Niels Anderson resumes & CV records
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Niels Anderson
Niels Anderson
Niels H Anderson DeceasedSeattle, WA
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Seattle, WA
Mendocino, CA
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Us Patents
Pharmaceutical Composition Containing Prostadienoic Acid For Regulating Gastric Secretion
US Patent:
4115545, Sep 19, 1978
Filed:
Aug 11, 1977
Appl. No.:
5/823811
Inventors:
Ned M. Weinshenker - Sunnyvale CA
Niels H. Anderson - Seattle WA
Niels H. Anderson - Seattle WA
Assignee:
Alza Corporation - Palo Alto CA
International Classification:
A61K 3122
A61K 3119
A61L 904
A61K 3119
A61L 904
US Classification:
424 45
Abstract:
Novel alkyl diethers of prostaglandins of the formula; ##STR1## wherein R. sub. 1 is hydrogen or lower alkyl; R. sub. 2 and R. sub. 6 are hydrogen when Y is a single bond and R. sub. 2 and R. sub. 6 are absent when Y is a double bond; R. sub. 3 is keto, ##STR2## R'. sub. 9 is hydrogen or lower alkyl; R'. sub. 10 is lower alkyl; R'. sub. 11 is lower alkyl; Z. sub. 1 is cis or trans --CH. dbd. CH-- or --CH. sub. 2 CH. sub. 2 --; Z. sub. 2 is trans --CH. dbd. CH-- or --CH. sub. 2 CH. sub. 2 --; X is a single bond or a double bond and X is a single bond when R. sub. 4 and R. sub. 5 are hydrogen; Y is a single bond or a double bond; n is 1 to 5, m is 0 to 4; and the non-toxic salts. The prostaglandin ethers possess valuable pharmacological properties as modifiers of smooth muscle activity, gastric secretion, blood pressure, lipolysis and the reproductive system. The compounds also induce labor and menses and they can be used for the relief of asthma and nasal congestion. The compounds are also useful as platelet anti-clumping agents and for the inhibition of peptic ulcers.
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