Pak Yin Wong, 76298 Alhambra Ave, Monterey Park, CA 91755

8232095, Jul 31, 2012

Nov 18, 2005

11/719749

Chih-Ming Ho - Brentwood CA, US
Pak Kin Wong - Tucson AZ, US
Ren Sun - Pacific Palisades CA, US
Fuqu Yu - San Diego CA, US

The Regents of the University of California - Oakland CA

C12M 1/00
G05B 19/42

4352891, 700 89

The invention provides systems and methods for manipulating, e. g. , optimizing and controlling, biological systems, e. g. , for eliciting a more desired biological response of biological sample, such as a tissue, organ, and/or a cell. In one aspect, systems and methods of the invention operate by efficiently searching through a large parametric space of stimuli and system parameters to manipulate, control, and optimize the response of biological samples sustained in the system, e. g. , a bioreactor. In alternative aspects, systems include a device for sustaining cells or tissue samples, one or more actuators for stimulating the samples via biochemical, electromagnetic, thermal, mechanical, and/or optical stimulation, one or more sensors for measuring a biological response signal of the samples resulting from the stimulation of the sample. In one aspect, the systems and methods of the invention use at least one optimization algorithm to modify the actuator's control inputs for stimulation, responsive to the sensor's output of response signals. The compositions and methods of the invention can be used, e. g.

2013013, May 23, 2013

Jul 30, 2012

13/562216

Chih-Ming HO - Brentwood CA, US
Pak Kin WONG - Tuscon AZ, US
Ren SUN - Pacific Palisades CA, US
Fuqu YU - San Diego CA, US

Regents of the University of California - Oakland CA

C12Q 1/02

4352861

The invention provides systems and methods for manipulating biological systems, for example to elicit a more desired biological response from a biological sample, such as a tissue, organ, and/or a cell. In one aspect, the invention operates by efficiently searching through a large parametric space of stimuli and system parameters to manipulate, control, and optimize the response of biological samples sustained in the system In one aspect, the systems and methods of the invention use at least one optimization algorithm to modify the actuator's control inputs for stimulation, responsive to the sensor's output of response signals. The invention can be used, e.g., to optimize any biological system, e.g., bioreactors for proteins, and the like, small molecules, polysaccharides, lipids, and the like. Another use of the apparatus and methods includes is for the discovery of key parameters in complex biological systems.