Patrick R Treanor, 70122 Curve St, Dedham, MA 02026

8211628, Jul 3, 2012

Feb 19, 2008

12/527119

Hemant Thatte - Medfield MA, US
Patrick Treanor - Dedham MA, US
Shukri F. Khuri - Needham MA, US
Randa Khuri, legal representative - Needham MA, US
Laki Rousou - New York NY, US

President and Fellows of Harvard College - Cambridge MA
The United States of America as Represented by the Department of Veterans Affairs - Washington DC

A01N 1/00

435 11, 435 12

Methods and compositions for resuscitating, storing, and preserving functional integrity of organs and tissues. Metabolic function is maintained by sustaining ATP levels, mitochondrial function, cardiomyocyte contractility, prevention of acidosis, inhibition of induction of apoptosis, maintaining ionontrophy and lusiotrophy by regulating calcium, sodium, potassium and chloride ions.

2003004, Feb 27, 2003

May 2, 2002

10/137709

Shukri Khuri - Westwood MA, US
Patrick Treanor - Dedham MA, US

E-Monitors, Inc. - Tewksbury MA

A61B005/05

600/345000

The invention relates to the use of pH measurements of tissue as a system for controlling diagnostic and/or surgical procedures. The invention also relates to an apparatus used to perform tissue pH measurements. Real time tissue pH measurements can be used as a method to determine ischemic segments of the tissue and provide the user with courses of conduct during and after a surgical procedure. When ischemia is found to be present in a tissue, a user can effect an optimal delivery of preservation fluids to the site of interest and/or effect a change in the conduct of the procedure to raise the pH of the site. A preferred embodiment includes a method of detecting acidosis in tissue comprising the steps of contacting the tissue of a patient with a first pH electrode disposed in an anterior wall of the left ventricle, and further contacting the tissue of the patient with a second pH electrode disposed in a posterior wall of the left ventricle.

2004013, Jul 15, 2004

Jul 28, 2003

10/628866

Shukri Khuri - Westwood MA, US
Patrick Treanor - Dedham MA, US

E-Monitors, Inc. - Tewksbury MA

A61B005/05

600/345000, 604/065000, 604/066000, 604/067000

While ischemia or tissue acidosis, in cardiac tissue has been measured, systems and methods to prevent and/or reverse tissue, and in particular, cardiac acidosis were unknown. Surgeons did not know how to reverse tissue acidosis once discovered. The present invention relates to systems and/or methods of using tissue pH measurements to diagnose ischemia and to gauge the conduct of an operation, based on these pH measurements, so as to prevent and/or reverse tissue ischemia/acidosis. The current invention provides methods by which tissue acidosis can be corrected once discovered.

2012026, Oct 18, 2012

Jun 5, 2012

13/488749

Hemant Thatte - Medfield MA, US
Patrick Treanor - Dedham MA, US
Shukri F. Khuri - Needham MA, US
Randa Khuri - Needham MA, US
Laki Rousou - New York NY, US

President and Fellows of Harvard College - Cambridge MA
General Counsel-PSG IV (024) - Washington DC

A01N 1/02

435 12, 435 11, 435374

Methods and compositions for resuscitating, storing, and preserving functional integrity of organs and tissues. Metabolic function is maintained by sustaining ATP levels, mitochondrial function, cardiomyocyte contractility, prevention of acidosis, inhibition of induction of apoptosis, maintaining ionontrophy and lusiotrophy by regulating calcium, sodium, potassium and chloride ions.

2012028, Nov 8, 2012

Jul 18, 2012

13/552255

Hemant Thatte - Medfield MA, US
Patrick Treanor - Dedham MA, US
Shukri F. Khuri - Needham MA, US
Randa Khuri - Needham MA, US
Laki Rousou - New York NY, US

United States Government as Represented by the Department of Veterans Affairs - Washington DC
President and Fellows of Harvard College - Cambridge MA

A01N 1/02
C12N 5/071

435 12, 435 11, 435374

Methods and compositions for resuscitating, storing, and preserving functional integrity of organs and tissues. Metabolic function is maintained by sustaining ATP levels, mitochondrial function, cardiomyocyte contractility, prevention of acidosis, inhibition of induction of apoptosis, maintaining ionontrophy and lusiotrophy by regulating calcium, sodium, potassium and chloride ions.

6567679, May 20, 2003

Jun 23, 1999

09/339081

Shukri F. Khuri - Westwood MA
Patrick Treanor - Dedham MA

E-Monitors, Inc. - Tewksbury MA

A61B 500

600345, 604 65, 604 66, 604 67, 126897

The invention relates to the use of pH measurements of tissue as a system for controlling diagnostic and/or surgical procedures. The invention also relates to an apparatus used to perform tissue pH measurements. Tissue pH measurements can be used as a method to determine ischemic segments of the tissue and provide the user with courses of conduct during and after a surgical procedure. When ischemia is found to be present in a tissue, a user can effect an optimal delivery of preservation fluids to the site of interest and/or effect a change in the conduct of the procedure to raise the pH of the site.