Robert E Hillman225 Franklin St, Boston, MA 02110

2005028, Dec 22, 2005

Jun 16, 2004

10/869666

Robert Hillman - Weston MA, US
Steven Zeitels - Boston MA, US
James Kobler - Andover MA, US
James Heaton - Mansfield MA, US
Ehab Goldstein - Somerville MA, US

A61F002/20

381070000, 623009000

A voice prosthesis includes a voice actuator for generating a signal to be modulated into speech and a neural interface for receiving a signal indicative of neural activity. A signal processing system in communication with both the neural interface and the voice actuator is configured to provide the voice actuator with a control signal representative of the neural activity.

2010005, Mar 4, 2010

Sep 3, 2009

12/553800

Steven M. Zeitels - Newton MA, US
Robert Edward Hillman - Weston MA, US
Sandeep Sidram Karajanagi - Malden MA, US
Robert S. Langer - Newton MA, US

A61K 9/00
C07C 43/11
C07C 31/18
C07K 14/00
C08B 37/00
C08B 37/02
C08B 37/04
C07K 14/78
A61P 19/04
C08B 15/06
A61K 35/00
A61K 35/12
A61K 38/02
A61K 38/16
A61K 31/7052

424484, 568679, 568852, 530402, 5361231, 536 551, 536 51, 530354, 530353, 530356, 536 30, 424 931, 424 937, 514 2, 514 12, 514 44 R

The present invention provides hydrogels and compositions thereof for vocal cord repair or augmentation, as well as other soft tissue repair or augmentation (e.g., bladder neck augmentation, dermal fillers, breast implants, intervertebral disks, muscle-mass). The hydrogels or compositions thereof are injected into the superficial lamina propria or phonatory epithelium to restore the phonatory mucosa of the vocal cords, thereby restoring a patient's voice. In particular, it has been discovered that hydrogels with an elastic shear modulus of approximately 25 Pa are useful in restoring the pliability of the phonatory mucosa. The invention also provides methods of preparing and using the inventive hydrogels.

2013004, Feb 14, 2013

Mar 4, 2011

13/579347

Steven M. Zeitels - Newton MA, US
Robert E. Hillman - Weston MA, US
Sandeep Sidram Karajanagi - Malden MA, US
Robert S. Langer - Newton MA, US

MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
THE GENERAL HOSPITAL CORPORATION - Boston MA

A61F 2/00

623 1411

The disclosure relates to methods and systems for making customized treatments to a subject's vocal tissues to provide a desired level of vocal function.

2022040, Dec 22, 2022

Jun 21, 2021

17/352550

- Bedford MA, US
Robert S. Hillman - Bedford MA, US

A61B 5/1459
G01N 21/49

An example system includes a chamber to hold a mixture that includes a whole blood sample from a patient, a light source to illuminate the mixture in the chamber, a detector to detect light from the light source transmitted through the mixture in the chamber, and one or more processing devices to determine, based on the light detected by the detector, a platelet aggregation value of the whole blood sample that is substantially independent of a hematocrit of the whole blood sample.

2017001, Jan 19, 2017

Sep 27, 2016

15/278007

- Boston MA, US
- West Layfayette IN, US
Daryush D Mehta - Boston MA, US
George R. Wodicka - West Lafayette IN, US
Robert E. Hillman - Weston MA, US

A61B 5/00
G10L 25/75
A61B 5/087
A61B 5/107
A61B 5/11

A system and method to assess vocal function of a subject. The system includes an accelerometer configured to acquire surface acceleration data associated with vocal functionality of the subject and a computer system configured to analyze the surface acceleration data and to estimate glottal airflow waveforms produced by the subject based on the surface acceleration data. The computer system performs the analysis and estimation by applying an inverse filter to the surface acceleration data based on a calibrated transmission line model and generates an indication of vocal functionality of the subject based on the estimated glottal airflow waveforms.