Peng C Tang, 69New Brunswick, NJ

5783568, Jul 21, 1998

Jun 10, 1994

8/258307

Joseph Schlessinger - New York NY
Irit Lax - Fair Lawn NJ
John E. Ladbury - New York NY
Peng Cho Tang - Moraga CA

Sugen, Inc. - Redwood City CA
New York University - New York NY

A61K 31715
C08B 3710

514 53

The present invention relates to a method of treating in a mammal certain cancers, other cell proliferative diseases, and/or angiogenesis by using a salt or complex of a sulfated saccharide. The invention also relates to the use of mutant heparin binding growth factors that bind to the growth factor receptor, but not to heparin. The invention also provides pharmaceutical compositions for such methods.

5075327, Dec 24, 1991

Nov 14, 1988

7/270991

Peng C. Tang - Bloomfield NJ
Milan R. Uskokovic - Upper Montclair NJ

Hoffmann-La Roche Inc. - Nutley NJ

A61K 3135
C07D30930

514460

A compound and process of making thereof of formula ##STR1## wherein R. sub. 1 is hydrogen; and A is alkyl; cycloalkyl; alkenyl; alkyl substituted with trifluoromethyl; phenyl; halophenyl; phenyl-C. sub. 1-3 alkyl; phenyl-C. sub. 1-3 alkyl substituted on the phenyl with 1 to 3 substituents selected from the group consisting of halo, C. sub. 1-3 alkyl, and C. sub. 1-3 alkoxy; or A is ##STR2## wherein Z is lower alkyl; R. sub. 2 is hydrogen or ##STR3## R. sub. 3 is hydrogen or methyl, and n is 1 to 5; Y is phenyl, is phenyl substituted by 1 to 3 substituents selected from the group consisting of halo, lower alkyl, and lower alkoxy; Y' is hydrogen or methyl; and b and d are carbon-carbon bonds or c is a carbon-carbon bond; or the corresponding hydroxy acid of formula ##STR4## wherein A, and R. sub. 1, R. sub. 2, R. sub. 3, Y and Y' are as described above, or a pharmaceutically acceptable salt of said acid, an alkyl ester of said acid, an acetylamino-substituted-C. sub. 1-4 alkyl ester of said acid, a phenyl-dimethylamino ester of said acid or a. alpha.