Nicole June Parrish, 5437 Horseman Ct, Mcdonogh Run, MD 21133

7385086, Jun 10, 2008

Jan 27, 2004

10/764451

Craig A. Townsend - Baltimore MD, US
James D. Dick - Upperco MD, US
Gary R. Pasternack - Baltimore MD, US
Francis P. Kuhajda - Lutherville MD, US
Nicole M. Parrish - Ellicott City MD, US

The Johns Hopkins University School of Medicine - Baltimore MD

C07C 317/00
C07C 317/02
C07C 317/04
C07C 317/06
C07C 317/08

568 27, 568 28, 568 31, 514550, 514618

This invention provides compounds and methods for treating, with said compound, a mycobacterial infection by administering to an animal a pharmaceutical composition containing a compound having the formula R—SO-Z-CO—Y, where R is an alkyl groups having 6-20 carbon atoms, unsaturated hydrocarbon groups having 6-20 carbon atoms, or alkyl groups having 6-20 carbon atoms interrupted by at least one aromatic ring; Z is —CH—, —CHCH—, —NH—NH—, —O—, ——NH—, —O—NH—, —CH—NH—, —CH—O—, —NH—O—, —NH—CH—, —O—CH—, and —CH═CH—; Y is —NH, —O—CH—CH, —CO—CO—O—CH, and —O—CH; and n is 1 or 2. It has been discovered that these compounds treat microbially-based infections caused by corynebacteria, nocardiae, rhodococcus, and mycobacteria. These compounds may be used to treat mycobacterial cells, such as , drug resistant , and pathogenic sp.

2006013, Jun 22, 2006

Jul 9, 2003

10/520506

Craig Townsend - Baltimore MD, US
James Dick - Baltimore MD, US
Nicole Parrish - Ellicott City MD, US
Minerva Hughes - Baltimore MD, US

A61K 31/455
A61K 31/421
A61K 31/381
A61K 31/365
A61K 31/16
A61K 31/22

514355000, 514374000, 514445000, 514471000, 514550000, 514614000

A method of treating a subject with a microbially-based infection, comprising the administration of a compound to the subject. The compound is able to decrease ATP levels in the microbe by at least 10% compared to controls after 24 hours in an in vitro test, without killing mammalian cells during the same time period. The decrease in ATP levels is measured by: (1) removing the cells from the testing location and putting them on ice; (2) harvesting the cells at 4 degrees C. by centrifugation and disrupting it with bead-beating in an ATP extraction buffer; (3) removing cellular debris by centrifugation at 4 degrees C., leaving an ATP-containing supernatant; (4) measuring the amount of ATP present in the supernatant by a bioluminescence assay at 4 degrees C.

2007024, Oct 18, 2007

Feb 8, 2007

11/672909

Nicole Parrish - Ellicott City MD, US
Albert Owens - Bel Air MD, US
James Dick - Upperco MD, US

FASgen Inc. - Baltimore MD

A61K 31/165
C07C 233/05
C12N 1/20
C12N 1/38

514625000, 435243000, 435253100, 564192000

The invention provides anti-microbial compositions, including compositions with inhibitory activity against mycobacteria. The invention further provides methods for treating microbial infections, including the treatment of mycobacterial infection and diseases such as tuberculosis.

6713654, Mar 30, 2004

Aug 28, 2000

09/486550

Craig A. Townsend - Baltimore MD
James D. Dick - Upperco MD
Gary R. Pasternack - Baltimore MD
Francis P. Kuhajda - Lutherville MD
Nicole M. Parrish - Ellicott City MD

The Johns Hopkins University School of Medicine - Baltimore MD

C07C31500

568 27, 568 28, 568 31

This invention provides methods for treating a mycobacterial infection by administering to an animal a pharmaceutical composition containing a compound having the formula RâSO âZâCOâY, where R is an alkyl group having 6-20 carbons; Z is a radical selected from âCH â, âOâ, and âNHâ, two of these radicals coupled together, or âCH CH â; Y is âNH , OâCH âC H , âCOâCOâOâCH , or OâCH ; and n is 1 or 2. It has been discovered that these compounds inhibit growth of microbial cells which synthesize -substitued, -hydroxy fatty acids, particularly corynemycolic acid, nocardic acid, and mycolic acid. These compounds may be used to inhibit growth of mycobacterial cells, such as drug-resistant and.