or TAG codon incorporates the pyrrolysine residue or derivative thereof into the protein or polynucleotide into the protein or polypeptide encoded by the polynucleotide. The method comprises introducing a first polynucleotide comprising a sequence that encodes a protein having pyrrolysyl-tRNA synthetase activity and a second polynucleotide comprising a sequence that encodes a pyrrolysine specific tRNA into the cell and maintining the cell under conditions that permit expression of the first and second polynucleotide. Also provided herein are modified cells produced in accordance with the present method and methods of making peptides, polypeptides, and proteins which utilize such modified cells. Also provide are kits comprising pyrrolysine or a pyrrolysine or both. The kits also provide the first polynucleotide and the second polynucelotide or cells produced in accordance with the present methods or both.

2006018, Aug 17, 2006

Aug 15, 2005

11/203820

Michael Chan - Hilliard OH, US
Joseph Krzycki - Columbus OH, US

C07K 14/47
C07D 207/12

530409000, 548537000, 548303700

Synthetic L-pyrrolysine of formula I, and derivatives thereof, chemical methods of preparing these amino acids and derivatives, and methods of derivatizing these amino acids after incorporation into a peptide or protein. Also provided are derivatives and methods of preparing derivatives, including addition of substituents at any substitutable position; modifications to the lysine alkyl chain; modifications of the pyrroline ring. Also provided are methods of adding labels to the pyrrolysine or derivative thereof.

2010032, Dec 23, 2010

Jun 7, 2010

12/795485

Michael K. Chan - Hilliard OH, US
Manoj S. Nair - Columbus OH, US
Marianne M. Lee - Hilliard OH, US

THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION - Columbus OH

A61K 38/02
C12N 1/20
C12N 5/04
C12N 9/00
C07K 2/00
C07H 21/00
C12N 15/63
C12P 21/00
A61P 37/02

4242821, 4352521, 435410, 435183, 530350, 536 234, 4353201, 514 11, 435 697

Embodiments exploit the ability of the organism to produce regularly shaped micrometer-sized crystals of Cry insect protoxins. In various embodiments, these crystals are used as a platform to generate various compositions that are useful for numerous applications.

2013003, Feb 7, 2013

Oct 6, 2010

13/500695

Michael K. Chan - Hilliard OH, US
Tomasz Fekner - Lublin, PL
Xin Li - Albany CA, US
Marianne Lee - Hilliard OH, US
Manoj Nair - Columbus OH, US
Jennifer Jo Ottensen - Worthington OH, US

The Ohio State University - Columbus OH

C07K 5/068
C07C 247/04

534558, 562561, 548960, 548146

Several different pyrrolysine analogs are disclosed in this application. Those analogs have distinct chemical and biophysical properties. Some analogs are useful in chemical ligation applications. Methods of making and using are also disclosed.