Michael E Elmore, 68764 Lake Meadow Dr, Collierville, TN 38017

6576629, Jun 10, 2003

Aug 6, 1999

09/369298

David Oppong - Cordova TN
Marilyn S. Whittemore - Memphis TN
M. Sheldon Ellis - Cordova TN
Michael E. Elmore - Collierville TN

Buckman Laboratories International, Inc. - Memphis TN

A61K 31535

5142312, 514383

A method for increasing the effectiveness of the microbicide propiconazole, (RS)-1-2-[(2,4-dichlorophenyl)-2-propyl-1,3-dioxalan-2ylmethyl]-1H-1,2,4-triazole, is described. In the method, propiconazole and a potentiator, an N-alkyl heterocyclic compound, its salt, or a mixture thereof, are applied to a substrate or aqueous system subject to the growth of microorganisms. The N-alkyl heterocyclic compound, its salt, or a mixture thereof is applied in an amount effective to increase the microbicidal activity of the microbicide. The N-alkyl heterocyclic compound has the formula: The variable ânâ ranges from 5 to 17, and the heterocyclic ring defined by is a substituted or unsubstituted ring having four to eight members. Microbicidal compositions are described where propiconazole and an N-alkyl heterocyclic compound, its salt, or a mixture thereof are present in a combined amount: effective to control the growth of at least one microorganism. Methods for controlling the growth of microorganisms on various substrates and in various aqueous systems are also described.