Paul Living Bobrowski, 65Rancho Santa Fe, CA

7632524, Dec 15, 2009

Oct 4, 2003

10/679006

Paul J. Bobrowski - Scottsdale AZ, US

A01N 65/00

424725

The invention herein describes an improved and novel means of managing the complications of opioid analgesics, specifically treating the induction of emesis and itch by suppressing the activation of sensory afferent nerves. The composition of the botanical components that provides these benefits do not sacrifice hyperalgesia in order to negate the activity of sensory afferent nerves that drive emesis and itch, but in contrast affords significant analgesic actions in its own right. The combination of a therapeutic approach that negates an increased sensitivity to pain, itch, and nausea is a significant improvement over current treatment options.

2004006, Apr 8, 2004

Sep 30, 2003

10/674986

Paul Bobrowski - Scottsdale AZ, US

C11B001/00

554/008000

The method herein describes a process for the preparation and extraction of components from plants of the family Rubiaceae indigenous to South America, also known as Cat's Claw or U ña de gato. Cat's claw is an ethnomedicine that contains a variety of constituents, some of which have opposing actions. Oxindole and pentacyclic alkaloids have been proposed to be constituents that stimulate immune function, whereas polar constituents act to suppress immune response. An extract that was devoid of the aforementioned alkaloids would avoid opposing actions that may negate effectiveness or limit therapeutic outcome.

2004007, Apr 15, 2004

Oct 3, 2003

10/678817

Paul Bobrowski - Scottsdale AZ, US

A61K033/14
A61K035/78
A61K031/70

424/725000, 514/023000, 424/680000, 424/717000, 514/053000

An improved oral rehydration solution comprising standard formulae of sugars, mineral salts and bicarbonates in combination with Croton species materials with or without the inclusion of material from the Uncaria species. The botanical components are concentrated biologically active materials and thus enhance therapeutic benefit. The Croton component functions as an effective non-paralytic agent in managing diarrhea that is superior to loperamide resulting in a lower stool output. The functionality of the Uncaria species is as an effective anti-inflammatory agent via NF- B activation inhibition and protecting gastrointestinal epithelial cells from oxidant-induced death.

2004013, Jul 15, 2004

Sep 30, 2003

10/676459

Paul Bobrowski - Scottsdale AZ, US

A23K001/00

426/615000

An extract and procedure for extracting the polar components from plants of the Family Brassicaceae, specifically but not limited to the genus Lepidium. The extraction has an increased polar and decreased lipidic constituent concentration with an increased pharmacocological ability to affect growth parameters relative to the parent material. The concentration of polar constituents makes the product more amenable to preparations that increase growth parameters in aquaculture.

2005007, Apr 7, 2005

Oct 4, 2003

10/678990

Paul Bobrowski - Scottsdale AZ, US

A61K035/78

424779000

The invention herein describes an improved approach to managing hemorrhoids by combining current approaches of topical anesthetics, vasoconstrictors, ant-inflammatories, protectants, anti-pruretics, astringents, keratolytics, anticholinergics, cicatrizants, and antimicrobials with species material. The botanical extracts are concentrated biologically active materials and thus provide enhanced therapeutic benefit. The species components add a breadth and immediacy to the termination of neurogenic responses that mediate, sustain, and prolong the symptoms and underlying pathology.