Inventors:
Jeffrey O. Saunders - Acton MA
Daniel Elbaum - Newton MA
Perry M. Novak - Milford MA
Douglas Naegele - Washington DC
Randy S. Bethiel - Cambridge MA
Steven M. Ronkin - Watertwon MA
Michael C. Badia - Bedford MA
Catharine Frank - Langhorne PA
Dean P. Stamos - Framingham MA
William Walters - Waltham MA
David Pearlman - Arlington MA
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
C07D25102
US Classification:
514242, 564100, 564161, 564162, 564163, 564168, 564169, 564173, 514249, 51425201, 51425505, 5142521, 5142581, 5142631, 5142632, 514269, 514299, 514300, 514345, 514306, 514307, 514311, 514336, 514363, 514365, 514372, 514374, 514378, 514383, 514406, 514438, 514469, 514476
Abstract:
The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.