Inventors:
Nader Fotouhi - Chatham NJ
Paul Gillespie - Westfield NJ
Robert William Guthrie - Saddle Brook NJ
Weiya Yun - Warren NJ
Assignee:
Hoffman-La Roche Inc. - Nutley NJ
International Classification:
C07C23584
US Classification:
544133, 548251, 548187, 5483381, 548180, 548125, 548127, 5483751, 548261, 548495, 546175, 546247, 546337, 544236, 544367, 544311, 562444, 549441, 549493, 549126, 549 58
Abstract:
Aromatic dehydroamino acids are disclosed that are active as LFA-1 arnagonists This activity enables these compounds to prevent inflammation which is a consequence of T cell activation and accordingly reduce or eliminate inflammatory skin disease psoriasis.