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Ralph A Backhaus, 741530 W Juanita Ave, Mesa, AZ 85202

Ralph Backhaus Phones & Addresses

3716 Rocky Slope Dr, Phoenix, AZ 85044    480-7066449   

Mesa, AZ   

3716 E Rocky Slope Dr, Phoenix, AZ 85044    520-7808183   

Work

Position: Professional/Technical

Education

Degree: Graduate or professional degree

Mentions for Ralph A Backhaus

Ralph Backhaus resumes & CV records

Resumes

Ralph Backhaus Photo 8

Ralph Backhaus

Location:
Phoenix, Arizona Area
Industry:
Biotechnology
Ralph Backhaus Photo 9

Ralph Backhaus

Publications & IP owners

Us Patents

Cardioprotective Therapies Based On Enzymatic Elimination Of Lipid Peroxides By Allene Oxide Synthase

US Patent:
7157082, Jan 2, 2007
Filed:
Jul 30, 2003
Appl. No.:
10/630548
Inventors:
Ralph A. Backhaus - Phoenix AZ, US
Assignee:
Arizona Board of Regents - Tempe AZ
International Classification:
A01N 61/00
US Classification:
424 941, 435232, 435233
Abstract:
The present invention relates to methods and compositions related to the use of enzymes of the allene oxide synthase family for reducing myocardial ischemia reperfusion injury associated with myocardial infarction, thrombolysis, angioplasty and coronary bypass surgery. The methods of the invention comprise administration of allene oxide synthases, which are capable of eliminating lipid hydroperoxides, as a potent cardioprotective agent. The invention is based on the discovery that administration of allene oxide synthase following severe global ischemia stimulates cardiac recovery.

Rubber Particle Protein Gene From Guayule

US Patent:
5633433, May 27, 1997
Filed:
May 9, 1994
Appl. No.:
8/240012
Inventors:
Ralph A. Backhaus - Mesa AZ
Zhiqiang Pan - Tempe AZ
Assignee:
Arizona Board of Regents, a body corporate of the State of Arizona,
acting for and on behalf of Arizona State University - Tempe AZ
International Classification:
C12N 1529
C12N 1563
A01H 100
A01H 500
US Classification:
800205
Abstract:
Guayule rubber particles, contain several characteristic proteins. The most abundant of these proteins, the rubber particle protein (RPP) has been shown to be a non-monooxygenase, cytochrome P450, heme-binding protein that is necessary for rubber biosynthesis. A full-length cDNA clone for guayule RPP has been isolated, sequenced and characterized. The pRPP30 coding sequence is transferable to other prokaryotic or eukaryotic host organisms wherein the RPP DNA will be expressed to produce functional RPP for rubber biosynthesis.

Enzymatic Antioxidant Of Allene Oxide For Lipid Peroxidation In Biological Systems

US Patent:
6132711, Oct 17, 2000
Filed:
Jul 17, 1997
Appl. No.:
8/896162
Inventors:
Ralph A. Backhaus - Phoenix AZ
Zhiqiang Pan - Davis CA
Lisa A. Herickhoff - Fort Collins CO
Assignee:
Arizona Board of Regents - Tempe AZ
International Classification:
A61K 3843
C11B 900
C08B 300
C08B 500
US Classification:
424 941
Abstract:
The present invention relates to the isolation and use of an allene oxide synthase enzyme as an antioxidant of lipid peroxides in biological systems. It is based, at least in part, on the discovery that antioxidation is accomplished enzymatically by RPP, a species of allene oxide synthase, in guayule, and on the discovery that the allene oxide synthase RPP disrupts the chain reaction and propagation steps of lipid peroxidation. The present further invention relates to the use of an allene oxide synthase to result in a time-dependent disappearance of conjugated dienes (i. e. lipid hydroperoxides). The allene oxide synthase rapidly converts free or esterified fatty acid peroxides or hydroperoxides into their corresponding epoxides, which, in turn are converted to ketols. The lipid peroxide and hydroperoxide substrates for this enzyme are known to be toxic to biological organisms and can generate additional peroxides by chain propagation reactions. In the presence of an allene oxide synthase these compounds are rapidly and effectively converted to allene oxides (the epoxide), thus breaking the chain reaction.

Isbn (Books And Publications)

Casus Perplexus: Die Losung In Sich Widerspruchlicher Rechtsfalle Durch Die Klassische Romische Jurisprudenz

Author:
Ralph Backhaus
ISBN #:
3406076726

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