Min Xu, 57103 York Dr, Princeton, NJ 08540

7196163, Mar 27, 2007

Apr 30, 2003

10/427208

Daria Jean Hazuda - Doylestown PA, US
Elizabeth Chen Dodson - Souderton PA, US
Min Xu - Ambler PA, US
Xiao-Ping Shi - Warrington PA, US
Adam J. Simon - Langhorne PA, US
Guoxin Wu - Merion Station PA, US
Yueming Li - New York NY, US
Bruce Register - Berwyn PA, US

Merk & Co., Inc. - Rahway NJ

A61K 38/07
A61K 38/16

530330, 530350, 514 2, 514 18, 435 71, 424 9463

Provided are methods of identifying inhibitors of β-secretase that employ modified β-secretase substrates. The modified β-secretase substrates have β-secretase cleavage sites that are altered from wild type. The amino acid sequences of the altered β-secretase cleavage sites contain different amino acids in at least one of the positions P2-P1-P1′-P2′ of the β-secretase cleavage site. Many of the modified β-secretase substrates are more efficient substrates for β-secretase than are corresponding substrates having wild-type sequences, that is, these modified substrates are more susceptible to enzymatic breakdown by β-secretase. Recombinant polynucleotide molecules encoding the modified β-secretase substrates are provided. Antibodies that recognize cleavage products of the modified β-secretase substrates are provided. Stable cell lines expressing the modified β-secretase substrates are provided.

2007021, Sep 20, 2007

Mar 7, 2007

11/714985

Daria Hazuda - Doylestown PA, US
Elizabeth Chen Dodson - Souderton PA, US
Min Xu - Ambler PA, US
Xiao-Ping Shi - Warrington PA, US
Adam Simon - Langhorne PA, US
Guoxin Wu - Merion Station PA, US
Yueming Li - New york NY, US
Bruce Register - Berwyn PA, US

C07K 16/00
C07K 14/00

530387900, 530395000

Provided are methods of identifying inhibitors of β-secretase that employ modified β-secretase substrates. The modified β-secretase substrates have β-secretase cleavage sites that are altered from wild type. The amino acid sequences of the altered β-secretase cleavage sites contain different amino acids in at least one of the positions P2-P1-P1′-P2′ of the β-secretase cleavage site. Many of the modified β-secretase substrates are more efficient substrates for β-secretase than are corresponding substrates having wild-type sequences, that is, these modified substrates are more susceptible to enzymatic breakdown by β-secretase. Recombinant polynucleotide molecules encoding the modified β-secretase substrates are provided. Antibodies that recognize cleavage products of the modified β-secretase substrates are provided. Stable cell lines expressing the modified β-secretase substrates are provided. Transgenic animals expressing the modified β-secretase substrates are provided.

2009022, Sep 3, 2009

Aug 8, 2006

11/990174

Amy Espeseth - Chalfont PA, US
Daria J. Hazuda - Doylestown PA, US
Min Xu - Ambler PA, US

A61K 31/7088
C40B 30/04
C12Q 1/70

514 44 R, 506 9, 435 5

Using a method to measure the effect of downregulation of certain cellular proteins on HIV integration, host proteins implicated in HIV infection were identified. The identified proteins and encoding nucleic acids provide targets for inhibiting HIV infection and for evaluating the ability of compounds to inhibit HIV infection. Compounds inhibiting HIV infection include compounds targeting identified proteins and compounds targeting nucleic acids encoding the proteins.

2011006, Mar 17, 2011

Oct 20, 2008

12/739186

Amy S. Espeseth - Chalfont PA, US
Daria J. Hazuda - Doylestown PA, US
Min Xu - Ambler PA, US
Honglin Zhou - North Wales PA, US

C12Q 1/70
C07H 21/00
C12Q 1/68

435 5, 536 245, 435 6

A set of cellular genes that were identified by siRNA screening as being essential for Human Immunodeficiency Virus (HIV) infection. These genes are host cellular factors involved in DNA repair, specifically in the base excision repair pathway.

2013011, May 9, 2013

Jul 13, 2011

13/809475

Renee C. Gaspar - Souderton PA, US
Paul J. Shughrue - West Chester PA, US
Fubao Wang - Dresher PA, US
Weirong Wang - Harleysville PA, US
Ningyan Zhang - Ambler PA, US
Wei-Qin Zhao - North Wales PA, US
Min Xu - Ambler PA, US
Alexander McCampbell - Chalfont PA, US

C07K 16/18

4241721, 5303891, 5303882, 435375, 435 71, 506 9, 435 792

Disclosed are antibodies that bind amyloid beta-derived diffusible ligands, also known as ADDLs. The antibodies are selective for ADDLs, can penetrate the brain, and are useful in methods of detecting ADDLs and diagnosing Alzheimer's disease. The antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with ADDLs.

2018014, May 31, 2018

Nov 26, 2016

15/361382

Wenhua Li - Auburndale MA, US
Min Xu - Auburndale MA, US

G01S 7/02
G01S 13/02
G01S 13/93
G01S 17/93

This invention is related to a cognitive Multi-Input Multi-Output (MIMO) radio frequency (or laser) radar with large-area synchronized multi-dimensional hopping spread spectrum and Interference-Free Windows (IFWs) for autonomous vehicles comprising of (1) analog component; (2) digital baseband component; (3) multi-dimensional hopping code generator; (4) large-area time synchronization; (5) cooperative IFW; and (6) cognitive engine. The new MIMO radar can provide interference-free environmental perception intelligently by the multi-dimensional IFWs formulated by beat-frequency hopping, beat-time hopping, discrete sequence (DS), cooperative IFW, array processing, and image denoising and fusion, etc. This invention increases the frequency efficiency greatly, and be applied to autonomous vehicles and robotics under sparse, dense, mixed autonomous and human driving, or completely autonomous driving environments.

2016023, Aug 11, 2016

Dec 21, 2015

14/976373

Wenhua Li - Auburndale MA, US
Min Xu - Auburndale MA, US

H04L 9/00
H04L 29/08

A post-quantum physical-layer encryption/decryption system based on chaotic Baseband Modulation Hopping (BMH). The baseband constellation, mapping, power level, and phase will vary symbol-by-symbol according to assigned random sequences. Pre-shared secret keys are used as the chaotic system parameters, initialization, and quantization parameters to generate the BMH codes. The BMH physical-layer encryption/decryption system can be combined with digital-domain based encryption algorithms such as AES, code-based post-quantum cryptography, and other physical-layer secure communication techniques such as Frequency Hopping (FH) and Direct Sequence Spread Spectrum (DSSS). It can also be combined with Quantum Key Distribution (QKD) to provide mutual authenticated key distribution. This invention can be applied to all kinds of communication systems including wireless (radio frequency, optical, quantum channel, sonar) and wire (optical fiber, power-line, telephone line, wire quantum channel, etc.), single carrier and multi-carrier, OFDM, MIMO channels.

2016022, Aug 4, 2016

Dec 19, 2015

14/975755

Wenhua Li - Auburndale MA, US
Min Xu - Auburndale MA, US

G01S 7/02
G01S 13/00

This invention is related to a deep multi-sensor fusion system for inter-radar interference-free environmental perception comprising of (1) polystatic Multi-Input Multi-Output (MIMO) radars such as radio frequency radar and laser radar; (2) vehicle self-localization and navigation; (3) the Internet of Vehicles (IoV) including Vehicle-to-Vehicle communication (V2V), Vehicle-to-Infrastructure communication (V2I), other communication systems, data center/cloud; (4) passive sensors such as EOIR, and (5) deep multi-sensor fusion algorithms. The self-localization sensors and V2X formulate cooperative sensors. The polystatic MIMO radar on each vehicle utilizes both its own transmitted radar signals and ones from other vehicles to detect obstacles. The transmitted radar signals from other vehicles are not considered as interference or uselessness as conventional radars, but considered as useful signals to formulate a polystatic MIMO radar which can overcome the interference problem and improve the radar performance. This invention can be applied to all kinds of vehicles and robotics.