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Kun Liu, 41319 E Wayne St, Maumee, OH 43537

Related to:
Jack Yun Liu 65 Yulin Lin Wang 59 Fei Liu

Kun Liu Phones & Addresses

319 E Wayne St, Maumee, OH 43537   

Bronx, NY   

Work

Company: Albert einstein college of medicine - Bronx, NY 2011 Position: Post-doctoral research fellow

Education

School / High School: University of Toledo College of Medicine- Toledo, OH 2005 Specialities: Ph.D. in Biomedical Science

Skills

TECHNICAL SKILLS Molecular and Cellular Biology & Biochemistry: Molecular cloning • DNA and RNA purification • PCR • real-time PCR • shRNA • SDS-PAGE • Western blot • Co- Immunoprecipitation • gelatin zymography • soft agar assay • transient transfection • retrovirus • adenovirus or lentivirus-mediated gene transfer • cell-based assays (cell growth • cell viability • apoptosis) • flow cytometry • fluorescence spectroscopy • yeast-two hybrid screening. Tissue Culture: Mammalian adherent and suspension cell culture. Primary cell culture (mouse macrophages and hepatocytes). Animal Handling and Surgery: Extensive experience with mouse handling and surgery • maintenance and breeding of mouse lines • genotyping • generation of tissue-specific genetic knockout mouse lines. Analytical Chemistry: Raman spectroscopy • infrared spectroscopy • gas- chromatography. Statistics and Computer Proficiency: Affymetrix DNA array analysis • Microsoft Office • Adobe Photoshop • BLAST and other database usage • statistical software including SPSS.
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Kun Liu resumes & CV records

Resumes

Kun Liu Photo 39

Kun Liu

Location:
Maumee, OH
Industry:
Higher Education
Work:
Albert Einstein College of Medicine 2011 - 2014
Post-Doctoral Research Fellow
Education:
The University of Toledo 2005 - 2010
Doctorates, Doctor of Philosophy, Philosophy Zhejiang University of Technology 2001 - 2005
Bachelors, Bachelor of Science, Chemistry
Skills:
Molecular Cloning, Dna and Rna Purification, Pcr, Real Time Pcr, Shrna, Sds Page, Western Blot, Co Immunoprecipitation, Gelatin Zymography, Soft Agar Assay, Transient Transfection, Cell Based Assays, Flow Cytometry, Fluorescence Spectroscopy, Yeast Two Hybrid Screening, Mammalian Adherent and Suspension Cell Culture, Primary Cell Culture, Genotyping, Generation of Tissue Specific Genetic Knockout Mouse Lines, Raman Spectroscopy, Infrared Spectroscopy, Gas Chromatography, Affymetrix Dna Array Analysis, Microsoft Office, Adobe Photoshop, Blast and Other Database Usage, Statistical Software Including Spss, Magnetic Bead Separation
Languages:
English
Mandarin
Kun Liu Photo 40

Kun Liu

Kun Liu Photo 41

Kun Liu

Location:
United States
Kun Liu Photo 42

Kun Liu - Maumee, OH

Work:
Albert Einstein College of Medicine - Bronx, NY 2011 to 2014
Post-doctoral Research Fellow
Education:
University of Toledo College of Medicine - Toledo, OH 2005 to 2010
Ph.D. in Biomedical Science Zhejiang University of Technology - Hangzhou, CN 2001 to 2005
B.S. in Analytical Chemistry
Skills:
TECHNICAL SKILLS Molecular and Cellular Biology & Biochemistry: Molecular cloning, DNA and RNA purification, PCR, real-time PCR, shRNA, SDS-PAGE, Western blot, Co- Immunoprecipitation, gelatin zymography, soft agar assay, transient transfection, retrovirus, adenovirus or lentivirus-mediated gene transfer, cell-based assays (cell growth, cell viability, apoptosis), flow cytometry, fluorescence spectroscopy, yeast-two hybrid screening. Tissue Culture: Mammalian adherent and suspension cell culture. Primary cell culture (mouse macrophages and hepatocytes). Animal Handling and Surgery: Extensive experience with mouse handling and surgery, maintenance and breeding of mouse lines, genotyping, generation of tissue-specific genetic knockout mouse lines. Analytical Chemistry: Raman spectroscopy, infrared spectroscopy, gas- chromatography. Statistics and Computer Proficiency: Affymetrix DNA array analysis, Microsoft Office, Adobe Photoshop, BLAST and other database usage, statistical software including SPSS.

Publications & IP owners

Us Patents

2-Aryloxy-2-Arylalkanoic Acids For Diabetes And Lipid Disorders

US Patent:
7091230, Aug 15, 2006
Filed:
Feb 5, 2002
Appl. No.:
10/470954
Inventors:
Alan D. Adams - Cranford NJ, US
A. Brian Jones - Clavering, GB
Joel P. Berger - Hoboken NJ, US
James F. Dropinski - Colts Neck NJ, US
Alexander Elbrecht - Watchung NJ, US
Kun Liu - Edison NJ, US
Karen Lamb MacNaul - Warren NJ, US
Guo-Qiang Shi - Monmouth Junction NJ, US
Derek J. Von Langen - Fanwood NJ, US
Gaochao Zhou - Scotch Plains NJ, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 31/42
C07D 498/00
US Classification:
514378, 514571, 548241, 562463
Abstract:
A class of 2-aryloxy-2-arylalkanoic acids comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, obesity, vascular restenosis, inflammation, and other PPAR alpha and/or gamma mediated diseases, disorders and conditions.

2-Aryloxy-2-Arylalkanoic Acids For Diabetes And Lipid Disorders

US Patent:
7495020, Feb 24, 2009
Filed:
Jan 18, 2006
Appl. No.:
11/334152
Inventors:
Alan D. Adams - Cranford NJ, US
A. Brian Jones - Clavering, GB
Joel P. Berger - Hoboken NJ, US
James F. Dropinski - Colts Neck NJ, US
Alexander Elbrecht - Watchung NJ, US
Kun Liu - Edison NJ, US
Karen Lamb MacNaul - Warren NJ, US
Guo-Qiang Shi - Monmouth Junction NJ, US
Derek J. Von Langen - Fanwood NJ, US
Gaochao Zhou - Scotch Plains NJ, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 31/428
A61K 31/423
US Classification:
514367, 514373, 514 37, 514375, 514379, 548165, 548209, 548221, 548241
Abstract:
A class of 2-aryloxy-2-arylalkanoic acids comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, obesity, vascular restenosis, inflammation, and other PPAR alpha and/or gamma mediated diseases, disorders and conditions.

7-, 8-, And 10-Substituted Amino Triazolo Quinazoline Derivatives As Adenosine Receptor Antagonists, Pharmaceutical Compositions And Their Use

US Patent:
2023005, Feb 23, 2023
Filed:
Nov 26, 2019
Appl. No.:
17/294836
Inventors:
Yonglian ZHANG - Kenilworth NJ, US
Amjad ALI - Kenilworth NJ, US
Jared CUMMING - Winchester MA, US
Duane DEMONG - Boston MA, US
Qiaolin DENG - Kenilworth NJ, US
Thomas H. GRAHAM - Boston MA, US
Elisabeth HENNESSY - Boston MA, US
Matthew A. LARSEN - Boston MA, US
Kun LIU - Boston MA, US
Ping LIU - Boston MA, US
Umar Faruk MANSOOR - Boston MA, US
Jianping PAN - Kenilworth NJ, US
Christopher W. PLUMMER - Kenilworth NJ, US
Aaron SATHER - Boston MA, US
Uma SWAMINATHAN - Boston MA, US
Huijun WANG - Westfield NJ, US
- Rahway NJ, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
A61K 31/519
A61K 39/395
C07D 471/04
C07D 519/00
A61K 31/55
Abstract:
In its many embodiments, the present invention provides certain 7-, 8-, and 10-substituted amino triazolo quinazoline derivatives of Formula (I): or a pharmaceutically acceptable salt thereof, wherein ring A, R1, R2, and R4 are as defined herein, pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other therapeutic agents), and methods for their preparation and use, alone and in combination with other therapeutic agents, as antagonists of A2and/or A2receptors, and their use in the treatment of a variety of diseases, conditions, or disorders that are mediated, at least in part, by the adenosine A2receptor and/or the adenosine A2receptor.

Mineralocorticoid Receptor Antagonists

US Patent:
2014025, Sep 11, 2014
Filed:
Oct 8, 2012
Appl. No.:
14/350888
Inventors:
- Rahway NJ, US
Christine Yang - Jersey City NJ, US
Jason M. Cox - East Windsor NJ, US
Kun Liu - Needham MA, US
International Classification:
C07D 413/04
A61K 31/4439
A61K 31/5377
A61K 31/506
A61K 31/422
C07D 413/14
US Classification:
5142345, 548226, 514376, 544137, 544333, 514256, 5462714, 514338
Abstract:
The present invention is directed to compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof that are aldosterone receptor antagonists which might be useful for treating aldosterone-mediated diseases. The invention furthermore relates to processes for preparing compounds of the Formula (I), to their possible use for the treatment of the above-mentioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical compositions which comprise compounds of the Formula (I).

Selective Glycosidase Inhibitors And Uses Thereof

US Patent:
2014008, Mar 27, 2014
Filed:
Mar 20, 2012
Appl. No.:
14/008388
Inventors:
Ramesh Kaul - Burnaby, CA
Ernest J. McEachern - Burnaby, CA
David J. Vocadlo - Burnaby, CA
Yuanxi Zhou - Burnaby, CA
Kun Liu - Rahway NJ, US
Harold G. Selnick - West Point PA, US
Zhongyong Wei - Beijing, CN
Changwei Mu - Beijing, CN
Yaode Wang - Beijing, CN
Xiaona Wang - Beijing, CN
International Classification:
C07H 19/24
US Classification:
514 24, 536 174, 435184
Abstract:
The invention provides compounds of formula (I) with substituents as specified in Claim for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceuticals compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to over-expression of O-GlcNAcase or accumulation of O-GlcNac.

Possible Relatives

Cynthia S Liu  David Y Liu  Dean Liu  Da J Liu  Debbie Y Liu  Dan Liu  Kun I Lee  Kun B Pak  Kun C Peng 

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