Lawrence S Marlin Deceased7 Wight St, Bridgewater, NJ 08807

5558900, Sep 24, 1996

Sep 22, 1994

8/310723

You-Ling Fan - East Brunswick NJ
Lawrence Marlin - Bridgewater NJ

B05D 302
A61L 2900

427 228

A method of making articles having lubricious polymeric coatings are disclosed. The coatings are comprised of a substantially homogeneous composite of poly(ethylene oxide) and polyisocyanate applied in a single step operation as a mixture in an inert solvent. The coating is believed to form a polymeric complex through an in-situ hydrolysis of the polyisocyanate in the system without substantial crosslinking to form polyurethanes. The polymeric complexes have particular utility in providing medical devices such as catheters with a high degree of abrasion resistance and lubricity when in contact with bodily fluids.

4430235, Feb 7, 1984

Jul 17, 1981

6/284389

Nan S. Chu - Hartsdale NY
Lawrence Marlin - Yorktown Heights NY

Union Carbide Corporation - Danbury CT

C07F 708
C07F 710
C10M 322
C10M 344

252 496

Polymeric antioxidants comprising polyorganosiloxane backbones having joined thereto, by non-hydrolyzable linkages, aromatic antioxidant moieties.

5509899, Apr 23, 1996

Sep 22, 1994

8/310730

You-Ling Fan - East Brunswick NJ
Lawrence Marlin - Bridgewater NJ
Ronald A. Sahatjian - Lexington MA
Steven A. Schultz - Northboro MA

Boston Scientific Corp. - Natick MA

A61M 2900

604 96

A medical balloon and catheter in which the balloon (14) is wrapped and folded upon itself tortuously and tightly so outer surfaces (12) contact each other for insertion into the body and in which the balloon is free of bridging and adhesion between abutting surfaces. The balloon has a base of a continuous polymeric surface (10) expandable from a folded, wrapped configuration with surfaces touching each other into a balloon when inflated. A lubricious, biocompatible, hydrogel coating (11) is disposed on the polymeric surface and a thin, lubricious, blood-compatible coating (12) is disposed upon the hydrogel coating and adheres to it to prevent abutting surfaces of the folded polymeric surfaces from adhering to each other during inflation and to prevent delamination of the hydrogel coating and/or rupture of the balloon. Preferably the blood-compatible coating (12) is polyethylene glycol, methoxy polyethylene glycol or mixtures thereof having a molecular weight between about 100 and 20,000 grams per gram mole.

5295978, Mar 22, 1994

Dec 28, 1990

7/635914

You-Ling Fan - East Brunswick NJ
Lawrence Marlin - Bridgewater NJ

Union Carbide Chemicals & Plastics Technology Corporation - Danbury CT

A61M 2500

604265

Biocompatible polymeric complexes having utility in many fields including medical applications, as well as personal and health care, are provided and can be affixed to a variety of substrate materials which themselves may or may not also be biocompatible. The complexes of this invention are comprised of a carboxylic acid polymer with either a poly(lower-alkylene oxide) or a poly(N-vinyl lactam). Moreover, a complex of an antimicrobial agent such as iodine can be formed with the complex to provide antimicrobial activity. The complexes are also useful for forming biocompatible coatings on medical devices, some of which can render the surface lubricious when exposed to aqueous or body fluids.

5948401, Sep 7, 1999

Dec 23, 1996

8/772651

David Hagop Donabedian - Somerset NJ
Donna Jean Eng - Hartsdale NY
Lawrence Marlin - Bridgewater NJ

Union Carbide Chemicals & Plastics Technology Corporation - Danbury CT

A61K 4732
A61K 4734
A61K 4736

424 7804

The present invention relates to delivery systems comprising a cationic polymer, optionally in conjunction with an anionic polymer, to deliver cationic therapeutic agents and their application to a mucosal surface. In particular, these delivery systems are well suited for the treatment of intraocular pressure and glaucoma by way of a sustained delivery system.

5731087, Mar 24, 1998

Jun 7, 1995

8/478990

You Ling Fan - East Brunswick NJ
Lawrence Marlin - Bridgewater NJ
Lisa M. Bouldin - Cranford NJ
Isabel Maria Marino - Somerset NJ

Union Carbide Chemicals & Plastics Technology Corporation - Danbury CT

A61L 2900
A61L 3100
C08J 704

428412

Lubricious coatings comprising a binder polymer having a vinyl moiety and a carboxylic acid moiety and a hydrophilic polymer are disclosed. The coatings can be applied to a variety of substrates such as, for example, catheters, stents, dilatation balloons, guide wires, endotracheal tubes, instruments, implants and other biomedical devices and can provide exceptional lubricity and abrasion resistance. Processes for applying the lubricious coatings in either one or two coating steps are also disclosed.

5645827, Jul 8, 1997

Jan 19, 1995

8/375498

Lawrence Marlin - Bridgewater NJ
Ronald Kenichi Yamamoto - San Francisco CA

Union Carbide Chemicals & Plastics Technology Corporation - Danbury CT

A61K 3174
A61K 4736

424 7804

Compositions comprising cationic polysaccharide polymers and anionic therapeutic agents which can have enhanced substantivity to mucosal surfaces are disclosed. These compositions are well suited, for example, for the delivery of anionic ophthalmic pharmaceuticals because they can provide clear solution in addition to substantivity.

5620738, Apr 15, 1997

Jun 7, 1995

8/486413

You L. Fan - East Brunswick NJ
Lawrence Marlin - Bridgewater NJ
Lisa M. Bouldin - Cranford NJ
Isabel M. Marino - Somerset NJ

Union Carbide Chemicals & Plastics Technology Corporation - Danbury CT

B05D 136
B05D 138
B05D 702
B05D 508

427 23

Lubricious coatings comprising a binder polymer which is a copolymer of vinyl chloride, vinyl acetate and a carboxylic acid moiety and a hydrophilic polymer are disclosed. The coatings can be applied to a variety of substrates such as, for example, catheters, stents, dilatation balloons, guide wires, endotracheal tubes, instruments, implants and other biomedical devices and can provide exceptional lubricity and abrasion resistance. Processes for applying the lubricious coatings in either one or two coating steps are also disclosed.