Robert H Scannevin, 5426 Huckleberry Rd, Hopkinton, MA 01748
Robert Scannevin Phones & Addresses
26 Huckleberry Rd, Hopkinton, MA 01748 508-6252144
5015 Sundance Ct, Doylestown, PA 18901 215-3407964
Elkridge, MD
Smithtown, NY
517 Curtis Dr, Morrisville, PA 19067 215-4281044
3305 Sterling Rd, Morrisville, PA 19067 215-7573281
Yardley, PA
New Hyde Park, NY
Buck, PA
Raritan, NJ
Sayville, NY
517 Curtis Dr, Morrisville, PA 19067
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Position:
Private Household Service Occupations
Education
Degree:
Graduate or professional degree
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Mentions for Robert H Scannevin
Publications & IP owners
Us Patents
Matrix Metalloprotease Inhibitors
US Patent:
2008008, Apr 10, 2008
Filed:
Sep 24, 2007
Appl. No.:
11/859910
Inventors:
Bingbing Wang - Flemington NJ, US
Robert Scannevin - Doylestown PA, US
Kenneth Rhodes - Doylestown PA, US
Bharat Lagu - Hillsborough NJ, US
Lawrence Wilson - Atlanta GA, US
Prabha Karnachi - Hillsborough NJ, US
William Murray - Belle Mead NJ, US
Robert Scannevin - Doylestown PA, US
Kenneth Rhodes - Doylestown PA, US
Bharat Lagu - Hillsborough NJ, US
Lawrence Wilson - Atlanta GA, US
Prabha Karnachi - Hillsborough NJ, US
William Murray - Belle Mead NJ, US
International Classification:
A61K 31/18
A61K 31/351
A61K 31/381
A61K 31/404
A61K 31/4166
A61K 31/4409
A61K 31/4412
A61K 31/45
A61K 31/472
A61K 31/495
A61K 31/5375
A61K 31/54
A61P 25/00
A61P 35/00
C07C 311/08
C07D 209/08
C07D 209/44
C07D 211/46
C07D 213/56
C07D 213/64
C07D 217/04
C07D 233/02
C07D 241/04
C07D 279/12
C07D 295/15
C07D 333/24
C07D 413/02
C12N 9/99
A61K 31/351
A61K 31/381
A61K 31/404
A61K 31/4166
A61K 31/4409
A61K 31/4412
A61K 31/45
A61K 31/472
A61K 31/495
A61K 31/5375
A61K 31/54
A61P 25/00
A61P 35/00
C07C 311/08
C07D 209/08
C07D 209/44
C07D 211/46
C07D 213/56
C07D 213/64
C07D 217/04
C07D 233/02
C07D 241/04
C07D 279/12
C07D 295/15
C07D 333/24
C07D 413/02
C12N 9/99
US Classification:
514227500, 435184000, 514235500, 514238200, 514255010, 514255020, 514255030, 514307000, 514327000, 514351000, 514357000, 514389000, 514415000, 514416000, 514438000, 514451000, 514605000, 544131000, 544160000, 544383000, 544389000, 544393000, 544058200, 546146000, 546221000, 546300000, 546337000, 548319500, 548482000, 548510000, 549077000, 564099000
Abstract:
The present invention relates to compounds of Formula I, wherein R1, R2, R3, R4, R5, R6, and R7 are defined in the specification. In addition, the present invention relates to methods treating disorders related to matrix metalloproteases. More particularly, the compounds of the present invention are useful for treating stroke.
Heterocyclic Derived Metalloprotease Inhibitors
US Patent:
2008010, May 1, 2008
Filed:
Sep 21, 2007
Appl. No.:
11/858972
Inventors:
Yue-Mei Zhang - Belle Mead NJ, US
Bangping Xiang - Bridgewater NJ, US
Kenneth Rhodes - Hopkinton MA, US
Robert Scannevin - Hopkinton MA, US
Paul Jackson - Whitehouse Station NJ, US
Xiaodong Fan - Center Valley PA, US
Lawrence Wilson - Atlanta GA, US
Prabha Karnachi - Hillsborough NJ, US
Bangping Xiang - Bridgewater NJ, US
Kenneth Rhodes - Hopkinton MA, US
Robert Scannevin - Hopkinton MA, US
Paul Jackson - Whitehouse Station NJ, US
Xiaodong Fan - Center Valley PA, US
Lawrence Wilson - Atlanta GA, US
Prabha Karnachi - Hillsborough NJ, US
International Classification:
A61K 31/55
A61P 35/00
A61P 25/00
C07D 403/02
C07D 223/02
A61P 35/00
A61P 25/00
C07D 403/02
C07D 223/02
US Classification:
514212080, 540604000, 514212030, 540602000, 540598000
Abstract:
This invention provides novel heterocyclic derived matrix metalloprotease inhibitors of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing matrix metalloproteases. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
Heterocyclic Derived Metalloprotease Inhibitors
US Patent:
2010027, Nov 4, 2010
Filed:
Jul 12, 2010
Appl. No.:
12/834283
Inventors:
Yue-Mei ZHANG - Belle Mead NJ, US
Bangping Xiang - Bridgewater NJ, US
Kenneth Rhodes - Hopkinton MA, US
Robert Scannevin - Hopkinton MA, US
Paul Jackson - Whitehouse Station NJ, US
Xiaodong Fan - Center Valley PA, US
Lawrence J. Wilson - Atlanta GA, US
Prabha Karnachi - Hillsborough NJ, US
Bangping Xiang - Bridgewater NJ, US
Kenneth Rhodes - Hopkinton MA, US
Robert Scannevin - Hopkinton MA, US
Paul Jackson - Whitehouse Station NJ, US
Xiaodong Fan - Center Valley PA, US
Lawrence J. Wilson - Atlanta GA, US
Prabha Karnachi - Hillsborough NJ, US
International Classification:
A61K 31/55
A61K 31/635
A61K 31/4412
A61K 31/5377
A61K 31/45
A61K 31/4436
A61K 31/551
A61K 31/541
A61P 9/00
A61P 9/14
A61P 35/00
A61P 29/00
A61P 25/00
A61P 25/28
A61P 25/14
A61P 19/02
A61P 1/04
A61K 31/635
A61K 31/4412
A61K 31/5377
A61K 31/45
A61K 31/4436
A61K 31/551
A61K 31/541
A61P 9/00
A61P 9/14
A61P 35/00
A61P 29/00
A61P 25/00
A61P 25/28
A61P 25/14
A61P 19/02
A61P 1/04
US Classification:
514157, 51421203, 51421208, 514347, 5142372, 514327, 514336, 514218, 5142278
Abstract:
This invention provides novel heterocyclic derived matrix metalloprotease inhibitors of the formula:and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing matrix metalloproteases. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
Methods Of Inhibiting Pro Matrix Metalloproteinase Activation
US Patent:
2012030, Nov 29, 2012
Filed:
May 24, 2012
Appl. No.:
13/479421
Inventors:
Paul Francis JACKSON - New Hope PA, US
Carl Manthey - Chester Springs PA, US
Kenneth Rhodes - Hopkinton MA, US
Robert Scannevin - Hopkinton MA, US
Kristi Anne Leonard - Lansdale PA, US
Joseph Kent Barbay - Flourtown PA, US
Matthew Todd - Ambler PA, US
Barry A. Springer - Wilmington DE, US
Carl Manthey - Chester Springs PA, US
Kenneth Rhodes - Hopkinton MA, US
Robert Scannevin - Hopkinton MA, US
Kristi Anne Leonard - Lansdale PA, US
Joseph Kent Barbay - Flourtown PA, US
Matthew Todd - Ambler PA, US
Barry A. Springer - Wilmington DE, US
International Classification:
C12N 9/99
A61K 31/4439
A61K 31/497
A61K 31/437
A61K 31/519
A61K 31/444
A61K 31/4985
A61P 35/00
A61P 19/02
A61P 9/00
A61P 1/04
A61P 9/12
A61P 11/00
A61P 1/00
A61P 1/02
A61P 17/02
A61P 25/06
A61K 31/427
A61K 31/4439
A61K 31/497
A61K 31/437
A61K 31/519
A61K 31/444
A61K 31/4985
A61P 35/00
A61P 19/02
A61P 9/00
A61P 1/04
A61P 9/12
A61P 11/00
A61P 1/00
A61P 1/02
A61P 17/02
A61P 25/06
A61K 31/427
US Classification:
514249, 435184, 514371, 514370, 514342, 51425505, 514300, 5142591, 514333
Abstract:
This invention relates to methods for preventing, treating or ameliorating an MMP9 and/or MMP13 mediated syndrome, disorder or disease comprising administering to a subject in need thereof an effective amount of a compound listed in the examples section of this specification, or a form, composition or medicament thereof. Disorders treated and/or prevented include rheumatoid arthritis.
Crystal Structure Of The Pro Form Of A Matrix Metalloproteinase And An Allosteric Processing Inhibitor
US Patent:
2013004, Feb 14, 2013
Filed:
Jun 26, 2012
Appl. No.:
13/533108
Inventors:
Kristi A. Leonard - Lansdale PA, US
Richard Scott Alexander - Newark DE, US
Joseph Kent Barbay - Flourtown PA, US
Roger F. Bone - Bridgewater NJ, US
Ingrid Christa Deckman - Berwyn PA, US
Paul F. Jackson - New Hope PA, US
Lawrence C. Kuo - Gwynedd Valley PA, US
Frank A. Lewandowski - Philadelphia PA, US
Diane M. Maguire - Downingtown PA, US
Cynthia M. Milligan - Rutledge PA, US
Kenneth J. Rhodes - Belmont MA, US
Robert H. Scannevin - Hopkinton MA, US
Celine Schalk-Hihi - Phoenixville PA, US
Barry Springer - Wilmington DE, US
John C. Spurlino - Downingtown PA, US
Matthew J. Todd - Ambler PA, US
Brett Andrew Tongue - Blue Bell PA, US
Aihua Wang - Jamison PA, US
Richard Scott Alexander - Newark DE, US
Joseph Kent Barbay - Flourtown PA, US
Roger F. Bone - Bridgewater NJ, US
Ingrid Christa Deckman - Berwyn PA, US
Paul F. Jackson - New Hope PA, US
Lawrence C. Kuo - Gwynedd Valley PA, US
Frank A. Lewandowski - Philadelphia PA, US
Diane M. Maguire - Downingtown PA, US
Cynthia M. Milligan - Rutledge PA, US
Kenneth J. Rhodes - Belmont MA, US
Robert H. Scannevin - Hopkinton MA, US
Celine Schalk-Hihi - Phoenixville PA, US
Barry Springer - Wilmington DE, US
John C. Spurlino - Downingtown PA, US
Matthew J. Todd - Ambler PA, US
Brett Andrew Tongue - Blue Bell PA, US
Aihua Wang - Jamison PA, US
International Classification:
C12N 9/96
US Classification:
435188
Abstract:
The present invention includes a crystal comprising a complex of the pro form of a matrix metalloprotease (proMMP) and a small-molecule allosteric processing inhibitor that inhibits that activation of the proMMP, methods for identifying small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP, and methods of treatment using small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP. The present invention relates to the crystal structure of a complex of proMMP9 bound to a small-molecule allosteric processing inhibitor that inhibits activation of proMMP9. The invention further relates to the use of the methods and the crystal and related structural information for designing, selecting and/or optimizing small-molecule allosteric processing inhibitors that inhibit activation of proMMP9 and proMMP9 homologues. The present invention also relates to the use of small-molecule allosteric processing inhibitors for the treatment of diseases mediated by inappropriate matrix metalloproteinase (MMP) activity.
Methods Of Treatment Using Allosteric Processing Inhibitors For Matrix Metalloproteinases
US Patent:
2013004, Feb 14, 2013
Filed:
Jun 26, 2012
Appl. No.:
13/533131
Inventors:
Kristi A. Leonard - Lansdale PA, US
Richard Scott Alexander - Newark DE, US
Joseph Kent Barbay - Flourtown PA, US
Roger F. Bone - Bridgewater NJ, US
Carl Crysler - Pottstown PA, US
Ingrid Christa Deckman - Berwyn PA, US
Paul F. Jackson - New Hope PA, US
Lawrence C. Kuo - Gwynedd Valley PA, US
Frank A. Lewandowski - Philadelphia PA, US
Diane M. Maguire - Downingtown PA, US
Carl Manthey - Chester Springs PA, US
Cynthia M. Milligan - Rutledge PA, US
Beverley Moore - North Wales PA, US
Kenneth J. Rhodes - Belmont MA, US
Robert H. Scannevin - Hopkinton MA, US
Celine Schalk-Hihi - Phoenixville PA, US
Barry Springer - Wilmington DE, US
John C. Spurlino - Downingtown PA, US
Matthew J. Todd - Ambler PA, US
Brett Andrew Tongue - Blue Bell PA, US
Aihua Wang - Jamison PA, US
Richard Scott Alexander - Newark DE, US
Joseph Kent Barbay - Flourtown PA, US
Roger F. Bone - Bridgewater NJ, US
Carl Crysler - Pottstown PA, US
Ingrid Christa Deckman - Berwyn PA, US
Paul F. Jackson - New Hope PA, US
Lawrence C. Kuo - Gwynedd Valley PA, US
Frank A. Lewandowski - Philadelphia PA, US
Diane M. Maguire - Downingtown PA, US
Carl Manthey - Chester Springs PA, US
Cynthia M. Milligan - Rutledge PA, US
Beverley Moore - North Wales PA, US
Kenneth J. Rhodes - Belmont MA, US
Robert H. Scannevin - Hopkinton MA, US
Celine Schalk-Hihi - Phoenixville PA, US
Barry Springer - Wilmington DE, US
John C. Spurlino - Downingtown PA, US
Matthew J. Todd - Ambler PA, US
Brett Andrew Tongue - Blue Bell PA, US
Aihua Wang - Jamison PA, US
International Classification:
A61K 31/427
A61P 35/00
A61P 19/02
A61P 9/00
A61P 1/04
A61P 9/12
A61P 11/00
A61P 1/02
A61P 17/02
A61P 1/16
A61P 9/10
A61P 25/00
A61P 11/06
A61P 13/12
A61P 25/06
C12N 9/99
A61K 31/4439
A61P 35/00
A61P 19/02
A61P 9/00
A61P 1/04
A61P 9/12
A61P 11/00
A61P 1/02
A61P 17/02
A61P 1/16
A61P 9/10
A61P 25/00
A61P 11/06
A61P 13/12
A61P 25/06
C12N 9/99
A61K 31/4439
US Classification:
514338, 514371, 514370, 435184
Abstract:
The present invention includes a crystal comprising a complex of the pro form of a matrix metalloprotease (proMMP) and a small-molecule allosteric processing inhibitor that inhibits that activation of the proMMP, methods for identifying small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP, and methods of treatment using small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP. The present invention relates to the crystal structure of a complex of proMMP9 bound to a small-molecule allosteric processing inhibitor that inhibits activation of proMMP9. The invention further relates to the use of the methods and the crystal and related structural information for designing, selecting and/or optimizing small-molecule allosteric processing inhibitors that inhibit activation of proMMP9 and proMMP9 homologues. The present invention also relates to the use of small-molecule allosteric processing inhibitors for the treatment of diseases mediated by inappropriate matrix metalloproteinase (MMP) activity.
Crystal Structure Of The Pro Form Of A Matrix Metalloproteinase And An Allosteric Processing Inhibitor
US Patent:
2013016, Jun 27, 2013
Filed:
Jun 26, 2012
Appl. No.:
13/533201
Inventors:
Kristi A. Leonard - Lansdale PA, US
Richard Scott Alexander - Newark DE, US
Joseph Kent Barbay - Flourtown PA, US
Roger F. Bone - Bridgewater NJ, US
Ingrid Christa Deckman - Berwyn PA, US
Paul F. Jackson - New Hope PA, US
Lawrence C. Kuo - Gwynedd Valley PA, US
Frank A. Lewandowski - Philadelphia PA, US
Diane M. Maguire - Downingtown PA, US
Cynthia M. Milligan - Rutledge PA, US
Kenneth J. Rhodes - Belmont MA, US
Robert H. Scannevin - Hopkinton MA, US
Celine Schalk-Hihi - Phoenixville PA, US
Barry Springer - Wilmington DE, US
John C. Spurlino - Downingtown PA, US
Matthew J. Todd - Ambler PA, US
Brett Andrew Tongue - Blue Bell PA, US
Aihua Wang - Jamison PA, US
Richard Scott Alexander - Newark DE, US
Joseph Kent Barbay - Flourtown PA, US
Roger F. Bone - Bridgewater NJ, US
Ingrid Christa Deckman - Berwyn PA, US
Paul F. Jackson - New Hope PA, US
Lawrence C. Kuo - Gwynedd Valley PA, US
Frank A. Lewandowski - Philadelphia PA, US
Diane M. Maguire - Downingtown PA, US
Cynthia M. Milligan - Rutledge PA, US
Kenneth J. Rhodes - Belmont MA, US
Robert H. Scannevin - Hopkinton MA, US
Celine Schalk-Hihi - Phoenixville PA, US
Barry Springer - Wilmington DE, US
John C. Spurlino - Downingtown PA, US
Matthew J. Todd - Ambler PA, US
Brett Andrew Tongue - Blue Bell PA, US
Aihua Wang - Jamison PA, US
International Classification:
G06F 19/12
US Classification:
703 11
Abstract:
The present invention includes a crystal comprising a complex of the pro form of a matrix metalloprotease (proMMP) and a small-molecule allosteric processing inhibitor that inhibits that activation of the proMMP, methods for identifying small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP, and methods of treatment using small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP. The present invention relates to the crystal structure of a complex of proMMP9 bound to a small-molecule allosteric processing inhibitor that inhibits activation of proMMP9. The invention further relates to the use of the methods and the crystal and related structural information for designing, selecting and/or optimizing small-molecule allosteric processing inhibitors that inhibit activation of proMMP9 and proMMP9 homologues. The present invention also relates to the use of small-molecule allosteric processing inhibitors for the treatment of diseases mediated by inappropriate matrix metalloproteinase (MMP) activity.
Compounds And Uses Thereof
US Patent:
2020026, Aug 20, 2020
Filed:
Oct 24, 2018
Appl. No.:
16/758495
Inventors:
- Cambridge MA, US
Bertrand LE BOURDONNEC - Northborough MA, US
Iwona WRONA - Sharon MA, US
Bhaumik PANDYA - Bedford MA, US
Parcharee TIVITMAHAISOON - Boston MA, US
Kerem OZBOYA - Cambridge MA, US
Benjamin VINCENT - Cambridge MA, US
Daniel TARDIFF - Arlington MA, US
Jeff PIOTROWSKI - Somerville MA, US
Eric SOLIS - Milford MA, US
Robert SCANNEVIN - Hopkinton MA, US
Rebecca ARON - Cambridge MA, US
Kenneth RHODES - Belmont MA, US
Bertrand LE BOURDONNEC - Northborough MA, US
Iwona WRONA - Sharon MA, US
Bhaumik PANDYA - Bedford MA, US
Parcharee TIVITMAHAISOON - Boston MA, US
Kerem OZBOYA - Cambridge MA, US
Benjamin VINCENT - Cambridge MA, US
Daniel TARDIFF - Arlington MA, US
Jeff PIOTROWSKI - Somerville MA, US
Eric SOLIS - Milford MA, US
Robert SCANNEVIN - Hopkinton MA, US
Rebecca ARON - Cambridge MA, US
Kenneth RHODES - Belmont MA, US
International Classification:
C07D 413/14
C07D 413/04
C07D 417/04
C07D 417/14
C07D 471/04
C07D 271/07
C07D 413/10
C07D 487/04
C07D 487/10
C07D 413/04
C07D 417/04
C07D 417/14
C07D 471/04
C07D 271/07
C07D 413/10
C07D 487/04
C07D 487/10
Abstract:
The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.
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