BackgroundCheck.run
Search For

Robert T Babine, 5356 Middle Rd, Kensington, NH 03833

Known as:
Kathleen L Babine Bob T Babine Rob T Babine Robert T Babin Robt Babine
Related to:
Keith Babine 67

Robert Babine Phones & Addresses

56 Middle Rd, Brentwood, NH 03833    603-7757745   

23 Tremont St, Exeter, NH 03833    603-7757745   

Portsmouth, NH   

Amesbury, MA   

Hampton, NH   

Salisbury, MA   

Get Report
Control this profile

Mentions for Robert T Babine

Publications & IP owners

Us Patents

Carm1 Inhibitors And Uses Thereof

US Patent:
2021015, May 27, 2021
Filed:
Mar 18, 2020
Appl. No.:
16/822478
Inventors:
- Cambridge MA, US
Oscar Miguel Moradei - Burlington MA, US
Gideon Shapiro - Gainesville FL, US
Lei Jin - Wellesley MA, US
Robert E. Babine - Carlsbad CA, US
International Classification:
C07D 487/10
C07D 403/12
C07D 405/14
C07D 413/14
C07D 401/04
C07D 403/04
C07D 405/04
C07D 405/12
C07D 239/42
C07D 409/14
C07D 413/12
C07D 417/14
C07D 471/04
C07D 471/10
C07D 487/08
C07D 493/04
C07D 493/10
C07D 495/04
C07D 498/04
C07D 498/10
C07D 413/04
C07D 487/04
Abstract:
Provided herein are compounds of Formula (I):and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein X, R, R, R, R, R, R, are as defined herein, and Ring HET is a 6-membered monocyclic heteroaryl ring system of Formula:wherein L, R, G, G, G, and Gare as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.

Carm1 Inhibitors And Uses Thereof

US Patent:
2018028, Oct 4, 2018
Filed:
Dec 8, 2017
Appl. No.:
15/835758
Inventors:
- Cambridge MA, US
Oscar Miguel Moradei - Burlington MA, US
Gideon Shapiro - Gainesville FL, US
Lei Jin - Wellesley MA, US
Robert E. Babine - Carlsbad CA, US
International Classification:
C07D 487/10
C07D 403/12
C07D 487/04
C07D 498/10
C07D 498/04
C07D 495/04
C07D 493/10
C07D 493/04
C07D 487/08
C07D 471/10
C07D 471/04
C07D 417/14
C07D 413/12
C07D 409/14
C07D 239/42
C07D 405/12
C07D 405/04
C07D 403/04
C07D 401/04
C07D 413/14
C07D 405/14
C07D 413/04
Abstract:
Provided herein are compounds of Formula (I):and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X, R, R, R, R, R, R, are as defined herein, and Ring HET is a 6-membered monocyclic heteroaryl ring system of Formula:wherein L, R, G, G, G, and Gare as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.

Carm1 Inhibitors And Uses Thereof

US Patent:
2017032, Nov 9, 2017
Filed:
Jul 13, 2017
Appl. No.:
15/648701
Inventors:
- Cambridge MA, US
Oscar Miguel MORADEI - Burlington MA, US
Gideon SHAPIRO - Gainesville FL, US
Lei JIN - Wellesley MA, US
Robert E. BABINE - Carlsbad CA, US
International Classification:
C07D 487/10
C07D 239/42
C07D 495/04
C07D 493/10
C07D 493/04
C07D 487/08
C07D 487/04
C07D 471/10
C07D 471/04
C07D 417/14
C07D 413/14
C07D 413/12
C07D 413/04
C07D 409/14
C07D 405/14
C07D 405/12
C07D 405/04
C07D 403/12
C07D 403/04
C07D 401/04
C07D 498/04
C07D 498/10
Abstract:
Provided herein are compounds of Formula (I):and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X, R, R, R, R, R, R, are as defined herein, and Ring HET is a 6-membered monocyclic heteroaryl ring system of Formula:wherein L, R, G, G, G, and Gare as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.

Carm1 Inhibitors And Uses Thereof

US Patent:
2017030, Oct 26, 2017
Filed:
Sep 17, 2015
Appl. No.:
15/511503
Inventors:
- Cambridge MA, US
Oscar Miguel Moradei - Burlington MA, US
Gideon Shapiro - Gainesville FL, US
Lei JIn - Wellesley MA, US
Robert E. Babine - Carlsbad CA, US
Assignee:
Epizyme, Inc. - Cambridge MA
International Classification:
C07D 487/10
C07D 471/04
C07D 471/10
C07D 487/04
Abstract:
Provided herein are compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein R1, R2a, R2b, R3 and Ring B are as defined herein, and Ring A is a group of Formula (A-i), (A-ii), or (A-iii): wherein R, R, R, R, and R are as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.

Salts, Co-Crystals, Amorphous Forms, And Crystalline Forms Of A Co-Activator-Associated Arginine Methyltransferase 1 (Carm1) Inhibitor

US Patent:
2017029, Oct 19, 2017
Filed:
Sep 17, 2015
Appl. No.:
15/511520
Inventors:
- Cambridge MA, US
Oscar Miguel Moradei - Burlington MA, US
Gideon Shapiro - Gainesville FL, US
Richard Chesworth - Concord MA, US
Lei Jin - Wellesley MA, US
Robert E. Babine - Carlsbad CA, US
Assignee:
Epizyme, Inc - Cambridge MA
International Classification:
C07D 487/10
C07C 65/05
Abstract:
Provided herein are solid forms (e.g., salts, co-crystals, amorphous forms, and crystalline forms) of methyl (R)-2-(2-(2-chloro-5-(2-hydroxy-3-(methylamino)propoxy)phenyl)-6-(3,5-dimethylisoxazol-4-yl)-5-methylpyrimidin-4-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate (compound 109-3). Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve the solid forms for inhibiting the activity of co-activator-associated arginine methyltransferase 1 (CARM1) and for treating CARM1-mediated disorders (e.g., proliferative disorders and metabolic disorders).

Carm1 Inhibitors And Uses Thereof

US Patent:
2017028, Oct 5, 2017
Filed:
Sep 17, 2015
Appl. No.:
15/511507
Inventors:
- Cambridge MA, US
Oscar Miguel Moradei - Burlington MA, US
Gideon Shapiro - Gainesville FL, US
Kenneth W. Duncan - Westwood MA, US
Lorna Helen Mitchell - Cambridge MA, US
Lei Jin - Wellesley MA, US
Robert E. Babine - Carlsbad CA, US
Assignee:
Epizyme, Inc. - Cambridge MA
International Classification:
C07D 519/00
C07D 487/04
C07D 405/12
C07D 471/04
Abstract:
Provided herein are compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X, R, R, R, R, R, are as defined herein, and Ring HET is an optionally substituted 6,5-bicyclic heteroaryl ring system comprising 2 to 5 nitrogen atoms, inclusive, wherein the point of attachment is provided on the 6-membered ring of the 6,5-bicyclic heteroaryl ring system, and wherein the 6-membered ring is further substituted with a group of formula -L-R, wherein Land Rare as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.

Carm1 Inhibitors And Uses Thereof

US Patent:
2017005, Mar 2, 2017
Filed:
Apr 7, 2016
Appl. No.:
15/092903
Inventors:
- Cambridge MA, US
Oscar Miguel Moradei - Burlington MA, US
Gideon Shapiro - Gainesville FL, US
Lei Jin - Wellesley MA, US
Robert E. Babine - Carlsbad CA, US
Assignee:
Epizyme, Inc. - Cambridge MA
International Classification:
A61K 31/5377
A61K 31/506
Abstract:
Provided herein are compounds of Formula (I):and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X, R, R, R, R, R, are as defined herein, and Ring HET is a 6-membered monocyclic heteroaryl ring system of formula:wherein L, R, G, G, G, and Gare as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.

1-Phenoxy-3-(Alkylamino)-Propan-2-Ol Derivatives As Carm1 Inhibitors And Uses Thereof

US Patent:
2016005, Feb 25, 2016
Filed:
Mar 14, 2014
Appl. No.:
14/775197
Inventors:
- Cambridge MA, US
Oscar Miguel Moradei - Burlington MA, US
Gideon Shapiro - Gainesville FL, US
Kenneth W. Duncan - Westwood MA, US
Loma Helen Mitchell - Cambridge MA, US
Lei JIn - Wellesley MA, US
Robert E. Babine - Carlsbad CA, US
Assignee:
Epizyme. Inc. - Cambridge MA
International Classification:
C07D 471/04
C07D 487/04
C07D 498/08
Abstract:
Provided herein are compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X, R, R, R, R, R, are as defined herein, and Ring HET is an optionally substituted 6,5-bicyclic heteroaryl ring system comprising 2 to 5 nitrogen atoms, inclusive, wherein the point of attachment is provided on the 6-membered ring of the 6,5-bicyclic heteroaryl ring system, and wherein the 6-membered ring is further substituted with a group of formula -L-R, wherein Land Rare as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.

Isbn (Books And Publications)

Protein Crystallography In Drug Discovery

Author:
Robert E. Babine
ISBN #:
3527306781

Possible Relatives

David H Babine  Daniel F Babine  Jessica D Babine  John E Babine  Katherine Babine  Ann T Babine  Barbara M Babine  Robert P Johnson  Robert Stan  Robert D Stanard 

NOTICE: You may not use BackgroundCheck or the information it provides to make decisions about employment, credit, housing or any other purpose that would require Fair Credit Reporting Act (FCRA) compliance. BackgroundCheck is not a Consumer Reporting Agency (CRA) as defined by the FCRA and does not provide consumer reports.