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Robert T Babine, 5456 Middle Rd, Brentwood, NH 03833

Known as:
Kathleen L Babine Bob T Babine Rob T Babine Robert T Babin Robt Babine
Related to:
Keith Babine 68

Robert Babine Phones & Addresses

56 Middle Rd, Brentwood, NH 03833    603-7757745   

23 Tremont St, Exeter, NH 03833    603-7757745   

Portsmouth, NH   

Amesbury, MA   

Hampton, NH   

Salisbury, MA   

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Mentions for Robert T Babine

Publications & IP owners

Us Patents

Carm1 Inhibitors And Uses Thereof

US Patent:
2021015, May 27, 2021
Filed:
Mar 18, 2020
Appl. No.:
16/822478
Inventors:
- Cambridge MA, US
Oscar Miguel Moradei - Burlington MA, US
Gideon Shapiro - Gainesville FL, US
Lei Jin - Wellesley MA, US
Robert E. Babine - Carlsbad CA, US
International Classification:
C07D 487/10
C07D 403/12
C07D 405/14
C07D 413/14
C07D 401/04
C07D 403/04
C07D 405/04
C07D 405/12
C07D 239/42
C07D 409/14
C07D 413/12
C07D 417/14
C07D 471/04
C07D 471/10
C07D 487/08
C07D 493/04
C07D 493/10
C07D 495/04
C07D 498/04
C07D 498/10
C07D 413/04
C07D 487/04
Abstract:
Provided herein are compounds of Formula (I):and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein X, R, R, R, R, R, R, are as defined herein, and Ring HET is a 6-membered monocyclic heteroaryl ring system of Formula:wherein L, R, G, G, G, and Gare as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.

Carm1 Inhibitors And Uses Thereof

US Patent:
2018028, Oct 4, 2018
Filed:
Dec 8, 2017
Appl. No.:
15/835758
Inventors:
- Cambridge MA, US
Oscar Miguel Moradei - Burlington MA, US
Gideon Shapiro - Gainesville FL, US
Lei Jin - Wellesley MA, US
Robert E. Babine - Carlsbad CA, US
International Classification:
C07D 487/10
C07D 403/12
C07D 487/04
C07D 498/10
C07D 498/04
C07D 495/04
C07D 493/10
C07D 493/04
C07D 487/08
C07D 471/10
C07D 471/04
C07D 417/14
C07D 413/12
C07D 409/14
C07D 239/42
C07D 405/12
C07D 405/04
C07D 403/04
C07D 401/04
C07D 413/14
C07D 405/14
C07D 413/04
Abstract:
Provided herein are compounds of Formula (I):and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X, R, R, R, R, R, R, are as defined herein, and Ring HET is a 6-membered monocyclic heteroaryl ring system of Formula:wherein L, R, G, G, G, and Gare as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.

Carm1 Inhibitors And Uses Thereof

US Patent:
2017032, Nov 9, 2017
Filed:
Jul 13, 2017
Appl. No.:
15/648701
Inventors:
- Cambridge MA, US
Oscar Miguel MORADEI - Burlington MA, US
Gideon SHAPIRO - Gainesville FL, US
Lei JIN - Wellesley MA, US
Robert E. BABINE - Carlsbad CA, US
International Classification:
C07D 487/10
C07D 239/42
C07D 495/04
C07D 493/10
C07D 493/04
C07D 487/08
C07D 487/04
C07D 471/10
C07D 471/04
C07D 417/14
C07D 413/14
C07D 413/12
C07D 413/04
C07D 409/14
C07D 405/14
C07D 405/12
C07D 405/04
C07D 403/12
C07D 403/04
C07D 401/04
C07D 498/04
C07D 498/10
Abstract:
Provided herein are compounds of Formula (I):and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X, R, R, R, R, R, R, are as defined herein, and Ring HET is a 6-membered monocyclic heteroaryl ring system of Formula:wherein L, R, G, G, G, and Gare as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.

Carm1 Inhibitors And Uses Thereof

US Patent:
2017030, Oct 26, 2017
Filed:
Sep 17, 2015
Appl. No.:
15/511503
Inventors:
- Cambridge MA, US
Oscar Miguel Moradei - Burlington MA, US
Gideon Shapiro - Gainesville FL, US
Lei JIn - Wellesley MA, US
Robert E. Babine - Carlsbad CA, US
Assignee:
Epizyme, Inc. - Cambridge MA
International Classification:
C07D 487/10
C07D 471/04
C07D 471/10
C07D 487/04
Abstract:
Provided herein are compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein R1, R2a, R2b, R3 and Ring B are as defined herein, and Ring A is a group of Formula (A-i), (A-ii), or (A-iii): wherein R, R, R, R, and R are as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.

Salts, Co-Crystals, Amorphous Forms, And Crystalline Forms Of A Co-Activator-Associated Arginine Methyltransferase 1 (Carm1) Inhibitor

US Patent:
2017029, Oct 19, 2017
Filed:
Sep 17, 2015
Appl. No.:
15/511520
Inventors:
- Cambridge MA, US
Oscar Miguel Moradei - Burlington MA, US
Gideon Shapiro - Gainesville FL, US
Richard Chesworth - Concord MA, US
Lei Jin - Wellesley MA, US
Robert E. Babine - Carlsbad CA, US
Assignee:
Epizyme, Inc - Cambridge MA
International Classification:
C07D 487/10
C07C 65/05
Abstract:
Provided herein are solid forms (e.g., salts, co-crystals, amorphous forms, and crystalline forms) of methyl (R)-2-(2-(2-chloro-5-(2-hydroxy-3-(methylamino)propoxy)phenyl)-6-(3,5-dimethylisoxazol-4-yl)-5-methylpyrimidin-4-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate (compound 109-3). Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve the solid forms for inhibiting the activity of co-activator-associated arginine methyltransferase 1 (CARM1) and for treating CARM1-mediated disorders (e.g., proliferative disorders and metabolic disorders).

Carm1 Inhibitors And Uses Thereof

US Patent:
2017028, Oct 5, 2017
Filed:
Sep 17, 2015
Appl. No.:
15/511507
Inventors:
- Cambridge MA, US
Oscar Miguel Moradei - Burlington MA, US
Gideon Shapiro - Gainesville FL, US
Kenneth W. Duncan - Westwood MA, US
Lorna Helen Mitchell - Cambridge MA, US
Lei Jin - Wellesley MA, US
Robert E. Babine - Carlsbad CA, US
Assignee:
Epizyme, Inc. - Cambridge MA
International Classification:
C07D 519/00
C07D 487/04
C07D 405/12
C07D 471/04
Abstract:
Provided herein are compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X, R, R, R, R, R, are as defined herein, and Ring HET is an optionally substituted 6,5-bicyclic heteroaryl ring system comprising 2 to 5 nitrogen atoms, inclusive, wherein the point of attachment is provided on the 6-membered ring of the 6,5-bicyclic heteroaryl ring system, and wherein the 6-membered ring is further substituted with a group of formula -L-R, wherein Land Rare as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.

Carm1 Inhibitors And Uses Thereof

US Patent:
2017005, Mar 2, 2017
Filed:
Apr 7, 2016
Appl. No.:
15/092903
Inventors:
- Cambridge MA, US
Oscar Miguel Moradei - Burlington MA, US
Gideon Shapiro - Gainesville FL, US
Lei Jin - Wellesley MA, US
Robert E. Babine - Carlsbad CA, US
Assignee:
Epizyme, Inc. - Cambridge MA
International Classification:
A61K 31/5377
A61K 31/506
Abstract:
Provided herein are compounds of Formula (I):and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X, R, R, R, R, R, are as defined herein, and Ring HET is a 6-membered monocyclic heteroaryl ring system of formula:wherein L, R, G, G, G, and Gare as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.

1-Phenoxy-3-(Alkylamino)-Propan-2-Ol Derivatives As Carm1 Inhibitors And Uses Thereof

US Patent:
2016005, Feb 25, 2016
Filed:
Mar 14, 2014
Appl. No.:
14/775197
Inventors:
- Cambridge MA, US
Oscar Miguel Moradei - Burlington MA, US
Gideon Shapiro - Gainesville FL, US
Kenneth W. Duncan - Westwood MA, US
Loma Helen Mitchell - Cambridge MA, US
Lei JIn - Wellesley MA, US
Robert E. Babine - Carlsbad CA, US
Assignee:
Epizyme. Inc. - Cambridge MA
International Classification:
C07D 471/04
C07D 487/04
C07D 498/08
Abstract:
Provided herein are compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X, R, R, R, R, R, are as defined herein, and Ring HET is an optionally substituted 6,5-bicyclic heteroaryl ring system comprising 2 to 5 nitrogen atoms, inclusive, wherein the point of attachment is provided on the 6-membered ring of the 6,5-bicyclic heteroaryl ring system, and wherein the 6-membered ring is further substituted with a group of formula -L-R, wherein Land Rare as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.

Isbn (Books And Publications)

Protein Crystallography In Drug Discovery

Author:
Robert E. Babine
ISBN #:
3527306781

Possible Relatives

David H Babine  Daniel F Babine  Jessica D Babine  John E Babine  Katherine Babine  Ann T Babine  Barbara M Babine  Robert P Johnson  Robert Stan  Robert D Stanard 

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