Robert B Curl, 52109 Concord Ave, Richwood, TX 77531

6995841, Feb 7, 2006

Aug 28, 2001

09/941165

Graham B. I. Scott - Houston TX, US
Carter Kittrell - Houston TX, US
Robert F. Curl - Houston TX, US
Michael L. Metzker - Houston TX, US

Rice University - Houston TX
Baylor College of Medicine - Houston TX

G01J 3/30
G01N 21/25
F21V 9/16

356318, 356417, 2504591

The present invention provides a technology called Pulse-Multiline Excitation or PME. This technology provides a novel approach to fluorescence detection with application for high-throughput identification of informative SNPs, which could lead to more accurate diagnosis of inherited disease, better prognosis of risk susceptibilities, or identification of sporadic mutations. The PME technology has two main advantages that significantly increase fluorescence sensitivity: (1) optimal excitation of all fluorophores in the genomic assay and (2) “color-blind” detection, which collects considerably more light than standard wavelength resolved detection. Successful implementation of the PME technology will have broad application for routine usage in clinical diagnostics, forensics, and general sequencing methodologies and will have the capability, flexibility, and portability of targeted sequence variation assays for a large majority of the population.

7511811, Mar 31, 2009

Oct 12, 2005

11/248910

Graham B. I. Scott - Houston TX, US
Carter Kittrell - Houston TX, US
Robert F. Curl - Houston TX, US
Michael L. Metzker - Houston TX, US

Baylor College of Medicine and Rice University - Houston TX

G01J 3/30

356317

The present invention provides a technology called Pulse-Multiline Excitation or PME. This technology provides a novel approach to fluorescence detection with application for high-throughput identification of informative SNPs, which could lead to more accurate diagnosis of inherited disease, better prognosis of risk susceptibilities, or identification of sporadic mutations. The PME technology has two main advantages that significantly increase fluorescence sensitivity: (1) optimal excitation of all fluorophores in the genomic assay and (2) “color-blind” detection, which collects considerably more light than standard wavelength resolved detection. This technology differs significantly from the current state-of-the-art DNA sequencing instrumentation, which features single source excitation and color dispersion for DNA sequence identification. Successful implementation of the PME technology will have broad application for routine usage in clinical diagnostics, forensics, and general sequencing methodologies and will have the capability, flexibility, and portability of targeted sequence variation assays for a large majority of the population.

7733924, Jun 8, 2010

Aug 15, 2005

11/203785

Gerard Wysocki - Houston TX, US
Frank K. Tittel - Houston TX, US
Robert F. Curl - Houston TX, US

William Marsh Rice University - Houston TX

H01S 3/10

372 20

A widely tunable, mode-hop-free semiconductor laser operating in the mid-IR comprises a QCL laser chip having an effective QCL cavity length, a diffraction grating defining a grating angle and an external cavity length with respect to said chip, and means for controlling the QCL cavity length, the external cavity length, and the grating angle. The laser of claim wherein said chip may be tuned over a range of frequencies even in the absence of an anti-reflective coating. The diffraction grating is controllably pivotable and translatable relative to said chip and the effective QCL cavity length can be adjusted by varying the injection current to the chip. The laser can be used for high resolution spectroscopic applications and multi species trace-gas detection. Mode-hopping is avoided by controlling the effective QCL cavity length, the external cavity length, and the grating angle so as to replicate a virtual pivot point.

8009293, Aug 30, 2011

Nov 9, 2006

12/089692

Anatoliy A. Kosterev - Pearland TX, US
Robert F. Curl - Houston TX, US

William Marsh Rice University - Houston TX

G01N 21/00

356432, 356323, 356128

Novel methods and laser spectroscopic systems for accurately measuring the concentration of compounds are disclosed herein. The disclosed methods utilize a modulation cancellation technique resulting in a significantly increase in the sensitivity and accuracy of laser spectroscopic measurements. In general, the methods and systems utilize modulation phase-shifting and amplitude attenuation to cancel the signals detected from at least two modulated light beams. Thus, any signal detected will be directly proportional to the concentration measurement.

8089628, Jan 3, 2012

Feb 18, 2009

12/388358

Graham B. I. Scott - Houston TX, US
Carter Kittrell - Houston TX, US
Robert F. Curl - Houston TX, US
Michael L. Metzker - Houston TX, US

Baylor College of Medicine - Houston TX
Rice University - Houston TX

G01N 21/25

356417

The present invention provides a technology called Pulse-Multiline Excitation or PME. This technology provides a novel approach to fluorescence detection with application for high-throughput identification of informative SNPs, which could lead to more accurate diagnosis of inherited disease, better prognosis of risk susceptibilities, or identification of sporadic mutations. The PME technology has two main advantages that significantly increase fluorescence sensitivity: (1) optimal excitation of all fluorophores in the genomic assay and (2) “color-blind” detection, which collects considerably more light than standard wavelength resolved detection. Successful implementation of the PME technology will have broad application for routine usage in clinical diagnostics, forensics, and general sequencing methodologies and will have the capability, flexibility, and portability of targeted sequence variation assays for a large majority of the population.

2012021, Aug 30, 2012

Jan 3, 2012

13/342471

Graham B. I. Scott - Houston TX, US
Carter Kittrell - Houston TX, US
Robert F. Curl - Houston TX, US
Michael Metzker - Houston TX, US

H01S 3/00
G02B 5/04

372 3802, 359831

The present invention provides a technology called Pulse-Multiline Excitation or PME. This technology provides a novel approach to fluorescence detection with application for high-throughput identification of informative SNPs, which could lead to more accurate diagnosis of inherited disease, better prognosis of risk susceptibilities, or identification of sporadic mutations. The PME technology has two main advantages that significantly increase fluorescence sensitivity: (1) optimal excitation of all fluorophores in the genomic assay and (2) “color-blind” detection, which collects considerably more light than standard wavelength resolved detection. Successful implementation of the PME technology will have broad application for routine usage in clinical diagnostics, forensics, and general sequencing methodologies and will have the capability, flexibility, and portability of targeted sequence variation assays for a large majority of the population.