Ren He Wei Liu, 461832 Sobrante Ct, Walnut Creek, CA 94595

2021027, Sep 9, 2021

Oct 22, 2020

17/077514

- Los Angeles CA, US
Ren Liu - Azusa CA, US
Amy Lee - Los Angeles CA, US

C07K 16/28
C07K 16/18
C07K 16/30
A61K 49/00
A61K 47/68
G01N 33/574

This application provides, inter alia, antibodies or antigen-binding fragments thereof, targeting cell surface GRP78 expressed on tumor cells, tumor endothelial cells, and tumor initiating cancer cells. These anti-GRP78 antibodies, or antigen-binding fragments thereof, have a high affinity for GRP78 and are less immunogenic compared to their unmodified parent antibodies in a given species, e.g., a human, and function to inhibit GRP78. Importantly, these isolated novel antibodies and antigen-binding fragments thereof, attenuate PI3K signaling and promote apoptosis in tumor cells, while leaving normal cells unaffected. The antibodies and antigen-binding fragments are useful for UPR-targeted cancer therapeutic treatments.

2020014, May 7, 2020

Jun 11, 2019

16/438289

- Los Angeles CA, US
Ren Liu - Azusa CA, US
Amy Lee - Los Angeles CA, US

C07K 16/28
A61K 47/68
C07K 16/18
C07K 16/30
A61K 49/00
G01N 33/574

This application provides, inter alia, antibodies or antigen-binding fragments thereof, targeting cell surface GRP78 expressed on tumor cells, tumor endothelial cells, and tumor initiating cancer cells. These anti-GRP78 antibodies, or antigen-binding fragments thereof, have a high affinity for GRP78 and are less immunogenic compared to their unmodified parent antibodies in a given species, e.g., a human, and function to inhibit GRP78. Importantly, these isolated novel antibodies and antigen-binding fragments thereof, attenuate PI3K signaling and promote apoptosis in tumor cells, while leaving normal cells unaffected. The antibodies and antigen-binding fragments are useful for UPR-targeted cancer therapeutic treatments.

2018009, Apr 5, 2018

May 9, 2017

15/590379

Parkash Gill - Agoura CA, US
Ren Liu - Azusa CA, US

C07K 16/28
G01N 33/574
A61K 49/00
C07K 16/18
C07K 16/30
A61K 39/00

This application provides, inter alia, antibodies or antigen-binding fragments thereof, targeting cell surface GRP78 expressed on tumor cells, tumor endothelial cells, and tumor initiating cancer cells. These anti-GRP78 antibodies, or antigen-binding fragments thereof, have a high affinity for GRP78 and are less immunogenic compared to their unmodified parent antibodies in a given species, e.g., a human, and function to inhibit GRP78. Importantly, these isolated novel antibodies and antigen-binding fragments thereof, attenuate PI3K signaling and promote apoptosis in tumor cells, while leaving normal cells unaffected. The antibodies and antigen-binding fragments are useful for UPR-targeted cancer therapeutic treatments.

2016018, Jun 30, 2016

Mar 14, 2014

14/776659

Parkash Gill - Agoura CA, US
Ren Liu - Azusa CA, US

C07K 16/28
G01N 33/574
C07K 16/30

This application provides, inter alia, antibodies or antigen-binding fragments thereof, targeting cell surface GRP78 expressed on tumor cells, tumor endothelial cells, and tumor initiating cancer cells. These anti-GRP78 antibodies, or antigen-binding fragments thereof, have a high affinity for GRP78 and are less immunogenic compared to their unmodified parent antibodies in a given species, e.g., a human, and function to inhibit GRP78. Importantly, these isolated novel antibodies and antigen-binding fragments thereof, attenuate PI3K signaling and promote apoptosis in tumor cells, while leaving normal cells unaffected. The antibodies and antigen-binding fragments are useful for UPR-targeted cancer therapeutic treatments.

2015004, Feb 19, 2015

Aug 15, 2014

14/460683

John C. Forster - Mountain View CA, US
Joseph Yudovsky - Campbell CA, US
Garry K. Kwong - San Jose CA, US
Tai T. Ngo - Dublin CA, US
Kevin Griffin - Livermore CA, US
Kenneth S. Collins - San Jose CA, US
Ren Liu - Sunnyvale CA, US

H01J 37/32

31511121

A modular plasma source assembly for use with a processing chamber is described. The assembly includes an RF hot electrode with an end dielectric and a sliding ground connection positioned adjacent the sides of the electrode. A seal foil connects the sliding ground connection to the housing to provide a grounded sliding ground connection separated from the hot electrode by the end dielectric. A coaxial feed line passes through a conduit into the RF hot electrode isolated from the processing environment so that the coaxial RF feed line is at atmospheric pressure while the plasma processing region is at reduced pressure.