Robert J Kaminski, 382595 Norfolk Rd, Cleveland, OH 44106

7632659, Dec 15, 2009

Nov 23, 2004

10/994463

Edwin V. Oaks - Gambrills MD, US
Robert W. Kaminski - Germantown MD, US

The United States of America as represented by the Secretary of the Army - Washington DC

C07H 21/04
C12P 21/06

435 691, 536 231

The in vivo and in vitro use of Invaplex to transport materials, including functional proteins and biologically active nucleic acids, across eukaryotic cell membranes. The eukaryotic cells include a variety of cell types, e. g. insect, reptile, fish, mammal and tumor cells. The suitable materials for transport include biochemicals such as reporter molecules, antibiotics, biopharmaceuticals and carbohydrates including polysaccharides, lipopolysaccharides, polynucleotides, such as DNA and RNA, and glycoproteins and proteins including antigens, enzymes, antibodies, receptors and hormones. In addition, Invaplex enhances the immune response to DNA vaccines and also can function by itself as a vaccine against shigellosis.

7780966, Aug 24, 2010

Mar 27, 2007

11/727486

Edwin V. Oaks - Gambrills MD, US
Kevin R. Turbyfill - Odenton MD, US
Robert W. Kaminski - Germantown MD, US

The United States of America as represented by the Secretary of the Army - Washington DC

A61K 39/116

4242031, 4242341, 4242571, 4242581, 4241931

An artificial invasin complex is prepared from purified or recombinantly prepared invasins and gram negative bacteria lipopolysaccharides. Typically, IpaB is mixed with IpaC to form a IpaB:IpaC complex. This invasin protein complex is then mixed with the lipopolysaccharide to form an artificial invasin complex. Additional bioactive molecules can be incorporated into the complex during manufacture. This artificial invasin complex is similar in function to native Invaplex 24 or Invaplex 50. The artificial invasin complex has superior immunogenicity properties relative to the native complex and can be tailor made. Its method of preparation lends itself to scale up. The artificial invasin complex can facilitate transport of biomolecules, therapeutics and antibiotics across cell membranes in a manner similar to native.

8110354, Feb 7, 2012

Sep 21, 2009

12/563794

Edwin V. Oaks - Gambrills MD, US
Robert W. Kaminski - Germantown MD, US

The United States of America as represented by the Secretary of the Army - Washington DC

C12Q 1/68
C12N 5/00

435 61, 435 615, 435 618, 435325

The in vivo and in vitro use of Invaplex to transport materials, including functional proteins and biologically active nucleic acids, across eukaryotic cell membranes. The eukaryotic cells include a variety of cell types, e. g. insect, reptile, fish, mammal and tumor cells. The suitable materials for transport include biochemicals such as reporter molecules, antibiotics, biopharmaceuticals and carbohydrates including polysaccharides, lipopolysaccharides, polynucleotides, such as DNA and RNA, and glycoproteins and proteins including antigens, enzymes, antibodies, receptors and hormones. In addition, Invaplex enhances the immune response to DNA vaccines and also can function by itself as a vaccine against shigellosis.