Norman R Wainwright, 73414 Longpoint On Owasco, Auburn, NY 13021
Norman Wainwright Phones & Addresses
Skaneateles, NY
Auburn, NY
Cato, NY
Kiawah Island, SC
Salt Lake City, UT
Falmouth, MA
Charleston, SC
44 Cotton Hall, Kiawah Island, SC 29455
Work
Position:
Professional/Technical
Education
Degree:
Graduate or professional degree
Mentions for Norman R Wainwright
Publications & IP owners
Wikipedia
Norman Wainwright
Norman Wainwright (4 July 1914 2 May 2000) was an English freestyle and backstroke swimmer who competed for Great Britain in the 1932 Summer Olympics, in the 1936 Summer Olympics ...
Us Patents
Methods And Compositions For The Detection Of Bacterial Endotoxins
US Patent:
6391570, May 21, 2002
Filed:
Sep 18, 2000
Appl. No.:
09/665221
Inventors:
Foster T. Jordan - Hollywood SC
Hui-Ti Chiang - Charleston SC
James F. Cooper - Charleston SC
Norman R. Wainwright - Falmouth MA
Hui-Ti Chiang - Charleston SC
James F. Cooper - Charleston SC
Norman R. Wainwright - Falmouth MA
Assignee:
Charles River Laboratories - Wilmington MA
International Classification:
G01N 33554
US Classification:
435 732, 4241841, 4242341, 4242781, 4242821, 435 4, 435 72, 435 34, 435184, 435962, 514 23
Abstract:
The invention provides methods and compositions for the detection and/or quantification of bacterial endotoxins. In particular, provided herein is an inexpensive and reproducible method for producing an improved amebocyte lysate preparation having reduced Factor G activity. Provided also is an endotoxin-specific amebocyte lysate preparation produced by such a method. In addition, the invention provides methods and compositions akin for enhancing the sensitivity to endotoxins of amebocyte lysate preparations having reducing Factor G activity. In particular, the sensitivity of such amebocyte lysate preparations to endotoxins can be enhanced by the addition of exogenous (1â3) -D-glucan.
Method For Classifying A Microorganism In A Biological Sample
US Patent:
7901899, Mar 8, 2011
Filed:
Oct 23, 2008
Appl. No.:
12/257030
Inventors:
Norman R. Wainwright - Johns Island SC, US
Dana M. Nutter - Charleston SC, US
Dana M. Nutter - Charleston SC, US
Assignee:
Charles River Laboratories, Inc. - Wilmington MA
International Classification:
G01N 33/53
US Classification:
435 72
Abstract:
The invention provides a method using a hemocyte preparation, for example, amebocyte lysate, for detecting in a single assay the presence of at least one of a Gram negative bacterium, a Gram positive bacterium, and a fungus in a sample of interest. The method exploits the differential reactivity of Gram negative bacteria, Gram positive bacteria, and fungi with the hemocyte preparation to produce measurable changes in a property, for example, an optical property, of the mixture. Because the Gram negative bacteria, Gram positive bacteria and fungi each produce different changes in a given property, for example, an optical property, it is possible to classify the type of microorganism present in the sample of interest.
Methods For The Detection Of Microbial Contaminants
US Patent:
7939291, May 10, 2011
Filed:
Aug 1, 2007
Appl. No.:
11/832261
Inventors:
Norman R. Wainwright - Johns Island SC, US
Foster T. Jordan - Chapin SC, US
Foster T. Jordan - Chapin SC, US
Assignee:
Charles River Laboratories, Inc. - Wilmington MA
International Classification:
G01N 33/569
G01N 33/579
G01N 33/577
G01N 33/579
G01N 33/577
US Classification:
435 34, 435 72, 435 23, 435 24, 435 791, 435 792
Abstract:
The invention provides methods and compositions for the detection and/or quantification of a microbial contaminant, for example, a bacterial endotoxin or a glucan, in a sample. In particular, the invention provides a test cartridge useful in the practice of hemocyte lysate-based assays for the detection and/or quantification of a microbial contaminant in a sample. In addition, the invention provides methods of making and using such cartridges. In addition, the invention provides a rapid, sensitive, multi-step kinetic hemocyte lysate-based assay for the detection and/or quantification of a microbial contaminant in a sample. In addition, the invention provides a glucan-specific lysate that can be used in a variety of assay formats, including, for example, a test cartridge, optionally configured to perform a kinetic assay.
Methods For The Detection And/Or Quantification Of Gram Positive Bacterial Contaminants
US Patent:
7968280, Jun 28, 2011
Filed:
Dec 1, 2005
Appl. No.:
11/292295
Inventors:
Norman R. Wainwright - Johns Island SC, US
Foster T. Jordan - Chapin SC, US
Foster T. Jordan - Chapin SC, US
Assignee:
Charles River Laboratories, Inc. - Wilmington MA
International Classification:
C12Q 1/00
A61K 35/56
A61K 35/56
US Classification:
435 4, 424538
Abstract:
The invention provides methods and compositions for the detection and/or quantification of a Gram positive bacterial contaminant in a sample. In particular, the invention provides hemocyte-based preparations, methods of making such hemocyte-based preparations, and methods of using such hemocyte-based preparations for the detection and/or quantification of the Gram positive bacterial contaminant.
Methods For The Detection And/Or Quantification Of Gram Positive Bacterial Contaminants
US Patent:
8440394, May 14, 2013
Filed:
Apr 11, 2011
Appl. No.:
13/083996
Inventors:
Norman R. Wainwright - Johns Island SC, US
Foster T. Jordan - Chapin SC, US
Foster T. Jordan - Chapin SC, US
Assignee:
Charles River Laboratories, Inc. - Wilmington MA
International Classification:
C12Q 1/00
C12Q 1/02
C12Q 1/04
C12Q 1/02
C12Q 1/04
US Classification:
435 4, 435 29, 435 34
Abstract:
The invention provides methods and compositions for the detection and/or quantification of a Gram positive bacterial contaminant in a sample. In particular, the invention provides hemocyte-based preparations, methods of making such hemocyte-based preparations, and methods of using such hemocyte-based preparations for the detection and/or quantification of the Gram positive bacterial contaminant.
Methods And Compositions For The Detection Of Bacterial Endotoxins
US Patent:
2003010, Jun 5, 2003
Filed:
Apr 26, 2002
Appl. No.:
10/133212
Inventors:
Foster Jordan - Hollywood SC, US
Hui-Ti Chiang - Charleston SC, US
James Cooper - Charleston SC, US
Norman Wainwright - Falmouth MA, US
Hui-Ti Chiang - Charleston SC, US
James Cooper - Charleston SC, US
Norman Wainwright - Falmouth MA, US
Assignee:
Charles River Laboratories - Wilmington MA
International Classification:
G01N033/554
G01N033/569
C12P021/06
C07K016/12
G01N033/569
C12P021/06
C07K016/12
US Classification:
435/007320, 435/068100, 530/387100
Abstract:
The invention provides methods and compositions for the detection and/or quantification of bacterial endotoxins. In particular, provided herein is an inexpensive and reproducible method for producing an improved amebocyte lysate preparation having reduced Factor G activity. Provided also is an endotoxin-specific amebocyte lysate preparation produced by such a method. In addition, the invention provides methods and compositions for enhancing the sensitivity to endotoxins of amebocyte lysate preparations having reducing Factor G activity. In particular, the sensitivity of such amebocyte lysate preparations to endotoxins can be enhanced by the addition of exogenous (1→3) -D-glucan.
Cartridge And Method For Sample Analysis
US Patent:
2009028, Nov 19, 2009
Filed:
Apr 15, 2009
Appl. No.:
12/424190
Inventors:
Norman R. Wainwright - Johns Island SC, US
Andrew Steele - Takoma Park MD, US
Andrew Steele - Takoma Park MD, US
International Classification:
C40B 30/04
C40B 60/12
C40B 60/12
US Classification:
506 9, 506 39
Abstract:
The invention provides a cartridge containing an addressable array for detecting the presence of one or more target analytes in a fluid sample. The cartridge comprises (i) a housing defining a sample inlet, an optical cell, an outlet, a first conduit in fluidic communication with the sample inlet and the optical cell, and a second conduit in fluidic communication with the outlet and the optical cell, (ii) an addressable array disposed within the optical cell; and (iii) a reagent dried upon a fluid contacting surface of at least one of the sample inlet and the first conduit, such that, when a fluid sample is applied to the fluid inlet, the fluid sample mobilizes and transports the reagent to the optical cell. The invention also provides a method of detecting one or more analytes in a fluid sample of interest.
Compositions For The Detection Of Microbial Contaminants
US Patent:
2011020, Aug 18, 2011
Filed:
Apr 27, 2011
Appl. No.:
13/095390
Inventors:
Norman R. Wainwright - Johns Island SC, US
Foster T. Jordan - Chapin SC, US
Foster T. Jordan - Chapin SC, US
Assignee:
Charles River Laboratories, Inc. - Wilmington MA
International Classification:
C12Q 1/04
US Classification:
435 34
Abstract:
The invention provides methods and compositions for the detection and/or quantification of a microbial contaminant, for example, a bacterial endotoxin or a glucan, in a sample. In particular, the invention provides a test cartridge useful in the practice of hemocyte lysate-based assays for the detection and/or quantification of a microbial contaminant in a sample. In addition, the invention provides methods of making and using such cartridges. In addition, the invention provides a rapid, sensitive, multi-step kinetic hemocyte lysate-based assay for the detection and/or quantification of a microbial contaminant in a sample. In addition, the invention provides a glucan-specific lysate that can be used in a variety of assay formats, including, for example, a test cartridge, optionally configured to perform a kinetic assay.
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