Michael R Tomasco, 67Gardnerville, NV

6464849, Oct 15, 2002

Oct 7, 1999

09/414060

James L. Say - Alameda CA
Michael F. Tomasco - Danville CA

Pepex Biomedical, L.L.C. - Ada MI

G01N 2726

20440314, 20440315, 20440301

The present disclosure relates to a sensor including a bundle of electrically conductive fibers. The sensor also includes a sensing material coating at least some of the fibers in the bundle, and an insulating layer that surrounds the bundle of electrically conductive fibers.

6484046, Nov 19, 2002

Jul 10, 2000

09/613604

James Say - Alameda CA
Michael F. Tomasco - Cupertino CA
Adam Heller - Austin TX
Yoram Gal - Kibbutz Yagur, IL
Behrad Aria - Alameda CA
Ephraim Heller - Oakland CA
Phillip John Plante - Sunnyvale CA
Mark S. Vreeke - Alameda CA

TheraSense, Inc. - Alameda CA

A61B 505

600345, 600347, 600309, 600365

An electrochemical analyte sensor having conductive traces on a substrate is used to determine a level of analyte in in vitro or in vivo analyte-containing fluids. The electrochemical analyte sensor includes a substrate and conductive material disposed on the substrate, the conductive material forming a working electrode. In some sensors, the conductive material is disposed in recessed channels formed in a surface of the sensor. An electron transfer agent and/or catalyst may be provided to facilitate the electrolysis of the analyte or of a second compound whose level depends on the level of the analyte. A potential is formed between the working electrode and a reference electrode or counter/reference electrode and the resulting current is a function of the concentration of the analyte in the fluid.

6565509, May 20, 2003

Sep 21, 2000

09/667199

James Say - Alameda CA
Michael F. Tomasco - Cupertino CA
Adam Heller - Austin TX
Yoram Gal - Kibbutz Yagur, IL
Behrad Aria - Alameda CA
Ephraim Heller - Oakland CA
Phillip John Plante - Sunnyvale CA
Mark S. Vreeke - Alameda CA
Keith A. Friedman - Austin TX
Fredric C. Colman - Berkeley CA

TheraSense, Inc. - Alameda CA

A61B 500

600365, 600347, 600345

An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

6654625, Nov 25, 2003

Jun 16, 2000

09/595708

James L. Say - Alameda CA
Michael F. Tomasco - Danville CA
Jay D. Audett - Mountain View CA
Hyun Cho - Berkeley CA
Duane O. Yamasaki - El Cerrito CA
Adam Heller - Austin TX

TheraSense, Inc. - Alameda CA

A61B 505

600347, 600345, 600365

An in vivo electrochemical sensor including a working electrode, and an analyte-responsive sensing layer proximate the working electrode. The sensing layer is exposed at an edge of the sensor, wherein the sensor signal is limited, at least in part, by mass transport of analyte to the sensing layer. The sensor is configured and arranged for implantation into the body of a mammal for contact with body fluids of the mammal. The analyte diffuses to the sensing element via the edge of the sensor, thereby restricting mass transport of the analyte to the sensing element. This is because the solution-contacting surface area of the sensor edge is much smaller than an open face of the sensing layer.

6973706, Dec 13, 2005

Mar 31, 2003

10/405765

James Say - Alameda CA, US
Michael F. Tomasco - Cupertino CA, US
Adam Heller - Austin TX, US
Yoram Gal - Kibbutz Yagur, IL
Behrad Aria - Alameda CA, US
Ephraim Heller - Oakland CA, US
Phillip John Plante - Sunnyvale CA, US
Mark S. Vreeke - Alameda CA, US

TheraSense, Inc. - Alameda CA

G01R003/00

29595, 29417, 295921, 29831, 29846, 156 731, 216 65, 3612831, 3612832, 427 79, 427 80

A process for the manufacture of small sensors with reproducible surfaces, including electrochemical sensors. One process includes fanning channels in the surface of a substrate and disposing a conductive material in the channels to form an electrode. The conductive material can also be formed on the substrate by other impact and non-impact methods. In a preferred embodiment, the method includes cutting the substrate to form a sensor having a connector portion and a transcutaneous portion, the two portions having edges that define one continuous straight line.

6975893, Dec 13, 2005

Nov 25, 2003

10/723381

James L. Say - Alameda CA, US
Michael F. Tomasco - Danville CA, US
Jay D. Audett - Mountain View CA, US
Hyun Cho - Berkeley CA, US
Duane O. Yamasaki - El Cerrito CA, US
Adam Heller - Austin TX, US

TheraSense, Inc. - Alameda CA

A61B005/05

600347, 600345, 600365, 600373

An in vivo electrochemical sensor including a working electrode, and an analyte-responsive sensing layer proximate the working electrode. The sensing layer is exposed at an edge of the sensor, wherein the sensor signal is limited, at least in part, by mass transport of analyte to the sensing layer. The sensor is configured and arranged for implantation into the body of a mammal for contact with body fluids of the mammal. The analyte diffuses to the sensing element via the edge of the sensor, thereby restricting mass transport of the analyte to the sensing element. This is because the solution-contacting surface area of the sensor edge is much smaller than an open face of the sensing layer.

6990366, Jan 24, 2006

Nov 24, 2003

10/722264

James Say - Alameda CA, US
Michael F. Tomasco - Cupertino CA, US
Adam Heller - Austin TX, US
Yoram Gal - Kibbutz Yagur, IL
Behrad Aria - Alameda CA, US
Ephraim Heller - Oakland CA, US
Phillip John Plante - Sunnyvale CA, US
Mark S. Vreeke - Alameda CA, US
Keith A. Friedman - Austin TX, US
Fredric C. Colman - Berkeley CA, US

TheraSense, Inc. - Alameda CA

A61B 5/05

600345, 600347, 600360, 600357

An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

7003340, Feb 21, 2006

Nov 11, 2002

10/291969

James Say - Alameda CA, US
Michael F. Tomasco - Cupertino CA, US
Adam Heller - Austin TX, US
Yoram Gal - Kibbutz Yagur, IL
Behrad Aria - Alameda CA, US
Ephraim Heller - Oakland CA, US
Phillip John Plante - Sunnyvale CA, US
Mark S. Vreeke - Alameda CA, US

Abbott Diabetes Care Inc. - Alameda CA

A61B 5/05
A61B 5/04

600345, 60372, 60354, 60357

An electrochemical analyte sensor formed using conductive traces on a substrate can be used for determining and/or monitoring a level of analyte in in vitro or in vivo analyte-containing fluids. For example, an implantable sensor may be used for the continuous or automatic monitoring of a level of an analyte, such as glucose, lactate, or oxygen, in a patient. The electrochemical analyte sensor includes a substrate and conductive material disposed on the substrate, the conductive material forming a working electrode. In some sensors, the conductive material is disposed in recessed channels formed in a surface of the sensor. An electron transfer agent and/or catalyst may be provided to facilitate the electrolysis of the analyte or of a second compound whose level depends on the level of the analyte. A potential is formed between the working electrode and a reference electrode or counter/reference electrode and the resulting current is a function of the concentration of the analyte in the body fluid.