Min Jung Park, 491050 Cumbermeade Rd, West Fort Lee, NJ 07024

6767915, Jul 27, 2004

Jan 27, 2003

10/343040

Raman K. Bakshi - Edison NJ
Khaled J. Barakat - Brooklyn NY
Yingjie Lai - Edison NJ
Ravi P. Nargund - East Brunswick NJ
Brenda L. Palucki - Hillsborough NJ
Min K. Park - Whippany NJ
Iyassu K. Sebhat - New York NY
Zhixiong Ye - Princeton NJ
Arthur A. Patchett - Westfield NJ

Merck Co., Inc. - Rahway NJ

A61K 31445

514325, 546203, 546205, 546202, 546199, 546198, 546194, 514330, 514324, 514322, 514318, 514326

Certain novel 4-substituted piperidine compounds are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

7326726, Feb 5, 2008

Mar 12, 2004

10/799230

Prasun K. Chakravarty - Edison NJ, US
Louis L. Zuegner III, legal representative - Flemington NJ, US
Brenda Palucki - Hillsborough NJ, US
Min K. Park - Whippany NJ, US
William H. Parsons - Belle Mead NJ, US
Bishan Zhou - Hoboken NJ, US

Merck & Co., Inc. - Rahway NJ

A61K 31/41
C07D 249/08

514359, 5482694

Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

7414057, Aug 19, 2008

Sep 5, 2003

10/526178

Raman Kumar Bakshi - Edison NJ, US
Ravi P. Nargund - East Brunswick NJ, US
Brenda L. Palucki - Hillsborough NJ, US
Min K. Park - Whippany NJ, US
Zhixiong Ye - Princeton NJ, US

Merck & Co., Inc. - Rahway NJ

C07D 401/12
C07D 403/12
A61K 31/453
A61K 31/4545
A61P 3/04
A61P 3/10

51425213, 544360

Certain novel piperazine urea derivatives are agonists of the human melanocortin-4 receptor (MC-4R) and, in particular, are receptor-subtype selective agonists of MC-4R. They are useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity and diabetes.

7459475, Dec 2, 2008

Nov 10, 2004

10/985592

Min K. Park - Whippany NJ, US
Prasun K. Chakravarty - Edison NJ, US
Bishan Zhou - Hoboken NJ, US
Edward Gonzalez - Iselin NJ, US
Hyun Ok - Colonia NJ, US
Brenda Palucki - Hillsborough NJ, US
William H. Parsons - Belle Mead NJ, US
Rosemary Sisco - Old Bridge NJ, US

Merck & Co. Inc. - Rahway NJ

A61K 31/41
C07D 249/08

514383, 5482622

Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, migraine, headache pain, migraine headache, epilepsy, irritable bowel syndrome, diabetic neuropathy, multiple sclerosis, manic depression and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

7572822, Aug 11, 2009

Jan 30, 2008

12/011967

Prasun K. Chakravarty - Edison NJ, US
William H. Parsons - Belle Mead NJ, US
Brenda Palucki - Hillsborough NJ, US
Bishan Zhou - Edison NJ, US
Min K. Park - Whippany NJ, US

Merck & Co. Inc. - Rahway NJ

A61K 31/4196
A61K 31/41
C07D 249/08

514383, 5482622, 5482668

Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

2006018, Aug 17, 2006

Mar 12, 2004

10/549790

Prasun Chakravarty - Edison NJ, US
Michael Fisher - Ringoes NJ, US
Brenda Palucki - Hillsborough NJ, US
Min Park - Whippany NJ, US
William Parsons - Belle Mead NJ, US
Bishan Zhou - Hoboken NJ, US
James Carey - Downingtown PA, US
Douglas Frantz - Downingtown PA, US
Michael Kress - Exton PA, US
Damian Weaver - Lansdale PA, US

C07D 417/02
C07D 403/02
C07D 413/02

544132000, 544405000, 544366000, 546272400, 544333000, 546210000, 548200000, 548131000, 548215000, 548266200

Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

2009007, Mar 19, 2009

Nov 5, 2004

10/578950

Min K. Park - Whippany NJ, US
Prasun K. Chakravarty - Edison NJ, US
Bishan Zhou - Hoboken NJ, US
Edward Gonzalez - Iselin NJ, US
Hyun Ok - Colonia NJ, US
Brenda Palucki - Hillsborough NJ, US
William H. Parsons - Belle Mead NJ, US
Rosemary Sisco - Old Bridge NJ, US
Michael H. Fisher - Ringoes NJ, US

C07D 249/08
A61P 29/00
A61P 9/00
A61P 25/00
A61K 33/00
A61K 31/4196
A61P 1/00
A61P 31/12
A61P 37/00

424722, 5482668, 514383

Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, migraine, headache pain, migraine headache, epilepsy, irritable bowel syndrome, diabetic neuropathy, multiple sclerosis, manic depression and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier (I), (II), (III).

2010008, Apr 8, 2010

Apr 22, 2008

12/597081

Prasun K. Chakravarty - Edison NJ, US
Joseph L. Duffy - Cranford NJ, US
Min K. Park - Whippany NJ, US
Sriram Tyagarajan - Edison NJ, US
Bishan Zhou - Hoboken NJ, US

A61K 31/404
C07D 209/04
C07D 401/04
C07D 403/06
A61K 31/4439
A61K 31/496
A61P 25/00
A61P 25/08

51425409, 548510, 5462774, 544373, 514415, 514339

2-Substituted indole derivatives represented by Formula I, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, calcium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, urinary incontinence, itchiness, allergic dermatitis, epilepsy, diabetic neuropathy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, bipolar disorder and stroke, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds.