Raymond R Hebert, 70304 Clark St, Crockett, CA 94525

6369893, Apr 9, 2002

May 19, 1999

09/314605

Lee A. Christel - Palo Alto CA
M. Allen Northrup - Berkeley CA
Kurt E. Petersen - San Jose CA
William A. McMillan - Cupertino CA
Gregory T. A. Kovacs - Stanford CA
Steven J. Young - Los Gatos CA
Ronald Chang - Redwood City CA
Douglas B. Dority - Mill Valley CA
Raymond T. Hebert - Los Gatos CA
Gregory J. Kintz - Mountain View CA

Cepheid - Sunnyvale CA

G01N 2164

356417, 2504581, 422 8208, 436172

An apparatus for thermally controlling and optically interrogating a reaction mixture includes a vessel [ ] having a chamber [ ] for holding the mixture. The apparatus also includes a heat-exchanging module [ ] having a pair of opposing thermal plates [ A, B] for receiving the vessel [ ] between them and for heating/and or cooling the mixture contained in the vessel. The module [ ] also includes optical excitation and detection assemblies [ ] positioned to optically interrogate the mixture. The excitation assembly [ ] includes multiple light sources [ ] and a set of filters for sequentially illuminating labeled analytes in the mixture with excitation beams in multiple excitation wavelength ranges. The detection assembly [ ] includes multiple detectors [ ] and a second set of filters for detecting light emitted from the chamber [ ] in multiple emission wavelength ranges. The optics assemblies [ ] thus provide a multi-channel system for detecting a plurality of different target analytes in the mixture.

6940598, Sep 6, 2005

Apr 8, 2002

10/119228

Lee A. Christel - Palo Alto CA, US
M. Allen Northrup - Berkeley CA, US
Kurt E. Petersen - Santa Clara CA, US
William A. McMillan - Cupertino CA, US
Gregory T. A. Kovacs - Stanford CA, US
Steven J. Young - Los Gatos CA, US
Ronald Chang - Redwood City CA, US
Douglas B. Dority - Mill Valley CA, US
Raymond T. Hebert - Los Gatos CA, US
Gregory J. Kintz - Mountain View CA, US

Cepheid - Sunnyvale CA

G01N021/64

356417, 2504581, 422 8208, 436172

An apparatus for thermally controlling and optically interrogating a reaction mixture includes a vessel [] having a chamber [] for holding the mixture. The apparatus also includes a heat-exchanging module [] having a pair of opposing thermal plates [A, B] for receiving the vessel [] between them and for heating/and or cooling the mixture contained in the vessel. The module [] also includes optical excitation and detection assemblies [] positioned to optically interrogate the mixture. The excitation assembly [] includes multiple light sources [] and a set of filters for sequentially illuminating labeled analytes in the mixture with excitation beams in multiple excitation wavelength ranges. The detection assembly [] includes multiple detectors [] and a second set of filters for detecting light emitted from the chamber [] in multiple emission wavelength ranges. The optics assemblies [] thus provide a multi-channel system for detecting a plurality of different target analytes in the mixture.

7002688, Feb 21, 2006

Jun 9, 2004

10/865100

Alexander M. Aravanis - Palo Alto CA, US
Raymond T. Hebert - Los Gatos CA, US
Bryan E. Loucks - Los Altos Hills CA, US
John D. Lytle - Santa Cruz CA, US
Jason L. Pyle - Palo Alto CA, US

Pria Diagnostics, Inc. - Menlo Park CA

G01N 21/64

356417, 2504581

A diagnostics apparatus for detecting fluorescence events related to the presence of an analyte in a sample is disclosed. The apparatus includes a housing, a source of excitation light and a photodetector, and a unitary multi-surface optical module. The optical module is integrally formed and composed of an upstream portion having a focusing optical surface for directing excitation light from the light source to a focal region within an analyte-detection zone in the apparatus, and a downstream portion having a second focusing powered optical surface and at least one reflecting surface for directing fluorescence-emission light produced by fluorescence events within the detection zone, in a direction substantially normal to the path of the excitation light onto the photodetector. The optical module is adaptable to a variety of assay formats, including multiple-sample, sample-array, and disposable-cartridge formats.