Nicholas J Cotton, 5718 Wayside Rd, Westboro, MA 01581

7789841, Sep 7, 2010

Apr 24, 2002

10/131784

James William Huckle - Northallerton, GB
Andrew J. Carter - Acton MA, US
Nicholas J. Cotton - Westboro MA, US
William R. Walsh - Maroubra, AU
Nelson Scarborough - Andover MA, US
Roger Talish - Hillsborough NJ, US

Exogen, Inc. - Piscataway NJ

A61H 1/00
A61H 1/02
A61H 5/00

601 2

The invention relates to methods and apparatus for therapeutically treating connective tissue or increasing vascularization in tissue using ultrasound. More particularly, the present invention relates to methods and apparatus which use ultrasound to stimulate growth or healing, or to treating pathologies, of connective tissue, or to increase vascularization in ischaemic or grafted tissue using ultrasound.

8529625, Sep 10, 2013

Aug 22, 2003

10/645962

David Farrar - York, GB
Malcolm Brown - Otley, GB
Michael Hall - Middlesbrough, GB
John Eric Brunelle - Boston MA, US
Nicholas John Cotton - Westborough MA, US
Rod Berube - North Attleboro MA, US
John Lipchitz - Watertown MA, US

Smith & Nephew, Inc. - Andover MA

A61F 2/28

623 1611, 623 2375

Tissue fixation devices are provided. The devices include a first component and a second component, the components having different rates of in vivo degradation. The first component and second component are arranged so that, upon degradation of one of the components, the other component provides a scaffold into which bone can grow.

8545866, Oct 1, 2013

Jul 30, 2010

12/847511

Nicholas John Cotton - Westborough MA, US
Melissa Jane Egan - Plympton MA, US

Smith & Nephew, Inc. - Andover MA

A61F 2/00

424423

Described herein are biocompatible compositions that contain a copolymer and a filler material. In particular, described herein are compositions that include a copolymer and a filler which may be a calcium salt. Also described herein are methods in which the compositions are used to attach soft tissue to bone.

2006012, Jun 8, 2006

Oct 28, 2005

11/262336

Nicholas Cotton - Westborough MA, US
John Brunelle - Huntington Beach CA, US

A61K 31/765
A61K 33/10

424078370, 424687000

The present invention is based, in part, on studies we conducted with biocompatible compositions that contain a copolymer and a filler material. Accordingly, the invention features compositions that include a copolymer (e.g., a copolymer that includes lactic acid and/or glycolic acid monomers) and a filler such as calcium carbonate (e.g., about 30-40% CaCOby weight (i.e., by weight of the composition as a whole)).

2007012, Jun 7, 2007

Jan 30, 2007

11/668497

David Farrar - York, GB
Malcolm Brown - Otley, GB
Michael Hall - Linthrope, GB
John Brunelle - Boston MA, US
Nicholas Cotton - Westborough MA, US
Rod Berube - North Attleboro MA, US
John Lipchitz - Lawrence MA, US

Smith & Nephew, Inc. - Andover MA

A61F 2/02

623023720, 623023750

Tissue fixation devices are provided. The devices include a first component and a second component, the components having different rates of in vivo degradation. The first component and second component are arranged so that, upon degradation of one of the components, the other component provides a scaffold into which bone can grow.

2008023, Sep 25, 2008

Mar 21, 2008

12/053264

Nicholas Cotton - Westborough MA, US
Rebecca A. Blough - Cumberland RI, US
Melissa J. Egan - Plympton MA, US
Horacio Montes de Oca Balderas - York, GB
Malcolm Brown - Otley, GB
Michael Hall - Linthrope, GB

Smith & Nephew, Inc. - Andover MA

A61B 17/04
A61B 17/56

606232, 606304

In one aspect, the present disclosure relates to a surgical device including an anchor body having an opening, the anchor body having a copolymer composition including polylactide-co-glycolide and calcium carbonate, wherein the calcium carbonate comprises more than 30% but less than 40% of the weight of the composition; and a flexible member passing through the opening, wherein deformation of the device occurs at body temperature. The present disclosure also relates to an oriented polymer material having a copolymer composition including a polylactide-co-glycolide and calcium carbonate, the calcium carbonate comprising more than 30% but less than 40% of the weight of the composition, wherein the material changes shape upon introduction to an environment having a temperature that is lower than a relaxation temperature of the material. A method of repairing soft tissue and other surgical devices are also disclosed.

2008028, Nov 20, 2008

May 12, 2008

12/119045

Nicholas Cotton - Westborough MA, US
Catherine Booth - Hingham, GB
James Huckle - West Rounton, GB
Graeme Howling - Roundhay, GB

Smith & Nephew, Inc. - Andover MA

A61F 2/04
A61K 33/06
A61P 19/08
A61K 33/10

424426, 424682, 424687, 424423

The disclosure relates to medical devices capable of enhancing ossification in a subject. More specifically, the disclosure relates to the use of devices comprising a releasable calcium sensing receptor agonist and a releasable calcium salt.

2010004, Feb 18, 2010

Jun 15, 2009

12/484274

Nicholas J. Cotton - Westborough MA, US
Emma J. Wright - Arlington MA, US
Steven W. Astorino - Norton MA, US
Saad Ali - York, GB

A61K 9/00
A61K 47/32
A61K 31/19
A61K 31/225
A61K 38/02
A61K 38/16
A61K 38/14
A61K 38/45
A61K 38/48
A61K 31/727
A61K 31/728
A61K 31/44
A61P 19/04

424423, 5147724, 514557, 514547, 514 2, 514 12, 514 8, 424 945, 424 9464, 514 56, 514 54, 514355

Fixation devices for tissue repair, for example sutures, surgical arrows, staples, darts, bolts, screws, buttons, anchors, nails, rivets, or barbed devices comprise at least one of angiogenic material; angiogenic precursor material which is capable of breaking down in vivo to form angiogenic material; or tissue-engineered material, which tissue-engineered material is capable of producing angiogenic material. In a preferred form, the material is incorporated into a polymer matrix having predetermined hydrophobicity to allow controlled release of angiogenic materials such as butyric or hydroxybutyric acid or salts thereof. Polymer matrix compositions comprising angiogenic materials and methods for tissue repair are also provided.