Ronald Earl Heemstra DeceasedSaline, MI
Ronald Heemstra Phones & Addresses
Saline, MI
3954 Grant St, Hudsonville, MI 49426 616-6699394
Mentions for Ronald Earl Heemstra
Publications & IP owners
Us Patents
Preparation Of Substituted Quinazolines
US Patent:
2004015, Aug 12, 2004
Filed:
Feb 4, 2004
Appl. No.:
10/771774
Inventors:
Hubert Barth - Emmendingen, DE
Alexander Bridges - Saline MI, US
Ronald Heemstra - Pinckney MI, US
Nicole Horne - Muskegon MI, US
Robert Hughes - Grand Haven MI, US
Thomas Jacks - Holland MI, US
Dennis McNamara - Ann Arbor MI, US
Simon Schneider - Merzhausen, DE
Klaus Steiner - Emmendingen, DE
Peter Toogood - Ann Arbor MI, US
Roy Winters - Pinckney MI, US
Alexander Bridges - Saline MI, US
Ronald Heemstra - Pinckney MI, US
Nicole Horne - Muskegon MI, US
Robert Hughes - Grand Haven MI, US
Thomas Jacks - Holland MI, US
Dennis McNamara - Ann Arbor MI, US
Simon Schneider - Merzhausen, DE
Klaus Steiner - Emmendingen, DE
Peter Toogood - Ann Arbor MI, US
Roy Winters - Pinckney MI, US
International Classification:
C 07D 4 3/02
US Classification:
544/284000, 544/293000, 544/244000
Abstract:
Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula 1 are disclosed. Such inhibitors, which include N-[4-(3-chloro-4-floro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, are useful for treating cancer, restenosis, atherosclerosis, endometriosis and psoriasis. The disclosed methods employ protecting schemes to minimize undesirable diacryloylamino-quinazoline side products.
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