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Pablo M Leon, 653922 Clay St, San Francisco, CA 94118

Pablo Leon Phones & Addresses

3922 Clay St, San Francisco, CA 94118   

1270 33Rd Ave, San Francisco, CA 94122   

Chicago, IL   

Philadelphia, PA   

Mentions for Pablo M Leon

Career records & work history

Medicine Doctors

Pablo Leon

Specialties:
Plastic Surgery
Work:
UCSF Medical Center Plastic & Reconstructive Surgery
350 Parnassus Ave STE 509, San Francisco, CA 94117
415-4763061 (phone) 415-3534622 (fax)
Education:
Medical School
University of Chicago Pritzker School of Medicine
Graduated: 1986
Procedures:
Arthrocentesis, Breast Reconstruction, Hernia Repair
Conditions:
Breast Disorders, Melanoma, Overweight and Obesity, Skin Cancer, Varicose Veins, Ventral Hernia
Languages:
English
Description:
Dr. Leon graduated from the University of Chicago Pritzker School of Medicine in 1986. He works in San Francisco, CA and specializes in Plastic Surgery. Dr. Leon is affiliated with San Francisco General Hospital Medical Center and UCSF Medical Center Mount Zion.
Pablo Leon Photo 1

Pablo Leon, San Francisco CA

Specialties:
Plastic Surgery
Surgery
Work:
UCSF Medical Center / Moffitt-Long Hospitals
350 Parnassus Ave, San Francisco, CA 94117San Francisco Veterans Affairs Medical Center
4150 Clement St, San Francisco, CA 94121
Education:
University of Chicago (1986)
Pablo Leon Photo 2

Pablo Leon, San Francisco CA

Specialties:
Plastic Surgeon
Address:
350 Parnassus Ave, San Francisco, CA 94117
Education:
University of Chicago, Pritzker School of Medicine - Doctor of Medicine
UCSF Medical Center - Residency - Plastic Surgery
Bernard Mitchell Hospital-University of Chicago Hospitals - Residency - Surgery
Board certifications:
American Board of Plastic Surgery Certification in Plastic Surgery

License Records

Pablo Leon

Address:
Philadelphia, PA 19130
Licenses:
License #: MD044861E - Expired
Category: Medicine
Type: Medical Physician and Surgeon

Publications & IP owners

Us Patents

2-[1-Phenyl-5-Hydroxy-4A-Substituted-Hexahydrocyclopenta[F]Indazol-5-Yl]Ethyl Phenyl Derivatives As Glucocorticoid Receptor Ligands

US Patent:
2012021, Aug 23, 2012
Filed:
Oct 26, 2010
Appl. No.:
13/504260
Inventors:
Christopher James Bungard - Lansdale PA, US
James J. Perkins - Churchville PA, US
Jesse J. Manikowski - Norristown PA, US
Pablo de Leon - Philadelphia PA, US
Robert S. Meissner - Schwenksville PA, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
A61K 31/4439
C07D 401/10
C07D 231/54
A61P 41/00
A61P 35/02
A61P 37/00
A61P 3/10
A61P 3/04
A61P 3/00
A61P 1/00
A61P 19/02
A61P 37/08
A61P 11/00
A61P 11/06
A61P 21/00
A61P 31/14
A61P 29/00
A61P 17/06
A61P 17/00
A61P 17/10
A61P 31/18
A61P 35/00
A61P 25/00
A61P 25/24
A61P 25/18
A61P 25/20
A61P 25/22
C07D 401/04
A61K 31/416
US Classification:
514338, 514406, 5462757, 5483565
Abstract:
The present invention encompasses compounds of Formula I: or pharmaceutically acceptable salts or hydrates thereof, which are useful as selective glucocorticoid receptor ligands for treating a variety of autoimmune and inflammatory diseases or conditions. Pharmaceutical compositions and methods of use are also included.

Quinolinone Pde2 Inhibitors

US Patent:
2012011, May 10, 2012
Filed:
Jul 19, 2010
Appl. No.:
13/384946
Inventors:
Pablo De Leon - Philadelphia PA, US
Melissa Egbertson - Ambler PA, US
Ivory D. Hills - Harleysville PA, US
Adam Wayne Johnson - North Wales PA, US
Michelle Machacek - Brookline MA, US
International Classification:
A61K 31/4709
C07D 409/04
C07D 215/22
A61K 31/4704
A61P 25/18
C07D 401/12
A61P 25/22
A61P 25/00
A61P 25/16
C07D 409/14
A61K 31/506
US Classification:
514256, 546157, 514312, 544333
Abstract:
The present invention is directed to quinolinone compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

Quinoline Carboxamide And Quinoline Carbonitrile Derivatives As Mglur2-Negative Allosteric Modulators, Compositions, And Their Use

US Patent:
2016015, Jun 9, 2016
Filed:
Feb 18, 2016
Appl. No.:
15/047224
Inventors:
- Rahway NJ, US
Antonella Converso - Elkins Park PA, US
Pablo De Leon - Philadelphia PA, US
Barbara Hanney - Pennsburg PA, US
Timothy John Hartingh - Blue Bell PA, US
Jesse Josef Manikowski - Worcester PA, US
Peter J. Manley - Harleysville PA, US
Robert Meissner - Newton MA, US
Zhaoyang Meng - Lansdale PA, US
James J. Perkins - Churchville PA, US
Michael T. Rudd - Collegeville PA, US
Youheng Shu - Blue Bell PA, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
A61K 31/47
A61K 31/541
A61K 31/506
A61K 31/496
A61K 31/4985
A61K 31/4709
A61K 31/5377
Abstract:
The present invention provides quinoline carboxamide and quinoline carbonitrile compounds of formula (I)

Quinoline Carboxamide And Quinoline Carbonitrile Derivatives As Mglur2-Negative Allosteric Modulators, Compositions, And Their Use

US Patent:
2016015, Jun 9, 2016
Filed:
Feb 18, 2016
Appl. No.:
15/047213
Inventors:
- Rahway NJ, US
Antonella Converso - Elkins Park PA, US
Pablo De Leon - Philadelphia PA, US
Barbara Hanney - Pennsburg PA, US
Timothy John Hartingh - Blue Bell PA, US
Jesse Josef Manikowski - Worcester PA, US
Peter J. Manley - Harleysville PA, US
Robert Meissner - Newton MA, US
Zhaoyang Meng - Lansdale PA, US
James J. Perkins - Churchville PA, US
Michael T. Rudd - Collegeville PA, US
Youheng Shu - Blue Bell PA, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C07D 215/48
C07D 409/04
C07D 401/06
C07D 417/14
C07D 417/06
C07D 401/14
C07D 471/04
C07D 401/04
C07D 413/06
Abstract:
The present invention provides quinoline carboxamide and quinoline carbonitrile compounds of formula (I)

Quinoline Carboxamide And Quinoline Carbonitrile Derivatives As Mglur2-Negative Allosteric Modulators, Compositions, And Their Use

US Patent:
2014030, Oct 16, 2014
Filed:
Oct 26, 2012
Appl. No.:
14/356080
Inventors:
- Rahway NJ, US
Antonella Converso - Elkins Park PA, US
Pablo De Leon - Philadelphia PA, US
Barbara Hanney - Pennsburg PA, US
Timothy John Hartingh - Blue Bell PA, US
Jesse Josef Manikowski - Worcester PA, US
Peter J. Manley - Harleysville PA, US
Robert Meissner - Devon PA, US
Zhaoyang Meng - Lansdale PA, US
James J. Perkins - Chruchville PA, US
Michael T. Rudd - Collegeville PA, US
Youheng Shu - Blue Bell PA, US
International Classification:
C07D 413/14
C07D 401/14
C07D 401/06
C07D 401/04
US Classification:
5142365, 51425306, 514256, 514278, 514314, 544128, 544333, 544363, 546 16, 546169
Abstract:
The present invention provides quinoline carboxamide and quinoline carbonitrile compounds of formula (I) wherein ring A, R, -L-, R, n, R, and Rare as defined herein. The compounds of the invention are useful as non-competitive mGluR2 antagonists, or mGluR2 negative allosteric modulators (NAMs), and in methods of treating a patient (preferably a human) for diseases or disorders in which the mGluR2-NAM receptor is involved, such as Alzheimer's disease, cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders, by administering to the patient a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof. The invention is also directed to pharmaceutical compositions comprising a compound of the invention, or a pharmaceutically acceptable salt thereof, (optionally in combination with one or more additional active ingredients), and a pharmaceutically acceptable carrier, and the use of the compounds and pharmaceutical compositions of the invention in the treatment of such diseases.

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