Michael D Sintchak, 5934 Lloyd St, Winchester, MA 01890
Michael Sintchak Phones & Addresses
34 Lloyd St, Winchester, MA 01890 781-7292136
45 Vine St, Winchester, MA 01890 781-7292136
Tamarac, FL
Arlington, MA
Somerville, MA
Hamden, CT
Kings Park, NY
34 Lloyd St, Winchester, MA 01890 781-4240372
Work
Position:
Professional/Technical
Education
Degree:
High school graduate or higher
Emails
Mentions for Michael D Sintchak
Publications & IP owners
Us Patents
Molecules Comprising A Calcineurin-Like Binding Pocket And Encoded Data Storage Medium Capable Of Graphically Displaying Them
US Patent:
7065452, Jun 20, 2006
Filed:
Nov 1, 1999
Appl. No.:
09/431469
Inventors:
David M. Armistead - Maynard MA, US
Matthew James Fitzgibbon - Millis MA, US
Mark Andrew Fleming - Cambridge MA, US
James P. Griffith - Weston MA, US
Eunice E. Kim - Framingham MA, US
Joseph L. Kim - Natick MA, US
Michael D. Sintchak - Winchester MA, US
John Allan Thomson - Belmont MA, US
Keith P. Wilson - Hopkinton MA, US
Matthew James Fitzgibbon - Millis MA, US
Mark Andrew Fleming - Cambridge MA, US
James P. Griffith - Weston MA, US
Eunice E. Kim - Framingham MA, US
Joseph L. Kim - Natick MA, US
Michael D. Sintchak - Winchester MA, US
John Allan Thomson - Belmont MA, US
Keith P. Wilson - Hopkinton MA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
G06G 7/48
G06N 7/06
G06N 7/06
US Classification:
702 27, 703 2
Abstract:
The present invention relates to crystallized molecules and molecular complexes which comprise the active site binding pocket or the FKBP12/FK506 binding pocket of calcineurin or close structural homologues to either binding pocket. This invention also relates to a data storage material encoded with the corresponding structure coordinates of those crystallized molecules or molecular complexes. Such data storage material is capable of displaying such molecules and molecular complexes as a graphical three-dimensional representation on a computer screen. In addition, this invention relates to methods of using the structure coordinates of those molecules or molecular complexes to solve the structure of homologous proteins. This invention also relates to methods of using the structure coordinates to screen and design compounds that bind to calcineurin or homologues thereof.
Methods Of Using The Structure Coordinates Of Molecules Comprising An Impdh-Like Binding Pocket
US Patent:
7216041, May 8, 2007
Filed:
Oct 2, 2000
Appl. No.:
09/678016
Inventors:
Keith P. Wilson - Hopkinton MA, US
Michael D. Sintchak - Winchester MA, US
Mark Andrew Fleming - Cambridge MA, US
David M. Armistead - Maynard MA, US
Michael D. Sintchak - Winchester MA, US
Mark Andrew Fleming - Cambridge MA, US
David M. Armistead - Maynard MA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
G06F 19/00
US Classification:
702 27, 702 19, 702 20
Abstract:
The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.
Crystals Of Inosine Monophosphate Dehydrogenase/Oxidized Inosine Monophosphate Thiomidate Intermediate/Mycophenolic Acid (Iimpdh/Xmp*/Mpa)
US Patent:
7527952, May 5, 2009
Filed:
Dec 21, 2006
Appl. No.:
11/645289
Inventors:
Keith P. Wilson - La Jolla CA, US
Michael D. Sintchak - Winchester MA, US
Mark Andrew Fleming - Winchester MA, US
David M. Armistead - Sudbury MA, US
Michael D. Sintchak - Winchester MA, US
Mark Andrew Fleming - Winchester MA, US
David M. Armistead - Sudbury MA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
C12P 21/06
C12N 9/04
C12N 9/04
US Classification:
435190, 435 691
Abstract:
The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.
Molecules Comprising A Calcineurin-Like Binding Pocket And Encoded Data Storage Medium Capable Of Graphically Displaying Them
US Patent:
2007001, Jan 11, 2007
Filed:
Jun 19, 2006
Appl. No.:
11/471290
Inventors:
David Armistead - Maynard MA, US
Matthew Fitzgibbon - Millis MA, US
Mark Fleming - Cambridge MA, US
James Griffith - Weston MA, US
Eunice Kim - Framingham MA, US
Joseph Kim - Natick MA, US
Michael Sintchak - Winchester MA, US
John Thomson - Belmont MA, US
Keith Wilson - Hopkinton MA, US
Matthew Fitzgibbon - Millis MA, US
Mark Fleming - Cambridge MA, US
James Griffith - Weston MA, US
Eunice Kim - Framingham MA, US
Joseph Kim - Natick MA, US
Michael Sintchak - Winchester MA, US
John Thomson - Belmont MA, US
Keith Wilson - Hopkinton MA, US
International Classification:
G06F 19/00
C07K 14/705
C07K 14/705
US Classification:
702019000, 530350000
Abstract:
The present invention relates to crystallized molecules and molecular complexes which comprise the active site binding pocket or the FKBP12/FK506 binding pocket of calcineurin or close structural homologues to either binding pocket. This invention also relates to a data storage material encoded with the corresponding structure coordinates of those crystallized molecules or molecular complexes. Such data storage material is capable of displaying such molecules and molecular complexes as a graphical three-dimensional representation on a computer screen. In addition, this invention relates to methods of using the structure coordinates of those molecules or molecular complexes to solve the structure of homologous proteins. This invention also relates to methods of using the structure coordinates to screen and design compounds that bind to calcineurin or homologues thereof.
Heteroaryls And Uses Thereof
US Patent:
2013016, Jun 27, 2013
Filed:
Dec 20, 2012
Appl. No.:
13/722134
Inventors:
MILLENNIUM PHARMACEUTICALS, INC. - Cambridge MA, US
Courtney A. Cullis - Bedford MA, US
Matthew O. Duffey - Cambridge MA, US
Krista E. Gipson - Medford MA, US
Yongbo Hu - Winchester MA, US
Gang Li - Westborough MA, US
Michael D. Sintchak - Winchester MA, US
Tricia J. Vos - Winchester MA, US
Courtney A. Cullis - Bedford MA, US
Matthew O. Duffey - Cambridge MA, US
Krista E. Gipson - Medford MA, US
Yongbo Hu - Winchester MA, US
Gang Li - Westborough MA, US
Michael D. Sintchak - Winchester MA, US
Tricia J. Vos - Winchester MA, US
Assignee:
MILLENNIUM PHARMACEUTICALS, INC. - Cambridge MA
International Classification:
C07D 401/14
C07D 401/04
C07D 471/04
A61K 31/444
C07D 403/04
A61K 31/506
A61K 45/06
A61K 31/4439
A61K 31/437
C07D 401/04
C07D 471/04
A61K 31/444
C07D 403/04
A61K 31/506
A61K 45/06
A61K 31/4439
A61K 31/437
US Classification:
514275, 5462724, 514341, 5462791, 514343, 546113, 514300, 5462754, 544324, 5462727, 5462764, 546256, 514333
Abstract:
This invention provides compounds of formula IB:and also provides compounds of formulas ID, IIB, VB, and IIC:wherein HY, R, R, G, G, G, G, and Gare as described in the specification. The compounds are inhibitors of VPS34 and/or PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
Heteroaryls And Uses Thereof
US Patent:
2013016, Jun 27, 2013
Filed:
Dec 20, 2012
Appl. No.:
13/721877
Inventors:
MILLENNIUM PHARMACEUTICALS, INC. - Cambridge MA, US
Courtney A. Cullis - Bedford MA, US
Matthew O. Duffey - Cambridge MA, US
Krista E. Gipson - Medford MA, US
Yongbo Hu - Winchester MA, US
Gang Li - Westborough MA, US
Michael D. Sintchak - Winchester MA, US
Tricia J. Vos - Winchester MA, US
Courtney A. Cullis - Bedford MA, US
Matthew O. Duffey - Cambridge MA, US
Krista E. Gipson - Medford MA, US
Yongbo Hu - Winchester MA, US
Gang Li - Westborough MA, US
Michael D. Sintchak - Winchester MA, US
Tricia J. Vos - Winchester MA, US
Assignee:
MILLENNIUM PHARMACEUTICALS, INC. - Cambridge MA
International Classification:
C07D 401/04
A61K 45/06
A61K 31/444
A61K 31/4375
C07D 401/14
A61K 31/4439
C07D 471/14
A61K 45/06
A61K 31/444
A61K 31/4375
C07D 401/14
A61K 31/4439
C07D 471/14
US Classification:
514293, 5462747, 514341, 546 82, 546256, 514333
Abstract:
This invention provides compounds of formula IA:and also provides compounds of formula IIA, IIIA, IVA, or VA:
Heteroaryls And Uses Thereof
US Patent:
2013016, Jun 27, 2013
Filed:
Dec 20, 2012
Appl. No.:
13/722222
Inventors:
Millennium Pharmaceuticals, Inc. - Cambridge MA, US
Courtney A. Cullis - Bedford MA, US
Matthew O. Duffey - Cambridge MA, US
Krista E. Gipson - Medford MA, US
Yongbo Hu - Winchester MA, US
Gang Li - Westborough MA, US
Michael D. Sintchak - Winchester MA, US
Stephen G. Stroud - Medford MA, US
Tricia J. Vos - Winchester MA, US
Courtney A. Cullis - Bedford MA, US
Matthew O. Duffey - Cambridge MA, US
Krista E. Gipson - Medford MA, US
Yongbo Hu - Winchester MA, US
Gang Li - Westborough MA, US
Michael D. Sintchak - Winchester MA, US
Stephen G. Stroud - Medford MA, US
Tricia J. Vos - Winchester MA, US
Assignee:
MILLENNIUM PHARMACEUTICALS, INC. - Cambridge MA
International Classification:
A61K 31/4439
A61K 45/06
A61K 31/444
C07D 417/14
C07D 401/04
C07D 401/14
A61K 45/06
A61K 31/444
C07D 417/14
C07D 401/04
C07D 401/14
US Classification:
514333, 5462741, 514341, 5462724, 514340, 5462791, 514343, 546256, 5462707
Abstract:
This invention provides compounds of formula IB:wherein HY, R, R, R, R, G, G, G, G, and Gare as described in the specification. The compounds are inhibitors of VPS34 and/or PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
Molecules Comprising An Impdh-Like Binding Pocket And Encoded Data Storage Medium Capable Of Graphically Displaying Them
US Patent:
6128582, Oct 3, 2000
Filed:
Apr 30, 1996
Appl. No.:
8/640164
Inventors:
Keith P. Wilson - Hopkinton MA
Michael D. Sintchak - Winchester MA
Mark Andrew Fleming - Cambridge MA
David M. Armistead - Maynard MA
Michael D. Sintchak - Winchester MA
Mark Andrew Fleming - Cambridge MA
David M. Armistead - Maynard MA
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
G06F 1900
US Classification:
702 27
Abstract:
The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.
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