Peter P Speck Deceased8519 Massasoit Ave, Oak Lawn, IL 60459
Peter Speck Phones & Addresses
8519 Massasoit Ave, Burbank, IL 60459
Oak Lawn, IL
Frankfort, IL
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Peter Speck House
Peter Speck House is a historic home located near Martinsburg, Berkeley County, West Virginia. It was built between 1814 and 1815, and consists of a two story, ...
Us Patents
Recombinant Virus Vectors
US Patent:
2002003, Mar 28, 2002
Filed:
Apr 10, 2001
Appl. No.:
09/833206
Inventors:
Peter Speck - Chicago IL, US
International Classification:
C12N015/869
C12N007/01
A61K048/00
A01N063/00
A61K039/12
A61K039/245
A61K039/255
A61K039/265
A61K039/27
C12N007/00
C12N007/04
C12N015/86
C12N007/01
A61K048/00
A01N063/00
A61K039/12
A61K039/245
A61K039/255
A61K039/265
A61K039/27
C12N007/00
C12N007/04
C12N015/86
US Classification:
435/236000, 435/235100, 435/456000, 424/199100, 424/205100, 424/229100, 424/231100, 424/093200
Abstract:
A mutant herpesvirus that can be used as a recombinant virus vector comprises (a) a mutation such that the mutant virus has a reduced ability in comparison with a parent type to cause lysis of an infected cell, and (b) an inactivating mutation in a gene essential for the production of infectious virus. An example is a HSV1 mutant lacking the essential glycoprotein gH gene and having a mutation impairing the function of gene product VP16. A heterologous gene can be carried at the site of the inactivated essential gene, e.g. a gene suitable for administering gene therapy. The vector has an increased margin of safety over known herpesvirus vectors in respect of incidence of cytopathic effects and/or risk of reversion.
Recombinant Virus Vectors
US Patent:
6319703, Nov 20, 2001
Filed:
Apr 25, 1997
Appl. No.:
8/776497
Inventors:
Peter G. Speck - Chicago IL
International Classification:
C12N 700
C12N 701
C12N 704
C12N 15869
C12N 701
C12N 704
C12N 15869
US Classification:
4352351
Abstract:
A mutant herpesvirus that can be used a recombinant virus vector includes (a) a mutation such that the mutant virus has a reduced ability in comparison with a parent type to cause lysis of an infected cell, and (b) an inactivating mutation in a gene essential for the production of infectious virus. An example is a HSV1 mutant lacking the essential glycoprotein gH gene and having a mutation impairing the function of the gene product VP16. A heterologous gene can be carried at the site of the inactivated essential gene, e. g. a gene suitable for administering gene therapy. The vector has an increased margin of safety over known herpesvirus vectors in respect of incidence of cytopathic effects and/or risk of infection.
Isbn (Books And Publications)
Letting Go: Caring For The Dying And The Bereaved
Author:
Peter W. Speck
ISBN #:
0281038619
Loss And Grief In Medicine
Author:
Peter W. Speck
ISBN #:
0702006815
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