Inventors:
- Charlottesville VA, US
Robert M. Carey - Charlottesville VA, US
John E. Jones - Gaithersburg MD, US
Pedro A. Jose - Lorton VA, US
Scott M. Williams - Hanover NH, US
Assignee:
University of Virginia Patent Foundation - Charlottesville VA
International Classification:
C12Q 1/68
A23L 1/29
US Classification:
514173, 435 611, 506 7, 506 9, 506 16, 506 13, 514249, 5142232, 51425506, 5142362, 51425217, 514307, 51421207, 514381, 514356, 514567, 514462, 514248
Abstract:
It was determined whether SNPs in SLC4A5 are associated with salt sensitivity of blood pressure (BP). Subjects consumed an isocaloric constant diet with a randomized order of 7 days low Na (10 mmol/d) and 7 days high Na (300 mmol/d) intake. Salt sensitivity was defined as a ≧7 mm Hg increase in mean arterial pressure (MAP). 35 polymorphisms in 17 candidate genes were assayed. Association analyses with salt sensitivity revealed three variants that associated with salt sensitivity, two in SLC4A5 (rs7571842, rs10177833; P