Randy K Bower, 64298 Fishers Rd, Pittsford, NY 14534

8026101, Sep 27, 2011

Mar 28, 2005

11/091283

Randy Kristopher Bower - Pittsford NY, US
Stuart Gilmour MacDonald - Pultneyville NY, US
James David Shaw - Hilton NY, US
Mark Alan Simon - Pittsford NY, US
Michael Avdenko - Rochester NY, US
Joseph John Dambra - Rochester NY, US
David Donald Hyde - Ontario NY, US
Merrit Nyles Jacobs - Fairport NY, US
James Daniel Riall - Roanoke VA, US

Ortho-Clinical Diagnostics, Inc. - Rochester NY

B01L 3/02

436 43, 436 54, 436180, 422501

The invention is a method for detecting failures in an analyzer for conducting clinical assays. Potential errors that can result in assay failures in an analyzer are identified, as are their potential sources. The probability that an error source so identified will result in a clinically significant error is also determined. Available potential detection measures corresponding to the source of potential errors are identified with a combination of such measures selected and implemented based on their probability of detecting such errors within an acceptable limit with a concomitant low probability of the false detection of an assay failure. Each of the measures selected are functionally independent of others chosen to address the source of the error and are not subject to the same inherent means of failed detection. Applications of the method in a clinical analyzer are also presented.

2004006, Apr 8, 2004

Oct 2, 2002

10/263069

Nicholas VanBrunt - Rochester NY, US
Randy Bower - Pittsford NY, US
Robert Burkovich - Pittsford NY, US
Joseph Dambra - Rochester NY, US

Ortho-Clinical Diagnostics, Inc.

G01N035/00

422/063000, 436/008000, 436/043000, 436/050000, 422/067000

A method for measuring the amount of fluid contained in a reaction vessel in a clinical analyzer includes the steps of adding a first aliquot of fluid to the reaction vessel and measuring the quantity of fluid contained therein. A second aliquot of fluid is then added to the reaction vessel and the quantity of fluid contained therein is also measured. Measurement of the two fluid quantities can occur with or without removal of the first aliquot in between measurements. In obtaining the two quantity measurements and comparing them against a standard, the effects of well geometry can be minimized. Preferably, a delta or ratio measurement is obtained between the first and second liquid volume measurements which can be compared against a standard so as to normalize apparent volume losses or gains due to reaction well dimensional variation. This approach enhances the analytical capability to detect true fluid delivery errors.

2013033, Dec 12, 2013

Jun 11, 2013

13/914678

Randy K. Bower - Pittsford NY, US
Joseph J. Dambra - Rochester NY, US
Zhong Ding - Pittsford NY, US
James E. Robinson - Rochester NY, US
Dale R. Ryan - Fairport NY, US
David A. Tomasso - Rochester NY, US

G01N 33/543

435 5, 4352872, 436501, 435 72, 422 69, 422 63

A lateral flow device for use in a mainframe or point-of-care clinical analyzer, in which the lateral flow device includes a planar support having at least one sample addition area and at least one reaction area disposed thereon. The sample addition area and reaction area are fluidly interconnected to one another and form at least one lateral fluid flow path. The lateral flow device is sized for retention within a storage cartridge of the analyzer defined by a hollow interior and having a plurality of lateral flow assay devices retained in stacked relation therein.

2016032, Nov 3, 2016

Jul 8, 2016

15/205029

- Raritan NJ, US
Randy K. Bower - Pittsford NY, US
Joseph J. Dambra - Rochester NY, US
Zhong Ding - Pittsford NY, US
James E. Robinson - Rochester NY, US
Dale R. Ryan - Fairport NY, US
David A. Tomasso - Rochester NY, US

G01N 33/543
G01N 35/10

A lateral flow device for use in a mainframe or point-of-care clinical analyzer, in which the lateral flow device includes a planar support having at least one sample addition area and at least one reaction area disposed thereon. The sample addition area and reaction area are fluidly interconnected to one another and form at least one lateral fluid flow path. The lateral flow device is sized for retention within a storage cartridge of the analyzer defined by a hollow interior and having a plurality of lateral flow assay devices retained in stacked relation therein.

2016002, Jan 28, 2016

Jul 22, 2015

14/805712

- Raritan NJ, US
Joseph J. Dambra - Rochester NY, US
Randy K. Bower - Pittsford NY, US

G01N 33/53

An assay device includes a support, test elements arranged thereover, and a diverter defining a common sample addition area of the device. The diverter conducts respective portions of a fluidic sample from the area to each of the test elements. Another assay device includes the test elements, one a dry slide element, disposed over the support at least partly in proximity to each other to define a common sample addition area. Apparatus for analyzing a sample includes an assay device having the test elements, one a dry slide element. A controller operates a metering mechanism, to apply the sample to the assay device, an incubator, and a measurement device per a timing protocol to determine a characteristic of the sample. Methods for enabling an assay device to perform multiple tests based upon a single sample metering event include are also described.