Peter Senter resumes & CV records
Resumes
Peter Senter
Peter Senter
Location:
United States
Peter Stephen Senter, 74Staunton, VA
Peter Senter Phones & Addresses
Staunton, VA
Point Reyes Station, CA
Grass Valley, CA
Cromberg, CA
Portola, CA
Quincy, CA
San Rafael, CA
Petaluma, CA
15568 Keson Pl, Grass Valley, CA 95949
Work
Position:
Administrative Support Occupations, Including Clerical Occupations
Education
Degree:
Bachelor's degree or higher
Mentions for Peter Stephen Senter
Publications & IP owners
Us Patents
Methods Of Using Monomethylvaline Compositions Having Phenylalanine Carboxy Modifications At The C-Terminus
US Patent:
2015004, Feb 12, 2015
Filed:
Sep 30, 2014
Appl. No.:
14/502210
Inventors:
- Bothell WA, US
Toni Beth Kline - San Francisco CA, US
Scott Jeffrey - Snohomish WA, US
Peter D Senter - Seattle WA, US
Damon Meyer - Bellevue WA, US
Toni Beth Kline - San Francisco CA, US
Scott Jeffrey - Snohomish WA, US
Peter D Senter - Seattle WA, US
Damon Meyer - Bellevue WA, US
Assignee:
SEATTLE GENETICS, INC. - Bothell WA
International Classification:
A61K 47/48
A61K 39/395
C07K 16/28
A61K 39/395
C07K 16/28
US Classification:
4241811
Abstract:
Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) having a carboxylic acid equivalent at the C-terminal phenylalanine were prepared and attached to ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand-drug conjugates were active in vitro and in vivo in inhibiting cell proliferation and are represented by the general structure ofwherein L- is Ligand unit; LU is a Linker unit (LU); v is 1; p is an number ranging from about 1 to about 20; and D is a drug moiety having the formula:wherein the moiety —N(R)Zis a phenylalanine bioisostere, wherein Zis —CH(R)Zso that the phenylalanine bioisostere has the structure of Formula A:and wherein the substituents R-R, Xand Zare as defined.
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