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Rajiv RatanRedlands, CA

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Staten Island, NY   

Yucca Valley, CA   

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Rajiv Ratan

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Us Patents

Stimulating Neurite Outgrowth Using Tctex-1-Related Polypeptides

US Patent:
8168749, May 1, 2012
Filed:
Oct 17, 2008
Appl. No.:
12/253428
Inventors:
Ching-Hwa Sung - New York NY, US
Rajiv Ratan - Scarsdale NY, US
Assignee:
Cornell Research Foundation, Inc. - Ithaca NY
International Classification:
C07K 14/00
C12P 21/04
C12N 15/00
A61K 49/00
A61K 35/30
US Classification:
530350, 530402, 435 697, 424 91, 424570
Abstract:
A method of stimulating neurite outgrowth in a subject may include administering to the subject a formulation that includes a tctex-1-related polypeptide that stimulates neurite outgrowth in vitro.

Methods For Stimulating Nervous System Regeneration And Repair By Regulating Arginase I And Polyamine Synthesis

US Patent:
2003021, Nov 20, 2003
Filed:
Apr 7, 2003
Appl. No.:
10/275513
Inventors:
Marie Filbin - New York NY, US
Rajiv Ratan - Cambridge MA, US
International Classification:
A61K048/00
C12N005/08
US Classification:
424/093210, 435/368000
Abstract:
This invention relates to the novel identification of arginase as an enzymatic activity which can reverse inhibition of neuronal regeneration in the central and peripheral nervous system. Assays to monitor the effects of various agents on arginase expression and thus on neuronal regeneration and repair and to identify agents which will block or promote the inhibitory effects on neuronal outgrowth are provided. This invention also relates to compositions and methods using agents that can reverse the inhibitory effects of myelin on neural regeneration by affecting arginase activity or putrescine and derivative polyamine levels in a neuron. Methods for regulating and for promoting (or repressing) neuronal growth or regeneration in the nervous system, methods for treating injuries or damage to nervous tissue or neurons, and methods for treating neural degeneration associated with conditions, disorders or diseases, comprising the step of administering at least one of the compositions according to this invention, are provided.

Treating Disorders Of The Nervous System

US Patent:
2007011, May 24, 2007
Filed:
Jun 30, 2006
Appl. No.:
11/428122
Inventors:
Ching-Hwa Sung - New York NY, US
Rajiv Ratan - Scarsdale NY, US
International Classification:
A61K 38/17
C07K 14/705
C07H 21/04
C12P 21/06
A61K 48/00
C12N 5/08
US Classification:
514012000, 530350000, 435069100, 435320100, 435325000, 536023500, 514044000, 435368000
Abstract:
A polypeptide may include an amino acid sequence having at least about 95% identity to the amino acid sequence of SEQ ID NO: 42, wherein a residue at position 94 of the polypeptide is an amino acid other than threonine or wherein a residue at position 82 of the polypeptide is an amino acid other than serine. A polypeptide may include at least the first 14 residues and at most the first 92 residues of an amino acid sequence starting with residue 1 of, and having at least about 95% identity to, the amino acid sequence of SEQ ID NO: 1, 3, 5, 7, 9, 11, 13, 15, 16, or 17. Such polypeptide may stimulate neurite outgrowth or neurogenesis. A nucleic acid may encode the polypeptide. A vector may include the nucleic acid. A host cell, such as an embryonic stem cell, may include the vector.

Compounds For Enhancing Hypoxia Inducible Factor Activity And Methods Of Use

US Patent:
2009021, Aug 27, 2009
Filed:
Oct 20, 2006
Appl. No.:
12/083891
Inventors:
Rajiv R. Ratan - Scarsdale NY, US
Ambreena Siddiq - White Plains NY, US
Juan C. Chavez - Limerick PA, US
Assignee:
CORNELL RESEARCH FOUNDATION, INC. - Ithaca NY
International Classification:
A61K 38/00
A61K 31/352
A61K 31/343
A61K 31/24
A61P 25/00
US Classification:
514 12, 514455, 514468, 514510
Abstract:
The present invention relates to methods for enhancing Hypoxia inducible factor-1 (HIF) activity in a cell by contacting the cell with any one of the following compounds: 3,6-bis[2-(dimethylamino)ethoxy]-9h-xanthen-9-onedihydrochloride, 2,8-bis[dimethylaminoacetyl]dibenzofurin dihydrochloride hydrate, tilorone analogue R-9536-DA, indoprofen, ciclopiroxolamine, tryptophan, ansindione, nabumetone, oxybendazole, albendazole, tropicamide, pramoxine hydrochloride, atenolol, mebendazole, carbetapentane citrate, monensin sodium, methoxyvone, hydroxyzine, phenazopyridine, clofoctol, ipraflavone, zomepirac, biochanin A, xylometazoline hydrochloride, fenbendazole, pirenzepine, triprolidine hydrochloride, daidzein, tripelennamine citrate, colchicines, aminopyridine, trimethoprim, helenine, hydroxyurea, amiodarone hydrochloride, clindamycin hydrochloride, sulfachlorpyridazine, mephenesin, semustine, clofivric acid, clofibrate, ibuprofen, hyoscyamime, nafcillin sodium, piperin, clidinium bromide, trioxsalen, hydralazine and HIF alpha protein fused to a carrier peptide.

Compounds For Enhancing Arginase Activity And Methods Of Use Thereof

US Patent:
2009025, Oct 8, 2009
Filed:
Jul 18, 2007
Appl. No.:
12/309500
Inventors:
Rajiv R. Ratan - Scarsdale NY, US
Marie T. Filbin - New York NY, US
International Classification:
A61K 31/352
A61P 25/28
US Classification:
514454
Abstract:
The present invention relates to a method for enhancing arginase activity in a damaged or injured cell. In other aspects, the invention provides a method for treating a disorder that can be treated by enhancing arginase activity in a human in need thereof, the method comprising administering to the human an effective amount of a compound that enhances arginase activity. Such disorders include ischemia, hypoxia, neurodegenerative disease or condition, stroke or trauma of the nervous system. In yet another aspect, the invention provides methods for promoting regeneration of a neural cell in a human in need thereof.

Compounds For Enhancing P21 Expression And Methods Of Use Thereof

US Patent:
2010016, Jul 1, 2010
Filed:
Jun 5, 2008
Appl. No.:
12/663091
Inventors:
Rajiv R. Ratan - Scarsdale NY, US
Brett C. Langley - White Plains NY, US
Brian S. Ko - Hastings-on-Hudson NY, US
Assignee:
CORNELL UNIVERSITY - Ithaca NY
International Classification:
A61K 38/12
C12Q 1/68
A61K 31/44
A61K 31/675
A61K 31/4745
A61K 31/35
A61K 31/17
A61K 31/195
A61P 25/00
A61P 25/16
A61P 25/28
US Classification:
514 9, 435 6, 514345, 514 82, 514283, 514456, 514596, 514562
Abstract:
The present invention relates to a method for identifying a drug candidate for enhancing expression of p21ctpl/wafl in a human patient suffering from a medical condition that can be treated by enhancing expression of p21Cφl/wafl. The method includes (a) providing a cell line comprising a nucleic acid sequence that comprises a p21ctpl/wafl promoter operationally ligated to a reporter domain; (b) exposing the cell line to a compound; and (c) identifying a compound that induces expression of the reporter domain. The compound that induces expression of the reporter domain is a drug candidate for treating a medical condition that can be treated by enhancing expression of p21cipl/wafl.

Methods For Stimulating Nervous System Regeneration And Repair By Regulating Arginase I And Polyamine Synthesis

US Patent:
2010021, Aug 26, 2010
Filed:
Nov 5, 2009
Appl. No.:
12/613310
Inventors:
Marie T. Filbin - New York NY, US
Rajiv R. Ratan - Cambridge MA, US
Assignee:
Research Foundation of the City University of New York - New York NY
International Classification:
A61K 38/18
C07K 14/475
C07K 14/485
C07K 14/49
C07K 14/50
C07H 21/04
A61K 31/7088
A61P 25/00
A61P 25/28
A61P 25/16
US Classification:
514 12, 530399, 536 2351, 536 232, 514 44 R, 435 18
Abstract:
This invention relates to the novel identification of arginase as an enzymatic activity which can reverse inhibition of neuronal regeneration in the central and peripheral nervous system. Assays to monitor the effects of various agents on arginase expression and thus on neuronal regeneration and repair and to identify agents which will block or promote the inhibitory effects on neuronal outgrowth are provided. This invention also relates to compositions and methods using agents that can reverse the inhibitory effects of myelin on neural regeneration by affecting arginase activity or putrescine and derivative polyamine levels in a neuron. Methods for regulating and for promoting (or repressing) neuronal growth or regeneration in the nervous system, methods for treating injuries or damage to nervous tissue or neurons, and methods for treating neural degeneration associated with conditions, disorders or diseases, comprising the step of administering at least one of the compositions according to this invention, are provided.

Atf4 Inhibitors And Their Use For Neural Protection, Repair, Regeneration, And Plasticity

US Patent:
2011028, Nov 24, 2011
Filed:
Aug 4, 2008
Appl. No.:
12/672013
Inventors:
Rajiv R. Ratan - Scarsdale NY, US
Assignee:
CORNELL UNIVERSITY - Ithaca NY
International Classification:
A61K 49/00
C12Q 1/02
A61K 31/305
A61K 31/35
A61K 31/555
A61K 31/16
A61K 31/7028
A61K 31/5415
A61K 31/19
A61K 38/12
A61K 31/135
A61K 31/05
A61K 31/43
A61K 31/454
A61K 31/155
A61K 31/519
A61K 31/4375
A61K 31/52
A61K 31/137
A61K 31/4406
A61K 31/573
A61K 31/381
A61K 31/351
A61K 31/435
A61K 31/407
A61P 25/28
A61P 25/24
A61P 25/18
A61P 25/00
A61P 35/00
C12Q 1/68
US Classification:
424 92, 435 613, 435 29, 514496, 514453, 514188, 514599, 514 27, 5142242, 514557, 514 177, 514 178, 514646, 514736, 514192, 514323, 514635, 514249, 514283, 5142633, 514653, 514356, 514181, 514444, 514456, 514297, 514410
Abstract:
In one aspect, the invention relates to a method for identifying a drug candidate with activity as a neuroprotective agent. The method includes determining whether a compound reduces ATF4 activity; and identifying the compound that reduces ATF4 activity as a drug candidate.

Isbn (Books And Publications)

Cell Death And Diseases Of The Nervous System

Author:
Rajiv R. Ratan
ISBN #:
0896034135

Possible Relatives

Ku K Ratan  Rajiv Singh  Rajiv Prasad  Rajiv P Das  Rajiv A Ali  Rajiv M Rao  Rajiv Sethi  Rajiv Arora  Rajiv K Bhardwaj  Rajiv K Gulati 

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